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UniProtKB/Swiss-Prot entry P47736


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RPGP1_HUMAN
Primary accession number P47736
Secondary accession numbers O75062 Q5T3T4
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on November 25, 2008 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 72)
Name and origin of the protein
Protein name Rap1 GTPase-activating protein 1
Synonyms Rap1GAP1
Rap1GAP
Gene name
Name: RAP1GAP
Synonyms: KIAA0474, RAP1GA1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT THR-107.
TISSUE=Brain;
DOI=10.1016/0092-8674(91)90555-D; PubMed=1904317 [NCBI, ExPASy, EBI, Israel, Japan]
Rubinfeld B., Munemitsu S., Clark R., Conroy L., Watt K., Crosier W.J., McCormick F., Polakis P.;
"Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1.";
Cell 65:1033-1042(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
DOI=10.1093/dnares/4.5.345; PubMed=9455484 [NCBI, ExPASy, EBI, Israel, Japan]
Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.;
"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.";
DNA Res. 4:345-349(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
TISSUE SPECIFICITY, AND INDUCTION.
DOI=10.1074/jbc.272.44.28081; PubMed=9346962 [NCBI, ExPASy, EBI, Israel, Japan]
Kurachi H., Wada Y., Tsukamoto N., Maeda M., Kubota H., Hattori M., Iwai K., Minato N.;
"Human SPA-1 product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2.";
J. Biol. Chem. 272:28081-28088(1997).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-484 AND SER-499, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[7]
VARIANTS [LARGE SCALE ANALYSIS] ARG-257 AND CYS-609.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M64788; AAA60252.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB007943; BAA32319.3; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL359815; CAI16250.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471134; EAW94980.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00386930; -.
IPI00843926; -.
PIR A39897; A39897.
B39897; B39897.
RefSeq NP_001139129.1; -.
NP_002876.2; -.
UniGene Hs.148178
3D structure databases
PDB
1SRQ; X-ray; 2.90 A; A/B/C/D=75-415.[ExPASy / RCSB / EBI]
3BRW; X-ray; 3.40 A; A/B/C=75-415.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1SRQ; -.
3BRW; -.
ModBase P47736.
Protein-protein interaction databases
IntAct P47736; 2.
PTM databases
PhosphoSite P47736; -.
Organism-specific databases
GeneCards GC01M021796; -.
H-InvDB HIX0000226; -.
HGNC HGNC:9858; RAP1GAP.
GenAtlas RAP1GAP.
HPA CAB003851; -.
HPA001922; -.
MIM 600278; gene. [NCBI / EBI]
HUGE KIAA0474.
Gene expression databases
ArrayExpress P47736; -.
Bgee P47736; -.
CleanEx HS_RAP1GAP; -.
GermOnline ENSG00000076864; Homo sapiens.
Ontologies
GO
GO:0000139; Cellular component: Golgi membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005634; Cellular component: nucleus (inferred from direct assay from HPA).
GO:0005096; Molecular function: GTPase activator activity (traceable author statement from ProtInc).
GO:0051056; Biological process: regulation of small GTPase mediated signal transduction (inferred from electronic annotation from InterPro).
GO:0007165; Biological process: signal transduction (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR003109; GoLoco_motif.
IPR000331; Rap_GAP.
Graphical view of domain structure.
Pfam PF02188; GoLoco; 1.
PF02145; Rap_GAP; 1.
Pfam graphical view of domain structure.
SMART SM00390; GoLoco; 1.
SMART graphical view of domain structure.
PROSITE PS50877; GOLOCO; 1.
PS50085; RAPGAP; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P47736; -.
Genome annotation databases
Ensembl ENSG00000076864; Homo sapiens. [Contig view]
GeneID 5909; -.
KEGG hsa:5909; -.
Phylogenomic databases
HOVERGEN P47736; -.
Other
NextBio 22986; -.
SOURCE RAP1GAP; Homo sapiens.
ProtoNet P47736.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Golgi apparatus; GTPase activation; Membrane; Phosphoprotein; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   663  663     Rap1 GTPase-activating protein 1. PRO_0000056743
DOMAIN   1    17  17     GoLoco. 
DOMAIN   181   397  217     Rap-GAP. 
MOD_RES   484   484        Phosphoserine. 
MOD_RES   499   499        Phosphoserine. 
VAR_SEQ   476   476        I -> ISLLIPGKSASRFGRRGSAIGIGTVEE (in isoform 2). VSP_035256
VAR_SEQ   626   633        Missing (in isoform 2). VSP_035257
VARIANT   107   107  1     A -> T (in dbSNP:rs2275363 [NCBI]). VAR_047792 
VARIANT   257   257  1     C -> R (in a breast cancer sample; somatic mutation). VAR_035547 
VARIANT   609   609  1     Y -> C (in a breast cancer sample; somatic mutation). VAR_035548 
HELIX   85    88  4      
HELIX   89    93  5      
TURN   94    96  3      
STRAND   100   106  7      
TURN   107   109  3      
STRAND   110   121  12      
STRAND   124   132  9      
STRAND   137   143  7      
HELIX   153   160  8      
HELIX   177   186  10      
STRAND   192   200  9      
HELIX   207   211  5      
HELIX   218   227  10      
STRAND   228   233  6      
STRAND   245   247  3      
STRAND   252   258  7      
STRAND   263   268  6      
HELIX   269   271  3      
HELIX   282   288  7      
STRAND   292   300  9      
HELIX   306   308  3      
STRAND   316   323  8      
STRAND   331   338  8      
STRAND   354   358  5      
HELIX   359   376  18      
HELIX   380   409  30      
Sequence information
Length: 663 AA [This is the length of the unprocessed precursor] Molecular weight: 73361 Da [This is the MW of the unprocessed precursor] CRC64: 89B307CC67F975DD [This is a checksum on the sequence]
        10         20         30         40         50         60 
MIEKMQGSRM DEQRCSFPPP LKTEEDYIPY PSVHEVLGRE GPFPLILLPQ FGGYWIEGTN 

