[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1016/S0378-1119(97)00668-9; PubMed=9524201 [NCBI, ExPASy, EBI, Israel, Japan] Liu C.Z., Yang J.T., Yoon J.W., Walterhouse D., Iannaccone P.; "Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway."; Gene 209:1-11(1998).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=ICR; PubMed=10433919 [NCBI, ExPASy, EBI, Israel, Japan] Sasaki H., Nishizaki Y., Hui C., Nakafuku M., Kondoh H.; "Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling."; Development 126:3915-3924(1999).
[3]	NUCLEOTIDE SEQUENCE [MRNA] OF 272-837. STRAIN=CD-1; TISSUE=Embryo; PubMed=8364225 [NCBI, ExPASy, EBI, Israel, Japan] Waterhouse D., Ahmed M., Slusarski D., Kalamaras J., Boucher D., Holmgren R., Iannaccone P.; "gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development."; Dev. Dyn. 196:91-102(1993).

Comments

FUNCTION: May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36 (By similarity).
TISSUE SPECIFICITY: Uterus, brain, testis and limb.
DEVELOPMENTAL STAGE: Is detected on days 10 through 18 of embryonic development. During gestation it is detected in meckels precartilage mesenchyme, the basis occipitus, rib mesenchymal condensations, primordial vertebral bodies, digital mesenchymal condensations in forefoot and hindfoot plates, the ependymal layer of the spinal cord, and the mesoderm of the gastrointestinal tract. Expression persists throughout gestation in developing bone and cartilage of the extremities, the ribs, and the vertebral bodies as well as the gastrointestinal tract mesoderm.
SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
SIMILARITY: Contains 5 C2H2-type zinc fingers.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF026305; AAC09169.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB025922; BAA85004.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_034426.2; -.

UniGene

Mm.391450

3D structure databases

HSSP

P08151; 2GLI. [HSSP ENTRY / PDB]

ModBase

P47806.

PTM databases

PhosphoSite

P47806; -.

Organism-specific databases

MGI

MGI:95727; Gli1.

Gene expression databases

ArrayExpress

P47806; -.

CleanEx

MM_GLI1; -.

GermOnline

ENSMUSG00000025407; Mus musculus.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from direct assay from MGI).
GO:0005634;	Cellular component: nucleus (inferred from direct assay from MGI).
GO:0003682;	Molecular function: chromatin binding (inferred from direct assay from MGI).
GO:0003677;	Molecular function: DNA binding (inferred from direct assay from MGI).
GO:0008017;	Molecular function: microtubule binding (inferred from direct assay from MGI).
GO:0016563;	Molecular function: transcription activator activity (inferred from direct assay from MGI).
GO:0021696;	Biological process: cerebellar cortex morphogenesis (inferred from genetic interaction from MGI).
GO:0009953;	Biological process: dorsal/ventral pattern formation (inferred from genetic interaction from MGI).
GO:0030324;	Biological process: lung development (inferred from genetic interaction from MGI).
GO:0060032;	Biological process: notochord regression (inferred from genetic interaction from MGI).
GO:0021983;	Biological process: pituitary gland development (inferred from genetic interaction from MGI).
GO:0045944;	Biological process: positive regulation of transcription from RNA polymerase II promoter (inferred from direct assay from MGI).
GO:0009954;	Biological process: proximal/distal pattern formation (inferred from genetic interaction from MGI).
GO:0021938;	Biological process: smoothened signaling pathway in regulation of granule cell precursor cell proliferation (inferred from genetic interaction from MGI).
GO:0007283;	Biological process: spermatogenesis (inferred from direct assay from MGI).
GO:0007418;	Biological process: ventral midline development (inferred from genetic interaction from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR007087; Znf_C2H2.
IPR015880; Znf_C2H2-like.
IPR013087; Znf_C2H2/integrase_DNA-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 4.

Pfam

PF00096; zf-C2H2; 5.
Pfam graphical view of domain structure.

ProDom

PD000003; Znf_C2H2; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00355; ZnF_C2H2; 5.
SMART graphical view of domain structure.

PROSITE

PS00028; ZINC_FINGER_C2H2_1; 4.
PS50157; ZINC_FINGER_C2H2_2; 5.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P47806.

Genome annotation databases

Ensembl

ENSMUSG00000025407; Mus musculus. [Contig view]

GeneID

14632; -.

KEGG

mmu:14632; -.

Phylogenomic databases

HOGENOM

P47806; -.

HOVERGEN

P47806; -.

