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UniProtKB/Swiss-Prot entry P47051

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LPLA_YEAST
Primary accession number P47051
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on February 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 52)
Name and origin of the protein
Protein name Putative lipoate-protein ligase A
Synonyms EC 2.7.7.63
Altered inheritance rate of mitochondria protein 22
Gene name
Name: AIM22
OrderedLocusNames: YJL046W
ORFNames: J1171
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=8641269 [NCBI, ExPASy, EBI, Israel, Japan]
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
EMBO J. 15:2031-2049(1996).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
DOI=10.1101/gr.6037607; PubMed=17322287 [NCBI, ExPASy, EBI, Israel, Japan]
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z49321; CAA89337.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY558080; AAS56406.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S56818; S56818.
3D structure databases
ModBase P47051.
Organism-specific databases
CYGD YJL046w; -.
SGD S000003582; AIM22.
Yeast-GFP YJL046W.
Gene expression databases
ArrayExpress P47051; -.
GermOnline YJL046W; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0016874; Molecular function: ligase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0016740; Molecular function: transferase activity (inferred from electronic annotation from InterPro).
GO:0009249; Biological process: protein lipoylation (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR004143; BPL_LipA_LipB.
IPR004562; Lipoyltrans.
Graphical view of domain structure.
Pfam PF03099; BPL_LipA_LipB; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00545; lipoyltrans; 1.
Genome annotation databases
Ensembl YJL046W; Saccharomyces cerevisiae. [Contig view]
GenomeReviews Y13136_GR; YJL046W.
NMPDR fig|4932.3.peg.3463; -.
Phylogenomic databases
HOGENOM P47051; -.
Other
LinkHub P47051; -.
ProtoNet P47051.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   451  451     Putative lipoate-protein ligase A. PRO_0000203066
NP_BIND   235   238  4     ATP (By similarity). 
BINDING   230   230        ATP (By similarity). 
BINDING   291   291        ATP (By similarity). 
BINDING   291   291        Lipoate (By similarity). 
Sequence information
Length: 451 AA [This is the length of the unprocessed precursor] Molecular weight: 52085 Da [This is the MW of the unprocessed precursor] CRC64: 637673A018B865AE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRSASSYLIR NIEHPKISEL TYVEFLMNTK EENTRLFFDV YIMSMMLSNW ALSPRYVGQR 

        70         80         90        100        110        120 
NLIHCTTLFH TLTRWAKDAD DKYHDINSMY ENMFTPSNDN VSILQDEGKS DYDTTKASSM 

       130        140        150        160        170        180 
EEDISAFNKD LYNFYNIGYA KQIMSASQLE NIVKAKGRFV IQSLSTSPYY NLALENYVFK 

       190        200        210        220        230        240 
NTPRAKRGPD NCRLLFYIND RCAVIGKNQN LWQEVDLAKL KSKNFELLRR FSGGGTVLHD 

       250        260        270        280        290        300 
LGNVNYSYLT SREKFETKFF NKMIIKWLNS LNPELRLDLN ERGDIIQDGF KISGSAYKIA 

       310        320        330        340        350        360 
GGKAYHHATM LLNADLEQFS GLLEPSLPNN MEWESSGVHS VKSKIKNVGI ITPNQFIAVV 

       370        380        390        400        410        420 
SERFQKTFKV DGEIPIYYCD EFKSINDEIK DAMNTLQSEQ WKYFSGPKFS VKIKDKGLTI 

       430        440        450 
KVEKGMIYDC DRNDLIGLEF KGFLENIDSY T
P47051 in FASTA format

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