ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P46695


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name IEX1_HUMAN
Primary accession number P46695
Secondary accession numbers Q92691 Q93044
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on July 15, 1998 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 75)
Name and origin of the protein
Protein name Radiation-inducible immediate-early gene IEX-1
Synonyms Immediate early protein GLY96
Immediate early response 3 protein
PACAP-responsive gene 1 protein
Protein PRG1
Differentiation-dependent gene 2 protein
Protein DIF-2
Gene name
Name: IER3
Synonyms: DIF2, IEX1, PRG1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
PubMed=8603392 [NCBI, ExPASy, EBI, Israel, Japan]
Kondratyev A.D., Chung K.-N., Jung M.O.;
"Identification and characterization of a radiation-inducible glycosylated human early-response gene.";
Cancer Res. 56:1498-1502(1996).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8653710 [NCBI, ExPASy, EBI, Israel, Japan]
Schaefer H., Trauzold A., Siegel E.G., Folsch U.R., Schmidt W.E.;
"PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line.";
Cancer Res. 56:2641-2648(1996).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/bbrc.1997.6715; PubMed=9196025 [NCBI, ExPASy, EBI, Israel, Japan]
Pietzsch A., Buechler C., Aslanidis C., Schmitz G.;
"Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine.";
Biochem. Biophys. Res. Commun. 235:4-9(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Shiina S., Tamiya G., Oka A., Inoko H.;
"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
S81914; AAB36278.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X96438; CAA65304.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14551; CAA74886.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000025; BAB63319.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT006703; AAP35349.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000844; AAH00844.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC005080; AAH05080.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00007831; -.
PIR JC5537; JC5537.
RefSeq NP_003888.2; -.
UniGene Hs.591785
3D structure databases
ModBase P46695.
Protein-protein interaction databases
IntAct P46695; 4.
PTM databases
PhosphoSite P46695; -.
Organism-specific databases
GeneCards GC06M030818; -.
GC06Mc30848; -.
GC06Mf30843; -.
H-InvDB HIX0005703; -.
HIX0057742; -.
HIX0058162; -.
HGNC HGNC:5392; IER3.
GenAtlas IER3.
MIM 602996; gene. [NCBI / EBI]
PharmGKB PA29639; -.
Gene expression databases
CleanEx HS_IER3; -.
GermOnline ENSG00000137331; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0009653; Biological process: anatomical structure morphogenesis (traceable author statement from ProtInc).
GO:0006916; Biological process: anti-apoptosis (traceable author statement from ProtInc).
GO:0006915; Biological process: apoptosis (traceable author statement from ProtInc).
QuickGo view.
Proteomic databases
PRIDE P46695; -.
Genome annotation databases
Ensembl ENSG00000206377; Homo sapiens. [Contig view]
ENSG00000206478; Homo sapiens. [Contig view]
GeneID 8870; -.
KEGG hsa:8870; -.
Phylogenomic databases
HOVERGEN P46695; -.
Other
NextBio 33301; -.
SOURCE IER3; Homo sapiens.
ProtoNet P46695.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Membrane; Signal-anchor; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   156  156     Radiation-inducible immediate-early gene IEX-1. PRO_0000084159
TOPO_DOM   1    82  82     Cytoplasmic (Potential). 
TRANSMEM   83    99  17     Signal-anchor for type II membrane protein (Potential). 
TOPO_DOM   100   156  57     Extracellular (Potential). 
CARBOHYD   133   133        N-linked (GlcNAc...) (Potential). 
CONFLICT   54    54        A -> G (in Ref. 1; AAB36278). 
CONFLICT   106   106        P -> R (in Ref. 1; AAB36278). 
Sequence information
Length: 156 AA [This is the length of the unprocessed precursor] Molecular weight: 16929 Da [This is the MW of the unprocessed precursor] CRC64: 83C06116C80B9240 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MCHSRSCHPT MTILQAPTPA PSTIPGPRRG SGPEIFTFDP LPEPAAAPAG RPSASRGHRK 

        70         80         90        100        110        120 
RSRRVLYPRV VRRQLPVEEP NPAKRLLFLL LTIVFCQILM AEEGVPAPLP PEDAPNAASL 

       130        140        150 
APTPVSPVLE PFNLTSEPSD YALDLSTFLQ QHPAAF 

P46695 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!