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UniProtKB/Swiss-Prot entry P43773


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HSLU_HAEIN
Primary accession number P43773
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    June 10, 2008 (Entry version 68)
Name and origin of the protein
Protein name ATP-dependent hsl protease ATP-binding subunit hslU
Synonyms None
Gene name
Name: hslU
OrderedLocusNames: HI0497
From
Haemophilus influenzae [TaxID: 727] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).
[2]
X-RAY CRYSTALLOGRAPHY (3.41 ANGSTROMS).
DOI=10.1016/S0092-8674(00)00166-5; PubMed=11106733 [NCBI, ExPASy, EBI, Israel, Japan]
Sousa M.C., Trame C.B., Tsuruta H., Wilbanks S.M., Reddy V.S., McKay D.B.;
"Crystal and solution structures of an HslUV protease-chaperone complex.";
Cell 103:633-643(2000).
[3]
X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
DOI=10.1038/35001629; PubMed=10693812 [NCBI, ExPASy, EBI, Israel, Japan]
Bochtler M., Hartmann C., Song H.K., Bourenkov G.P., Bartunik H.D., Huber R.;
"The structures of HslU and the ATP-dependent protease HslU-HslV.";
Nature 403:800-805(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L42023; AAC22154.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_438655.1; -.
3D structure databases
PDB
1G3I; X-ray; 3.41 A; A/B/C/D/E/F/S/T/U/V/W/X=1-444.[ExPASy / RCSB / EBI]
1G41; X-ray; 2.30 A; A=1-444.[ExPASy / RCSB / EBI]
1IM2; X-ray; 2.80 A; A=1-444.[ExPASy / RCSB / EBI]
1KYI; X-ray; 3.10 A; A/B/C/D/E/F/S/T/U/V/W/X=1-444.[ExPASy / RCSB / EBI]
1OFH; X-ray; 2.50 A; A/B/C=149-444.[ExPASy / RCSB / EBI]
1OFI; X-ray; 3.20 A; A/B/C=149-444.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1G3I; -.
1G41; -.
1IM2; -.
1KYI; -.
1OFH; -.
1OFI; -.
ModBase P43773.
Protein-protein interaction databases
DIP DIP:6175N; -.
IntAct P43773; -.
Enzyme and pathway databases
BioCyc HINF71421:HI_0497-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0009377; Molecular function: HslUV protease activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00249; -; 1.
PBIL [Tree]
InterPro IPR003593; AAA+_ATPase_core.
IPR013093; AAA_2.
IPR004491; HslU.
Graphical view of domain structure.
PANTHER PTHR11262:SF3; HslU; 1.
Pfam PF07724; AAA_2; 2.
Pfam graphical view of domain structure.
SMART SM00382; AAA; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00390; hslU; 1.
BLOCKS P43773.
Genome annotation databases
GeneID 950614; -.
GenomeReviews L42023_GR; HI0497.
KEGG hin:HI0497; -.
NMPDR fig|71421.1.peg.468; -.
TIGR HI0497; -.
Phylogenomic databases
HOGENOM P43773; -.
Other
LinkHub P43773; -.
ProtoNet P43773.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   444  444     ATP-dependent hsl protease ATP-binding subunit hslU. PRO_0000160508
NP_BIND   57    64  8     ATP. 
HELIX   6    14  9      
HELIX   21    39  19      
TURN   42    47  6      
STRAND   53    56  4      
HELIX   63    73  11      
STRAND   78    82  5      
HELIX   83    86  4      
HELIX   97   117  21      
HELIX   228   230  3      
HELIX   237   251  15      
STRAND   253   257  5      
HELIX   259   262  4      
STRAND   269   271  3      
HELIX   272   287  16      
STRAND   290   293  4      
STRAND   296   299  4      
STRAND   304   309  6      
HELIX   316   318  3      
HELIX   321   324  4      
STRAND   329   332  4      
HELIX   338   346  9      
HELIX   352   361  10      
TURN   362   364  3      
STRAND   366   369  4      
HELIX   371   387  17      
HELIX   392   394  3      
HELIX   395   410  16      
HELIX   411   413  3      
STRAND   418   421  4      
HELIX   423   430  8      
TURN   431   435  5      
HELIX   437   443  7      
Sequence information
Length: 444 AA [This is the length of the unprocessed precursor] Molecular weight: 49372 Da [This is the MW of the unprocessed precursor] CRC64: C346EA478E4094CE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSEMTPREIV SELDQHIIGQ ADAKRAVAIA LRNRWRRMQL QEPLRHEVTP KNILMIGPTG 

        70         80         90        100        110        120 
VGKTEIARRL AKLANAPFIK VEATKFTEVG YVGKEVDSII RDLTDSAMKL VRQQEIAKNR 

       130        140        150        160        170        180 
ARAEDVAEER ILDALLPPAK NQWGEVENHD SHSSTRQAFR KKLREGQLDD KEIEIDVSAG 

       190        200        210        220        230        240 
VSMGVEIMAP PGMEEMTNQL QSLFQNLGSD KTKKRKMKIK DALKALIDDE AAKLINPEEL 

       250        260        270        280        290        300 
KQKAIDAVEQ NGIVFIDEID KICKKGEYSG ADVSREGVQR DLLPLVEGST VSTKHGMVKT 

       310        320        330        340        350        360 
DHILFIASGA FQVARPSDLI PELQGRLPIR VELTALSAAD FERILTEPHA SLTEQYKALM 

       370        380        390        400        410        420 
ATEGVNIAFT TDAVKKIAEA AFRVNEKTEN IGARRLHTVM ERLMDKISFS ASDMNGQTVN 

       430        440 
IDAAYVADAL GEVVENEDLS RFIL 

P43773 in FASTA format

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