[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
Mann R.S.,
Blaumueller C.M.,
Zagouras P.;
"Complete human notch 1 (hN1) cDNA sequence.";
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02465; PubMed=15164053 [NCBI, ExPASy, EBI, Israel, Japan]
Humphray S.J.,
Oliver K.,
Hunt A.R.,
Plumb R.W.,
Loveland J.E.,
Howe K.L.,
Andrews T.D.,
Searle S.,
Hunt S.E.,
Scott C.E.,
Jones M.C.,
Ainscough R.,
Almeida J.P.,
Ambrose K.D.,
Ashwell R.I.S.,
Babbage A.K.,
Babbage S.,
Bagguley C.L.,
Bailey J., ![]()
Banerjee R.,
Barker D.J.,
Barlow K.F.,
Bates K.,
Beasley H.,
Beasley O.,
Bird C.P.,
Bray-Allen S.,
Brown A.J.,
Brown J.Y.,
Burford D.,
Burrill W.,
Burton J.,
Carder C.,
Carter N.P.,
Chapman J.C.,
Chen Y.,
Clarke G.,
Clark S.Y.,
Clee C.M.,
Clegg S.,
Collier R.E.,
Corby N.,
Crosier M.,
Cummings A.T.,
Davies J.,
Dhami P.,
Dunn M.,
Dutta I.,
Dyer L.W.,
Earthrowl M.E.,
Faulkner L.,
Fleming C.J.,
Frankish A.,
Frankland J.A.,
French L.,
Fricker D.G.,
Garner P.,
Garnett J.,
Ghori J.,
Gilbert J.G.R.,
Glison C.,
Grafham D.V.,
Gribble S.,
Griffiths C.,
Griffiths-Jones S.,
Grocock R.,
Guy J.,
Hall R.E.,
Hammond S.,
Harley J.L.,
Harrison E.S.I.,
Hart E.A.,
Heath P.D.,
Henderson C.D.,
Hopkins B.L.,
Howard P.J.,
Howden P.J.,
Huckle E.,
Johnson C.,
Johnson D.,
Joy A.A.,
Kay M.,
Keenan S.,
Kershaw J.K.,
Kimberley A.M.,
King A.,
Knights A.,
Laird G.K.,
Langford C.,
Lawlor S.,
Leongamornlert D.A.,
Leversha M.,
Lloyd C.,
Lloyd D.M.,
Lovell J.,
Martin S.,
Mashreghi-Mohammadi M.,
Matthews L.,
McLaren S.,
McLay K.E.,
McMurray A.,
Milne S.,
Nickerson T.,
Nisbett J.,
Nordsiek G.,
Pearce A.V.,
Peck A.I.,
Porter K.M.,
Pandian R.,
Pelan S.,
Phillimore B.,
Povey S.,
Ramsey Y.,
Rand V.,
Scharfe M.,
Sehra H.K.,
Shownkeen R.,
Sims S.K.,
Skuce C.D.,
Smith M.,
Steward C.A.,
Swarbreck D.,
Sycamore N.,
Tester J.,
Thorpe A.,
Tracey A.,
Tromans A.,
Thomas D.W.,
Wall M.,
Wallis J.M.,
West A.P.,
Whitehead S.L.,
Willey D.L.,
Williams S.A.,
Wilming L.,
Wray P.W.,
Young L.,
Ashurst J.L.,
Coulson A.,
Blocker H.,
Durbin R.M.,
Sulston J.E.,
Hubbard T.,
Jackson M.J.,
Bentley D.R.,
Beck S.,
Rogers J.,
Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1-2443.
DOI=10.1016/0092-8674(91)90111-B; PubMed=1831692 [NCBI, ExPASy, EBI, Israel, Japan]
Ellisen L.W.,
Bird J.,
West D.C.,
Soreng A.L.,
Reynolds T.C.,
Smith S.D.,
Sklar J.;
"TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.";
Cell 66:649-661(1991).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 489-2555.
