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UniProtKB/Swiss-Prot entry P43291


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SRK2A_ARATH
Primary accession number P43291
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 75)
Name and origin of the protein
Protein name Serine/threonine-protein kinase SRK2A
Synonyms EC 2.7.11.1
Arabidopsis protein SK1
OST1-kinase-like 7
SNF1-related kinase 2.4
SnRK2.4
Gene name
Name: SRK2A
Synonyms: ASK1, OSKL7, SNRK2.4
OrderedLocusNames: At1g10940
ORFNames: T19D16.14
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Columbia;
TISSUE=Leaf;
DOI=10.1007/BF00047402; PubMed=8393717 [NCBI, ExPASy, EBI, Israel, Japan]
Park Y.S., Hong S.W., Oh S.A., Kwak J.M., Lee H.H., Nam H.G.;
"Two putative protein kinases from Arabidopsis thaliana contain highly acidic domains.";
Plant Mol. Biol. 22:615-624(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/35048500; PubMed=11130712 [NCBI, ExPASy, EBI, Israel, Japan]
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
Nature 408:816-820(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[5]
GENE FAMILY, AND NOMENCLATURE.
DOI=10.1104/pp.102.011999; PubMed=12805596 [NCBI, ExPASy, EBI, Israel, Japan]
Hrabak E.M., Chan C.W.M., Gribskov M., Harper J.F., Choi J.H., Halford N., Kudla J., Luan S., Nimmo H.G., Sussman M.R., Thomas M., Walker-Simmons K., Zhu J.-K., Harmon A.C.;
"The Arabidopsis CDPK-SnRK superfamily of protein kinases.";
Plant Physiol. 132:666-680(2003).
[6]
TISSUE SPECIFICITY, AND INDUCTION.
DOI=10.1074/jbc.M405259200; PubMed=15292193 [NCBI, ExPASy, EBI, Israel, Japan]
Boudsocq M., Barbier-Brygoo H., Lauriere C.;
"Identification of nine sucrose nonfermenting 1-related protein kinases 2 activated by hyperosmotic and saline stresses in Arabidopsis thaliana.";
J. Biol. Chem. 279:41758-41766(2004).
[7]
GENE FAMILY.
DOI=10.1074/jbc.M509820200; PubMed=16365038 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshida R., Umezawa T., Mizoguchi T., Takahashi S., Takahashi F., Shinozaki K.;
"The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis.";
J. Biol. Chem. 281:5310-5318(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M91548; AAA02840.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U95973; AAB65483.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY093130; AAM13129.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT008850; AAP68289.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY084221; AAM60822.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S36944; S36944.
RefSeq NP_172563.1; -.
UniGene At.23750
3D structure databases
HSSP P31751; 1GZK. [HSSP ENTRY / PDB]
ModBase P43291.
Protein-protein interaction databases
IntAct P43291; -.
Organism-specific databases
TAIR At1g10940; -.
Gene expression databases
ArrayExpress P43291; -.
GermOnline AT1G10940; Arabidopsis thaliana.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR015740; S/T_plantPK.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.
PANTHER PTHR22982:SF58; S/T_plantPK; 1.
Pfam PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00220; S_TKc; 1.
SMART graphical view of domain structure.
PROSITE PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P43291.
Proteomic databases
ProMEX P43291; -.
Genome annotation databases
GeneID 837637; -.
GenomeReviews CT485782_GR; AT1G10940.
KEGG ath:AT1G10940; -.
NMPDR fig|3702.1.peg.1343; -.
Other
ProtoNet P43291.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Serine/threonine-protein kinase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   363  363     Serine/threonine-protein kinase SRK2A. PRO_0000085636
DOMAIN   4   260  257     Protein kinase. 
NP_BIND   10    18  9     ATP (By similarity). 
COMPBIAS   319   348  30     Asp/Glu-rich (acidic). 
ACT_SITE   123   123        Proton acceptor (By similarity). 
BINDING   33    33        ATP (By similarity). 
MOD_RES   149   149        Phosphoserine (By similarity). 
MOD_RES   150   150        Phosphoserine (By similarity). 
MOD_RES   154   154        Phosphoserine (By similarity). 
MOD_RES   158   158        Phosphoserine (By similarity). 
MOD_RES   159   159        Phosphothreonine (By similarity). 
Sequence information
Length: 363 AA [This is the length of the unprocessed precursor] Molecular weight: 41169 Da [This is the MW of the unprocessed precursor] CRC64: 89C31C87AB6C6E78 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDKYELVKDI GAGNFGVARL MKVKNSKELV AMKYIERGPK IDENVAREII NHRSLRHPNI 

        70         80         90        100        110        120 
IRFKEVVLTP THLAIAMEYA AGGELFERIC SAGRFSEDEA RYFFQQLISG VSYCHAMQIC 

       130        140        150        160        170        180 
HRDLKLENTL LDGSPAPRLK ICDFGYSKSS LLHSRPKSTV GTPAYIAPEV LSRREYDGKM 

       190        200        210        220        230        240 
ADVWSCGVTL YVMLVGAYPF EDQEDPKNFR KTIQKIMAVQ YKIPDYVHIS QDCKNLLSRI 

       250        260        270        280        290        300 
FVANSLKRIT IAEIKKHSWF LKNLPRELTE TAQAAYFKKE NPTFSLQTVE EIMKIVADAK 

       310        320        330        340        350        360 
TPPPVSRSIG GFGWGGNGDA DGKEEDAEDV EEEEEEVEEE EDDEDEYDKT VKEVHASGEV 


RIS 

P43291 in FASTA format

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View entry in raw text format (no links)
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