        70         80         90        100        110        120 
HEITSIPETE PLQSPTTKVK LECNPTARIY RKHFLGKEHF NYYSLDAALG HLVFSLKYDV 

       130        140        150        160        170        180 
IGDQEHLRLL LRTKCRTYHD VIPISCLTEF PNVVQMAKLV CEDVNVDRFY PVLYPKASRL 

       190        200        210        220        230        240 
IVTFDEHVIS NNFKFGVIYQ KLGQTSEEEL FSTNEESPAF VEFLEFLGQK VKLQDFKGFR 

       250        260        270        280        290        300 
GGLDVTHGQT GTESVYCNFR NKEIMFHVST KLPYTEGDAQ QLQRKRHIGN DIVAVVFQDE 

       310        320        330        340        350        360 
NTPFVPDMIA SNFLHAYVVV QAEGGGPDGP LYKVSVTARD DVPFFGPPLP DPAVFRKGPE 

       370        380        390        400        410        420 
FQEFLLTKLI NAEYACYKAE KFAKLEERTR AALLETLYEE LHIHSQSMMG LGGDEDKMEN 

       430        440        450        460        470        480 
GSGGGGFFES FKRVIRSRSQ SMDAMGLSNK KPNTVSTSHS GSFAPNNPDL AKAAGISLIV 

       490        500        510        520        530        540 
PGKSPTRKKS GPFGSRRSSA IGIENIQEVQ EKRESPPAGQ KTPDSGHVSQ EPKSENSSTQ 

       550        560        570        580        590        600 
SSPEMPTTKN RAETAAQRAE ALKDFSRSSS SASSFASVVE ETEGVDGEDT GLESVSSSGT 

       610        620        630        640        650        660 
PHKRDSFIYS TWLEDSVSTT SGGSSPGPSR SPHPDAGKLG DPACPEIKIQ LEASEQHMPQ 


LGC 

P47736 in FASTA format

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