TISSUE=Aortic endothelium;
Totoki Y.,
Toyoda A.,
Takeda T.,
Sakaki Y.,
Tanaka A.,
Yokoyama S.,
Ohara O.,
Nagase T.,
Kikuno R.F.;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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[5]
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IDENTIFICATION OF LIGANDS.
PubMed=10079256 [NCBI, ExPASy, EBI, Israel, Japan]
Gray G.E.,
Mann R.S.,
Mitsiadis E.,
Henrique D.,
Carcangiu M.-L.,
Banks A.,
Leiman J.,
Ward D.,
Ish-Horowitz D.,
Artavanis-Tsakonas S.;
"Human ligands of the Notch receptor.";
Am. J. Pathol. 154:785-794(1999).
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[6]
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INTERACTION WITH DTX1.
DOI=10.1038/ng0598-74; PubMed=9590294 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuno K.,
Eastman D.,
Mitsiades T.,
Quinn A.M.,
Carcanciu M.L.,
Ordentlich P.,
Kadesch T.,
Artavanis-Tsakonas S.;
"Human deltex is a conserved regulator of Notch signalling.";
Nat. Genet. 19:74-78(1998).
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[7]
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INTERACTION WITH MAML1.
DOI=10.1038/82644; PubMed=11101851 [NCBI, ExPASy, EBI, Israel, Japan]
Wu L.,
Aster J.C.,
Blacklow S.C.,
Lake R.,
Artavanis-Tsakonas S.,
Griffin J.D.;
"MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.";
Nat. Genet. 26:484-489(2000).
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[8]
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INTERACTION WITH MAML2 AND MAML3.
DOI=10.1128/MCB.22.21.7688-7700.2002; PubMed=12370315 [NCBI, ExPASy, EBI, Israel, Japan]
Wu L.,
Sun T.,
Kobayashi K.,
Gao P.,
Griffin J.D.;
"Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.";
Mol. Cell. Biol. 22:7688-7700(2002).
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[9]
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STRUCTURE BY NMR OF 1446-1480 IN COMPLEX WITH CALCIUM IONS, AND DISULFIDE BONDS.
DOI=10.1021/bi034156y; PubMed=12795601 [NCBI, ExPASy, EBI, Israel, Japan]
Vardar D.,
North C.L.,
Sanchez-Irizarry C.,
Aster J.C.,
Blacklow S.C.;
"Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1.";
Biochemistry 42:7061-7067(2003).
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[10]
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STRUCTURE BY NMR OF 411-526.
DOI=10.1016/j.str.2004.09.012; PubMed=15576031 [NCBI, ExPASy, EBI, Israel, Japan]
Hambleton S.,
Valeyev N.V.,
Muranyi A.,
Knott V.,
Werner J.M.,
McMichael A.J.,
Handford P.A.,
Downing A.K.;
"Structural and functional properties of the human notch-1 ligand binding region.";
Structure 12:2173-2183(2004).
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[11]
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X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1872-2114.
DOI=10.1042/BJ20050515; PubMed=16011479 [NCBI, ExPASy, EBI, Israel, Japan]
Ehebauer M.T.,
Chirgadze D.Y.,
Hayward P.,
Martinez Arias A.,
Blundell T.L.;
"High-resolution crystal structure of the human Notch 1 ankyrin domain.";
Biochem. J. 392:13-20(2005).
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[12]
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X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 1872-2126 IN COMPLEX WITH RBPSUH AND MAML1.
DOI=10.1016/j.cell.2005.12.037; PubMed=16530044 [NCBI, ExPASy, EBI, Israel, Japan]
Nam Y.,
Sliz P.,
Song L.,
Aster J.C.,
Blacklow S.C.;
"Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.";
Cell 124:973-983(2006).
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[13]
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INVOLVEMENT IN AORTIC VALVE DISEASE.
DOI=10.1038/nature03940; PubMed=16025100 [NCBI, ExPASy, EBI, Israel, Japan]
Garg V.,
Muth A.N.,
Ransom J.F.,
Schluterman M.K.,
Barnes R.,
King I.N.,
Grossfeld P.D.,
Srivastava D.;
"Mutations in NOTCH1 cause aortic valve disease.";
Nature 437:270-274(2005).
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