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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1038/365855a0; PubMed=8413673 [NCBI, ExPASy, EBI, Israel, Japan]
Chrivia J.C.,
Kwok R.P.S.,
Lamb N.,
Hagiwara M.,
Montminy M.R.,
Goodman R.H.;
"Phosphorylated CREB binds specifically to the nuclear protein CBP.";
Nature 365:855-859(1993).
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[2]
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INTERACTION WITH NCOA1.
DOI=10.1016/S0092-8674(00)81118-6; PubMed=8616895 [NCBI, ExPASy, EBI, Israel, Japan]
Kamei Y.,
Xu L.,
Heinzel T.,
Torchia J.,
Kurokawa R.,
Gloss B.,
Lin S.-C.,
Heyman R.A.,
Rose D.W.,
Glass C.K.,
Rosenfeld M.G.;
"A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.";
Cell 85:403-414(1996).
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[3]
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INTERACTION WITH CREB1, AND MUTAGENESIS OF ARG-600.
PubMed=8552098 [NCBI, ExPASy, EBI, Israel, Japan]
Parker D.,
Ferreri K.,
Nakajima T.,
LaMorte V.J.,
Evans R.,
Koerber S.C.,
Hoeger C.,
Montminy M.R.;
"Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism.";
Mol. Cell. Biol. 16:694-703(1996).
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[4]
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INTERACTION WITH NCOA3.
DOI=10.1038/42652; PubMed=9192892 [NCBI, ExPASy, EBI, Israel, Japan]
Torchia J.,
Rose D.W.,
Inostroza J.,
Kamei Y.,
Westin S.,
Glass C.K.,
Rosenfeld M.G.;
"The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.";
Nature 387:677-684(1997).
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[5]
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INTERACTION WITH CARM1, METHYLATION AT ARG-600 AND ARG-624, AND FUNCTION.
DOI=10.1126/science.1065961; PubMed=11701890 [NCBI, ExPASy, EBI, Israel, Japan]
Xu W.,
Chen H.,
Du K.,
Asahara H.,
Tini M.,
Emerson B.M.,
Montminy M.,
Evans R.M.;
"A transcriptional switch mediated by cofactor methylation.";
Science 294:2507-2511(2001).
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[6]
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INTERACTION WITH CITED4.
DOI=10.1006/geno.2002.7005; PubMed=12504852 [NCBI, ExPASy, EBI, Israel, Japan]
Yahata T.,
Takedatsu H.,
Dunwoodie S.L.,
Braganca J.,
Swingler T.,
Withington S.L.,
Hur J.,
Coser K.R.,
Isselbacher K.J.,
Bhattacharya S.,
Shioda T.;
"Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells.";
Genomics 80:601-613(2002).
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[7]
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INTERACTION WITH ZCCHC12.
DOI=10.1128/MCB.01038-07; PubMed=18160706 [NCBI, ExPASy, EBI, Israel, Japan]
Cho G.,
Lim Y.,
Zand D.,
Golden J.A.;
"Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling.";
Mol. Cell. Biol. 28:1565-1572(2008).
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- FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes (By similarity).
- CATALYTIC ACTIVITY: Acetyl-CoA + histone = CoA + acetylhistone.
- SUBUNIT: Found in a complex containing NCOA2; NCOA3; IKKA; IKKB and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with phosphorylated CREB1. Interacts with the C-terminal region of CITED4. The TAZ-type 1 domain interacts with HIF1A. Interacts with SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB, TRERF1 and ZCCHC12. Interacts with KLF1; the interaction results in acetylation and enhancement of transcriptional activity of KLF1 (By similarity).
- INTERACTION:
P88946:- (xeno); NbExp=4; IntAct=EBI-296306, EBI-936023;
P16220:CREB1 (xeno); NbExp=1; IntAct=EBI-296306, EBI-711855;
Q60749:Khdrbs1; NbExp=3; IntAct=EBI-296306, EBI-519077;
P10242:MYB (xeno); NbExp=1; IntAct=EBI-296306, EBI-298355;
Q04207:Rela; NbExp=1; IntAct=EBI-296306, EBI-644400;
P36956-1:SREBF1 (xeno); NbExp=1; IntAct=EBI-296306, EBI-948328;
Q64451:Trp53; NbExp=1; IntAct=EBI-296306, EBI-493476;
Q9EPK5:Wwtr1; NbExp=1; IntAct=EBI-296306, EBI-1211920;
- SUBCELLULAR LOCATION: Nucleus.
