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UniProtKB/Swiss-Prot entry P43629


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KI3L1_HUMAN
Primary accession number P43629
Secondary accession numbers O43473 Q16541
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 90)
Name and origin of the protein
Protein name Killer cell immunoglobulin-like receptor 3DL1 [Precursor]
Synonyms MHC class I NK cell receptor
Natural killer-associated transcript 3
NKAT-3
p70 natural killer cell receptor clones CL-2/CL-11
HLA-BW4-specific inhibitory NK cell receptor
CD158 antigen-like family member E
CD158e antigen
Gene name
Name: KIR3DL1
Synonyms: CD158E, NKAT3, NKB1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Natural killer cell;
DOI=10.1126/science.7716543; PubMed=7716543 [NCBI, ExPASy, EBI, Israel, Japan]
Colonna M., Samaridis J.;
"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells.";
Science 268:405-408(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Peripheral blood lymphocyte;
DOI=10.1016/1074-7613(95)90069-1; PubMed=8777725 [NCBI, ExPASy, EBI, Israel, Japan]
Wagtmann N., Rajagopalan S., Winter C.C., Peruzzi M., Long E.O.;
"Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer.";
Immunity 3:801-809(1995).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Peripheral blood lymphocyte;
DOI=10.1084/jem.184.2.505; PubMed=8760804 [NCBI, ExPASy, EBI, Israel, Japan]
Pende D., Biassoni R., Cantoni C., Verdiani S., Falco M., di Donato C., Accame L., Bottino C., Moretta A., Moretta L.;
"The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.";
J. Exp. Med. 184:505-518(1996).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Blood;
PubMed=7650366 [NCBI, ExPASy, EBI, Israel, Japan]
D'Andrea A., Chang C., Franz-Bacon K., McClanahan T., Phillips J.H., Lanier L.L.;
"Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.";
J. Immunol. 155:2306-2310(1995).
[5]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS.
DOI=10.1016/S1074-7613(00)80394-5; PubMed=9430221 [NCBI, ExPASy, EBI, Israel, Japan]
Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K., Corliss B., Tyan D., Lanier L.L., Parham P.;
"Human diversity in killer cell inhibitory receptor genes.";
Immunity 7:753-763(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L41269; AAA69870.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U30273; AAB52521.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U30274; AAB52522.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X94262; CAA63938.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U31416; AAC23725.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF022049; AAB95322.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00926776; -.
PIR G01924; G01924.
G01925; G01925.
RefSeq NP_037421.2; -.
UniGene Hs.645228
3D structure databases
HSSP P43628; 1B6U. [HSSP ENTRY / PDB]
SMR P43629; 121-319.
ModBase P43629.
PTM databases
PhosphoSite P43629; -.
Enzyme and pathway databases
Reactome REACT_6900; Signaling in Immune system.
Organism-specific databases
GeneCards GC19P060019; -.
HGNC HGNC:6338; KIR3DL1.
GenAtlas KIR3DL1.
MIM 604946; gene. [NCBI / EBI]
PharmGKB PA30123; -.
Gene expression databases
Bgee P43629; -.
CleanEx HS_KIR3DL1; -.
GermOnline ENSG00000167633; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (non-traceable author statement from UniProtKB).
GO:0030109; Molecular function: HLA-B specific inhibitory MHC class I receptor activity (non-traceable author statement from UniProtKB).
GO:0006955; Biological process: immune response (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR013151; Ig.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 3.
Pfam PF00047; ig; 3.
Pfam graphical view of domain structure.
SMART SM00409; IG; 3.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSG00000167633; Homo sapiens. [Contig view]
GeneID 3811; -.
KEGG hsa:3811; -.
Phylogenomic databases
HOVERGEN P43629; -.
OMA P43629; ESFNMSP.
Other
NextBio 14977; -.
SOURCE KIR3DL1; Homo sapiens.
ProtoNet P43629.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Receptor; Repeat; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    21  21     By similarity. 
CHAIN   22   444  423     Killer cell immunoglobulin-like receptor 3DL1. PRO_0000015087
TOPO_DOM   22   340  319     Extracellular (Potential). 
TRANSMEM   341   360  20     Potential. 
TOPO_DOM   361   444  84     Cytoplasmic (Potential). 
DOMAIN   42   102  61     Ig-like C2-type 1. 
DOMAIN   137   202  66     Ig-like C2-type 2. 
DOMAIN   237   300  64     Ig-like C2-type 3. 
CARBOHYD   92    92        N-linked (GlcNAc...) (Potential). 
CARBOHYD   179   179        N-linked (GlcNAc...) (Potential). 
CARBOHYD   273   273        N-linked (GlcNAc...) (Potential). 
DISULFID   49    95        By similarity. 
DISULFID   144   195        By similarity. 
DISULFID   244   293        By similarity. 
VARIANT   2     2  1     S -> L (in dbSNP:rs605219 [NCBI]). VAR_010319 
VARIANT   13    13  1     L -> F. VAR_010320 
VARIANT   23    23  1     M -> V. VAR_010321 
VARIANT   68    68  1     I -> V (in dbSNP:rs45556431 [NCBI]). VAR_010322 
VARIANT   75    75  1     I -> L (in dbSNP:rs1049150 [NCBI]). VAR_010323 
VARIANT   203   203  1     P -> S (in dbSNP:rs2273731 [NCBI]). VAR_049987 [3D]
VARIANT   220   220  1     P -> L (in dbSNP:rs680891 [NCBI]). VAR_049988 [3D]
VARIANT   259   259  1     G -> R (in dbSNP:rs1049215 [NCBI]). VAR_010336 [3D]
VARIANT   333   333  1     S -> C. VAR_010324 
VARIANT   362   362  1     L -> R (in dbSNP:rs1130468 [NCBI]). VAR_049989 
VARIANT   394   394  1     E -> Q (in dbSNP:rs1130513 [NCBI]). VAR_049990 
Sequence information
Length: 444 AA [This is the length of the unprocessed precursor] Molecular weight: 49098 Da [This is the MW of the unprocessed precursor] CRC64: 47DEA12BBAFDEC53 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML 

        70         80         90        100        110        120 
YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPVVIMVTGN 

       130        140        150        160        170        180 
HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF 

       190        200        210        220        230        240 
SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV 

       250        260        270        280        290        300 
TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS 

       310        320        330        340        350        360 
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII LFILLLFFLL 

       370        380        390        400        410        420 
HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ LDHCVFTQRK ITRPSQRPKT 

       430        440 
PPTDTILYTE LPNAKPRSKV VSCP 

P43629 in FASTA format

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