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UniProtKB/Swiss-Prot entry P43268


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ETV4_HUMAN
Primary accession number P43268
Secondary accession numbers A8K314 Q96AW9
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on April 12, 2005 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 71)
Name and origin of the protein
Protein name ETS translocation variant 4
Synonyms Adenovirus E1A enhancer-binding protein
E1A-F
Gene name
Name: ETV4
Synonyms: E1AF
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0888-7543(95)80133-7; PubMed=7774926 [NCBI, ExPASy, EBI, Israel, Japan]
Friedman L.S., Ostermeyer E.A., Lynch E.D., Szabo C.I., Meza J.E., Anderson L.A., Dowd P., Lee M.K., Rowell S.E., Ellison J., Boyd J., King M.-C.;
"22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.";
Genomics 25:256-263(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/S0378-1119(99)00400-X; PubMed=10564827 [NCBI, ExPASy, EBI, Israel, Japan]
Coutte L., Monte D., Baert J.-L., de Launoit Y.;
"Genomic organization of the human e1af gene, a member of Ets transcription factors.";
Gene 240:201-207(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 23-484.
DOI=10.1093/nar/21.3.547; PubMed=8441666 [NCBI, ExPASy, EBI, Israel, Japan]
Higashino F., Yoshida K., Fujinaga K., Kamio K., Fujinaga K.;
"Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family.";
Nucleic Acids Res. 21:547-553(1993).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140 AND SER-149, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U18018; AAA95991.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF095890; AAD09186.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF095887; AAD09186.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF095888; AAD09186.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF095889; AAD09186.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK290429; BAF83118.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC016623; AAH16623.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D12765; BAA02234.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00017382; -.
PIR S35534; S35534.
RefSeq NP_001073143.1; -.
NP_001977.1; -.
UniGene Hs.434059
3D structure databases
HSSP P28324; 1BC8. [HSSP ENTRY / PDB]
ModBase P43268.
PTM databases
PhosphoSite P43268; -.
Organism-specific databases
GeneCards GC17M038960; -.
H-InvDB HIX0019239; -.
HGNC HGNC:3493; ETV4.
GenAtlas ETV4.
HPA HPA005768; -.
MIM 600711; gene. [NCBI / EBI]
PharmGKB PA27907; -.
Gene expression databases
ArrayExpress P43268; -.
Bgee P43268; -.
CleanEx HS_ETV4; -.
GermOnline ENSG00000175832; Homo sapiens.
Ontologies
GO
GO:0005730; Cellular component: nucleolus (inferred from direct assay from HPA).
GO:0043565; Molecular function: sequence-specific DNA binding (inferred from electronic annotation from InterPro).
GO:0016563; Molecular function: transcription activator activity (non-traceable author statement from UniProtKB).
GO:0003700; Molecular function: transcription factor activity (inferred from electronic annotation from InterPro).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (non-traceable author statement from UniProtKB).
GO:0006350; Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000418; Ets.
IPR006715; ETS_PEA3_N.
IPR011991; Wing_hlx_DNA_bd.
Graphical view of domain structure.
Gene3D G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
Pfam PF00178; Ets; 1.
PF04621; ETS_PEA3_N; 1.
Pfam graphical view of domain structure.
PRINTS PR00454; ETSDOMAIN.
SMART SM00413; ETS; 1.
SMART graphical view of domain structure.
PROSITE PS00345; ETS_DOMAIN_1; 1.
PS00346; ETS_DOMAIN_2; 1.
PS50061; ETS_DOMAIN_3; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P43268; -.
Genome annotation databases
Ensembl ENSG00000175832; Homo sapiens. [Contig view]
GeneID 2118; -.
KEGG hsa:2118; -.
Phylogenomic databases
HOGENOM P43268; -.
HOVERGEN P43268; -.
OMA P43268; PFPRAEQ.
Other
NextBio 8559; -.
SOURCE ETV4; Homo sapiens.
ProtoNet P43268.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Activator; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   484  484     ETS translocation variant 4. PRO_0000204116
DNA_BIND   341   421  81     ETS. 
COMPBIAS   49    75  27     Asp/Glu-rich (acidic). 
COMPBIAS   148   244  97     Gln-rich. 
MOD_RES   140   140        Phosphoserine. 
MOD_RES   149   149        Phosphoserine. 
VARIANT   437   437  1     R -> C (in dbSNP:rs34260468 [NCBI]). VAR_048950 
CONFLICT   24    27        GNGS -> EMSD (in Ref. 5). 
Sequence information
Length: 484 AA [This is the length of the unprocessed precursor] Molecular weight: 53938 Da [This is the MW of the unprocessed precursor] CRC64: BA9864F3C690A8C1 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MERRMKAGYL DQQVPYTFSS KSPGNGSLRE ALIGPLGKLM DPGSLPPLDS EDLFQDLSHF 

        70         80         90        100        110        120 
QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ SPRTDPALSC SRKPPLPYHH 

       130        140        150        160        170        180 
GEQCLYSSAY DPPRQIAIKS PAPGALGQSP LQPFPRAEQR NFLRSSGTSQ PHPGHGYLGE 

       190        200        210        220        230        240 
HSSVFQQPLD ICHSFTSQGG GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH DPLYEQAGQP 

       250        260        270        280        290        300 
AVDQGGVNGH RYPGAGVVIK QEQTDFAYDS DVTGCASMYL HTEGFSGPSP GDGAMGYGYE 

       310        320        330        340        350        360 
KPLRPFPDDV CVVPEKFEGD IKQEGVGAFR EGPPYQRRGA LQLWQFLVAL LDDPTNAHFI 

       370        380        390        400        410        420 
AWTGRGMEFK LIEPEEVARL WGIQKNRPAM NYDKLSRSLR YYYEKGIMQK VAGERYVYKF 

       430        440        450        460        470        480 
VCEPEALFSL AFPDNQRPAL KAEFDRPVSE EDTVPLSHLD ESPAYLPELA GPAQPFGPKG 


GYSY 

P43268 in FASTA format

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