- PTM: Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response.
- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).
- SIMILARITY: Contains 1 bromo domain.
- SIMILARITY: Contains 1 KIX domain.
- SIMILARITY: Contains 2 TAZ-type zinc fingers.
- SIMILARITY: Contains 1 ZZ-type zinc finger.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 2441 AA [This is the length of the unprocessed precursor] |
Molecular weight: 265474 Da [This is the MW of the unprocessed precursor] |
CRC64: 0ABB028C3112F419 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAENLLDGPP NPKRAKLSSP GFSANDNTDF GSLFDLENDL PDELIPNGEL SLLNSGNLVP
70 80 90 100 110 120
DAASKHKQLS ELLRGGSGSS INPGIGNVSA SSPVQQGLGG QAQGQPNSTN MASLGAMGKS
130 140 150 160 170 180
PLNQGDSSTP NLPKQAASTS GPTPPASQAL NPQAQKQVGL VTSSPATSQT GPGICMNANF
190 200 210 220 230 240
NQTHPGLLNS NSGHSLMNQA QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE
250 260 270 280 290 300
TLTQVSPQMA GHAGLNTAQA GGMTKMGMTG TTSPFGQPFS QTGGQQMGAT GVNPQLASKQ
310 320 330 340 350 360
SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPTQAIA TGPTADPEKR KLIQQQLVLL
370 380 390 400 410 420
LHAHKCQRRE QANGEVRACS LPHCRTMKNV LNHMTHCQAP KACQVAHCAS SRQIISHWKN
430 440 450 460 470 480
CTRHDCPVCL PLKNASDKRN QQTILGSPAS GIQNTIGSVG AGQQNATSLS NPNPIDPSSM
490 500 510 520 530 540
QRAYAALGLP YMNQPQTQLQ PQVPGQQPAQ PPAHQQMRTL NALGNNPMSV PAGGITTDQQ
550 560 570 580 590 600
PPNLISESAL PTSLGATNPL MNDGSNSGNI GSLSTIPTAA PPSSTGVRKG WHEHVTQDLR
610 620 630 640 650 660
SHLVHKLVQA IFPTPDPAAL KDRRMENLVA YAKKVEGDMY ESANSRDEYY HLLAEKIYKI
670 680 690 700 710 720
QKELEEKRRT RLHKQGILGN QPALPASGAQ PPVIPPAQSV RPPNGPLPLP VNRMQVSQGM
730 740 750 760 770 780
NSFNPMSLGN VQLPQAPMGP RAASPMNHSV QMNSMASVPG MAISPSRMPQ PPNMMGTHAN
790 800 810 820 830 840
NIMAQAPTQN QFLPQNQFPS SSGAMSVNSV GMGQPAAQAG VSQGQEPGAA LPNPLNMLAP
850 860 870 880 890 900
QASQLPCPPV TQSPLHPTPP PASTAAGMPS LQHPTAPGMT PPQPAAPTQP STPVSSGQTP
910 920 930 940 950 960
TPTPGSVPSA AQTQSTPTVQ AAAQAQVTPQ PQTPVQPPSV ATPQSSQQQP TPVHTQPPGT
970 980 990 1000 1010 1020
PLSQAAASID NRVPTPSTVT SAETSSQQPG PDVPMLEMKT EVQTDDAEPE PTESKGEPRS
1030 1040 1050 1060 1070 1080
EMMEEDLQGS SQVKEETDTT EQKSEPMEVE EKKPEVKVEA KEEEENSSND TASQSTSPSQ
1090 1100 1110 1120 1130 1140
PRKKIFKPEE LRQALMPTLE ALYRQDPESL PFRQPVDPQL LGIPDYFDIV KNPMDLSTIK