Other

Gli1; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Developmental protein; Differentiation; DNA-binding; Metal-binding; Nucleus; Transcription; Transcription regulation; Zinc; Zinc-finger.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 1111`	`1111`	`Zinc finger protein GLI1.`	`PRO_0000047198`
`ZN_FING`	`238 263`	`26`	`C2H2-type 1.`
`ZN_FING`	`271 298`	`28`	`C2H2-type 2.`
`ZN_FING`	`304 328`	`25`	`C2H2-type 3.`
`ZN_FING`	`334 359`	`26`	`C2H2-type 4.`
`ZN_FING`	`365 390`	`26`	`C2H2-type 5.`
`COMPBIAS`	`1042 1059`	`18`	`Asp/Glu-rich (acidic).`
`CONFLICT`	`154 154`		`V -> L (in Ref. 1; AAC09169).`
`CONFLICT`	`170 170`		`H -> Y (in Ref. 1; AAC09169).`
`CONFLICT`	`173 173`		`A -> S (in Ref. 1; AAC09169).`
`CONFLICT`	`179 179`		`T -> I (in Ref. 1; AAC09169).`
`CONFLICT`	`194 194`		`P -> R (in Ref. 1; AAC09169).`
`CONFLICT`	`210 210`		`I -> T (in Ref. 1; AAC09169).`
`CONFLICT`	`271 271`		`F -> S (in Ref. 1; AAC09169).`
`CONFLICT`	`475 475`		`Missing (in Ref. 1 and 3).`
`CONFLICT`	`567 569`		`FPP -> LPT (in Ref. 1 and 3).`
`CONFLICT`	`707 707`		`E -> D (in Ref. 1 and 3).`
`CONFLICT`	`777 777`		`Missing (in Ref. 1 and 3).`
`CONFLICT`	`837 837`		`H -> P (in Ref. 3).`
`CONFLICT`	`864 864`		`G -> V (in Ref. 1; AAC09169).`
`CONFLICT`	`919 920`		`GL -> RA (in Ref. 1; AAC09169).`
`CONFLICT`	`936 936`		`S -> Y (in Ref. 1; AAC09169).`
`CONFLICT`	`950 952`		`AAA -> RR (in Ref. 1).`
`CONFLICT`	`967 967`		`G -> R (in Ref. 1; AAC09169).`
`CONFLICT`	`990 990`		`P -> A (in Ref. 1; AAC09169).`
`CONFLICT`	`1029 1029`		`A -> P (in Ref. 1; AAC09169).`
`CONFLICT`	`1062 1063`		`QG -> R (in Ref. 1; AAC09169).`

Sequence information

Length: 1111 AA [This is the length of the unprocessed precursor]

Molecular weight: 118556 Da [This is the MW of the unprocessed precursor]

CRC64: 0DBAB163CAF27289 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MFNPMTPPQV NSYSEPCCLR PLHSQGVPSM GTEGLSGLPF CHQANFMSGS QGYGAARETS 

        70         80         90        100        110        120 
SCTEGSLFPP PPPPRSSVKL TKKRALSISP LSDASLDLQT VIRTSPSSLV AFINSRCTSP 

       130        140        150        160        170        180 
GGSYGHLSIG TMSPSLGFPP QMSHQKGTSP PYGVQPCVPH DSTRGSMMLH PQARGPRATC 

       190        200        210        220        230        240 
QLKSELDMMV GKCPEDPLEG DMSSPNSTGI QDHLLGMLDG REDLEREEKP EPESVYETDC 

       250        260        270        280        290        300 
RWDGCSQEFD SQEQLVHHIN SEHIHGERKE FVCHWGGCSR ELRPFKAQYM LVVHMRRHTG 

       310        320        330        340        350        360 
EKPHKCTFEG CRKSYSRLEN LKTHLRSHTG EKPYMCEQEG CSKAFSNASD RAKHQNRTHS 

       370        380        390        400        410        420 
NEKPYVCKLP GCTKRYTDPS SLRKHVKTVH GPDAHVTKRH RGDGPLPRAQ PLSTVEPKRE 

       430        440        450        460        470        480 
REGGSGREES RLTVPESAMP QQSPGAQSSC SSDHSPAGSA ANTDSGVEMA GNAGGSTEDL 

       490        500        510        520        530        540 
SSLDEGPCVS ATGLSTLRRL ENLRLDQLHQ LRPIGSRGLK LPSLTHAGAP VSRRLGPPVS 

       550        560        570        580        590        600 
LDRRSSSSSS MSSAYTVSRR SSLASPFPPG TPPENGASSL PGLTPAQHYM LRARYASARG 

       610        620        630        640        650        660 
SGTPPTAAHS LDRMGGLSVP PWRSRTEYPG YNPNAGVTRR ASDPARAADH PAPARVQRFK 

       670        680        690        700        710        720 
SLGCVHTPPS VATGRNFDPH HPTSVYSPQP PSITENVAMD TRGLQEEPEV GTSVMGNGLN 

       730        740        750        760        770        780 
PYMDFSSTDT LGYGGPEGTA AEPYEARGPG SLPLGPGPPT NYGPGHCAQQ VSYPDPTPEN 

       790        800        810        820        830        840 
WGEFPSHAGV YPSNKAPGAA YSQCPRLEHY GQVQVKPEQG CPVGSDSTGL APCLNAHPSE 

       850        860        870        880        890        900 
GSPGPQPLFS HHPQLPQPQY PQSGPYPQPP HGYLSTEPRL GLNFNPSSSH STGQLKAQLV 

       910        920        930        940        950        960 
CNYVQSQQEL LWEGRNRGGL PNQELPYQSP KFLGGSQVSQ SPAKTPAAAA AAYGSGFAPA 

       970        980        990       1000       1010       1020 
SANHKSGSYP APSPCHETFT VGVNRPSHRP AAPPRLLPPL SPCYGPLKVG DTNPSCGHPE 

      1030       1040       1050       1060       1070       1080 
VGRLGAGPAL YPPPEGQVCN ALDSLDLDNT QLDFVAILDE AQGLSPPLSH EQGDSSKNTP 

      1090       1100       1110 
SPSGPPNMAV GNMSVLLGSL PGETQFLNSS A

P47806 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools