ID APBB1_RAT Reviewed; 711 AA. AC P46933; Q99MK3; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 27-SEP-2004, sequence version 3. DT 22-JUL-2008, entry version 55. DE RecName: Full=Amyloid beta A4 precursor protein-binding family B member 1; DE AltName: Full=Fe65 protein; GN Name=Apbb1; Synonyms=Fe65; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RA Cao X., Suedhof T.C.; RT "Nuclear signaling of APP cytoplasmic tail."; RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 121-711 (ISOFORM 2). RC TISSUE=Brain; RX MEDLINE=92020215; PubMed=1923810; DOI=10.1093/nar/19.19.5269; RA Duilio A., Zambrano N., Mogavero A.R., Ammendola R., Cimino F., RA Russo T.; RT "A rat brain mRNA encoding a transcriptional activator homologous to RT the DNA binding domain of retroviral integrases."; RL Nucleic Acids Res. 19:5269-5274(1991). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 243-530. RC TISSUE=Brain; RX MEDLINE=95098600; PubMed=7800475; DOI=10.1093/nar/22.23.4876; RA Faraonio R., Minopoli G., Porcellini A., Costanzo F., Cimino F., RA Russo T.; RT "The DNA sequence encompassing the transcription start site of a TATA- RT less promoter contains enough information to drive neuron-specific RT transcription."; RL Nucleic Acids Res. 22:4876-4883(1994). CC -!- FUNCTION: May modulate the internalization of beta-amyloid CC precursor protein (By similarity). CC -!- SUBUNIT: Binds to the intracellular domain of the beta-amyloid CC precursor protein. Interacts, through the WW domain, with proline- CC rich regions of APBB1IP and ENAH (By similarity). CC -!- INTERACTION: CC P05067:APP (xeno); NbExp=1; IntAct=EBI-286177, EBI-77613; CC P08592:App; NbExp=1; IntAct=EBI-286177, EBI-286155; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; Synonyms=Long; CC IsoId=P46933-1; Sequence=Displayed; CC Name=2; Synonyms=Short; CC IsoId=P46933-2; Sequence=VSP_006798; CC -!- TISSUE SPECIFICITY: Brain, not in liver, very low in other CC tissues. The long (neuron-specific) form is expressed only in CC brain. CC -!- SIMILARITY: Contains 2 PID domains. CC -!- SIMILARITY: Contains 1 WW domain. CC -!- SEQUENCE CAUTION: CC Sequence=CAA42999.1; Type=Frameshift; Positions=127; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF333983; AAK20835.1; -; mRNA. DR EMBL; X60469; CAA42999.1; ALT_FRAME; mRNA. DR EMBL; X60468; CAA42998.1; -; mRNA. DR PIR; S22571; S22571. DR PIR; S50818; S50818. DR RefSeq; NP_536726.1; -. DR UniGene; Rn.19953; -. DR SMR; P46933; 242-291. DR DIP; DIP:682N; -. DR IntAct; P46933; -. DR PhosphoSite; P46933; -. DR Ensembl; ENSRNOG00000018020; Rattus norvegicus. DR GeneID; 29722; -. DR KEGG; rno:29722; -. DR RGD; 2122; Apbb1. DR HOVERGEN; P46933; -. DR GermOnline; ENSRNOG00000018020; Rattus norvegicus. DR GO; GO:0030426; C:growth cone; ISS:UniProtKB. DR GO; GO:0030027; C:lamellipodium; ISS:UniProtKB. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0045202; C:synapse; ISS:UniProtKB. DR GO; GO:0001540; F:beta-amyloid binding; ISS:UniProtKB. DR GO; GO:0008134; F:transcription factor binding; ISS:UniProtKB. DR GO; GO:0007050; P:cell cycle arrest; ISS:UniProtKB. DR GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB. DR GO; GO:0045749; P:negative regulation of S phase of mitotic c...; ISS:UniProtKB. DR GO; GO:0050760; P:negative regulation of thymidylate synthase...; ISS:UniProtKB. DR GO; GO:0045449; P:regulation of transcription; ISS:UniProtKB. DR InterPro; IPR011993; PH_type. DR InterPro; IPR006020; PTB_PID. DR InterPro; IPR001202; WW_Rsp5_WWP. DR Gene3D; G3DSA:2.30.29.30; PH_type; 2. DR Pfam; PF00640; PID; 2. DR Pfam; PF00397; WW; 1. DR SMART; SM00462; PTB; 2. DR SMART; SM00456; WW; 1. DR PROSITE; PS01179; PID; 2. DR PROSITE; PS01159; WW_DOMAIN_1; 1. DR PROSITE; PS50020; WW_DOMAIN_2; 1. PE 1: Evidence at protein level; KW Alternative splicing; Repeat. FT CHAIN 1 711 Amyloid beta A4 precursor protein-binding FT family B member 1. FT /FTId=PRO_0000076051. FT DOMAIN 254 286 WW. FT DOMAIN 365 533 PID 1. FT DOMAIN 538 700 PID 2. FT COMPBIAS 148 188 Glu-rich. FT VAR_SEQ 463 464 Missing (in isoform 2). FT /FTId=VSP_006798. FT CONFLICT 137 137 L -> K (in Ref. 2). FT CONFLICT 150 154 EEKAA -> GRRQR (in Ref. 2). FT CONFLICT 172 172 E -> EEEDEEEE (in Ref. 2). SQ SEQUENCE 711 AA; 77656 MW; A6C9820F5D2BD7BE CRC64; MSVPSSLSQS AINANSHGGP ALSFPFPLHA AHNQLLNAKL QATAVVPKDL RSAMGEGSVP EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS QEAETAPLGP KGLMHLYSEL ELSAHNAANR GLHGSALIIN TQGLGPDEGE EKAAGEVEEE DEDEEEEDEE EEDLSSPQGL PEPLENVEVP SGPQVLTDGP REHSKSASLL FGMRNSAASD EDSSWATLSQ GSPSYGSPED TDSFWNPNAF ETDSDLPAGW MRVQDTSGTY YWHIPTGTTQ WEPPGRASPS QGNSPQEESQ LTWTGFAHQE GFEEGEFWKD EPSEEAPMEL GLKDPEEGTL PFSAQSLSPE PVPQEEENLP QRNANPGIKC FAVRSLGWVE MTEEELAPGR SSVAVNNCIR QLSYHKNNLH DPMSGGWGEG KDLLLQLEDE TLKLVEPQNQ TLLHAQPIVS IRVWGVGRDS GRERDFAYVA RDKLTQMLKC HVFRCEAPAK NIATSLHEIC SKIMSERRNA RCLVNGLSLD HSKLVDVPFQ VEFPAPKNEL VQKFQVYYLG NVPVAKPVGV DVINGALESV LSSSSREQWT PSHVSVAPAT LTILHQQTEA VLGECRVRFL SFLAVGRDVH TFAFIMAAGP ASFCCHMFWC EPNAASLSEA VQAACMLRYQ KCLDARSQTS TSCLPAPPAE SVARRVGWTV RRGVQSLWGS LKPKRLGSQT P //