1150 1160 1170 1180 1190 1200
RKLDTGQYQE PWQYVDDVRL MFNNAWLYNR KTSRVYKFCS KLAEVFEQEI DPVMQSLGYC
1210 1220 1230 1240 1250 1260
CGRKYEFSPQ TLCCYGKQLC TIPRDAAYYS YQNRYHFCGK CFTEIQGENV TLGDDPSQPQ
1270 1280 1290 1300 1310 1320
TTISKDQFEK KKNDTLDPEP FVDCKECGRK MHQICVLHYD IIWPSGFVCD NCLKKTGRPR
1330 1340 1350 1360 1370 1380
KENKFSAKRL QTTRLGNHLE DRVNKFLRRQ NHPEAGEVFV RVVASSDKTV EVKPGMKSRF
1390 1400 1410 1420 1430 1440
VDSGEMSESF PYRTKALFAF EEIDGVDVCF FGMHVQDTAL IAPHQIQGCV YISYLDSIHF
1450 1460 1470 1480 1490 1500
FRPRCLRTAV YHEILIGYLE YVKKLVYVTA HIWACPPSEG DDYIFHCHPP DQKIPKPKRL
1510 1520 1530 1540 1550 1560
QEWYKKMLDK AFAERIINDY KDIFKQANED RLTSAKELPY FEGDFWPNVL EESIKELEQE
1570 1580 1590 1600 1610 1620
EEERKKEEST AASETPEGSQ GDSKNAKKKN NKKTNKNKSS ISRANKKKPS MPNVSNDLSQ
1630 1640 1650 1660 1670 1680
KLYATMEKHK EVFFVIHLHA GPVISTQPPI VDPDPLLSCD LMDGRDAFLT LARDKHWEFS
1690 1700 1710 1720 1730 1740
SLRRSKWSTL CMLVELHTQG QDRFVYTCNE CKHHVETRWH CTVCEDYDLC INCYNTKSHT
1750 1760 1770 1780 1790 1800
HKMVKWGLGL DDEGSSQGEP QSKSPQESRR LSIQRCIQSL VHACQCRNAN CSLPSCQKMK
1810 1820 1830 1840 1850 1860
RVVQHTKGCK RKTNGGCPVC KQLIALCCYH AKHCQENKCP VPFCLNIKHN VRQQQIQHCL
1870 1880 1890 1900 1910 1920
QQAQLMRRRM ATMNTRNVPQ QSLPSPTSAP PGTPTQQPST PQTPQPPAQP QPSPVNMSPA
1930 1940 1950 1960 1970 1980
GFPNVARTQP PTIVSAGKPT NQVPAPPPPA QPPPAAVEAA RQIEREAQQQ QHLYRANINN
1990 2000 2010 2020 2030 2040
GMPPGRDGMG TPGSQMTPVG LNVPRPNQVS GPVMSSMPPG QWQQAPIPQQ QPMPGMPRPV
2050 2060 2070 2080 2090 2100
MSMQAQAAVA GPRMPNVQPN RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA
2110 2120 2130 2140 2150 2160
FIKQRTAKYV ANQPGMQPQP GLQSQPGMQP QPGMHQQPSL QNLNAMQAGV PRPGVPPPQP
2170 2180 2190 2200 2210 2220
AMGGLNPQGQ ALNIMNPGHN PNMTNMNPQY REMVRRQLLQ HQQQQQQQQQ QQQQQQNSAS
2230 2240 2250 2260 2270 2280
LAGGMAGHSQ FQQPQGPGGY APAMQQQRMQ QHLPIQGSSM GQMAAPMGQL GQMGQPGLGA
2290 2300 2310 2320 2330 2340
DSTPNIQQAL QQRILQQQQM KQQIGSPGQP NPMSPQQHML SGQPQASHLP GQQIATSLSN
2350 2360 2370 2380 2390 2400
QVRSPAPVQS PRPQSQPPHS SPSPRIQPQP SPHHVSPQTG TPHPGLAVTM ASSMDQGHLG
2410 2420 2430 2440
NPEQSAMLPQ LNTPNRSALS SELSLVGDTT GDTLEKFVEG L
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P45481 in FASTA format |
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ExPASy Home page
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