[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Blood;
DOI=10.1016/0014-5793(94)01349-6; PubMed=7805878 [NCBI, ExPASy, EBI, Israel, Japan]
Shi G.-P.,
Chapman H.A.,
Bhairi S.M.,
Deleeuw C.,
Reddy V.Y.,
Weiss S.J.;
"Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.";
FEBS Lett. 357:129-134(1995).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Bone;
DOI=10.1006/bbrc.1995.1013; PubMed=7818555 [NCBI, ExPASy, EBI, Israel, Japan]
Inaoka T.,
Bilbe G.,
Ishibashi O.,
Tezuka K.,
Kumegawa M.,
Kokubo T.;
"Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.";
Biochem. Biophys. Res. Commun. 206:89-96(1995).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Osteoclastoma;
PubMed=8585423 [NCBI, ExPASy, EBI, Israel, Japan]
Li Y.,
Alexander M.,
Wucherpfennig A.L.,
Yelick P.,
Chen W.,
Stashenko P.;
"Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas.";
J. Bone Miner. Res. 10:1197-1202(1995).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Spleen;
PubMed=7576232 [NCBI, ExPASy, EBI, Israel, Japan]
Broemme D.,
Okamoto K.;
"Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution.";
Biol. Chem. Hoppe-Seyler 376:379-384(1995).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
DOI=10.1038/nsb0297-105; PubMed=9033587 [NCBI, ExPASy, EBI, Israel, Japan]
McGrath M.E.,
Klaus J.L.,
Barnes M.G.,
Bromme D.;
"Crystal structure of human cathepsin K complexed with a potent inhibitor.";
Nat. Struct. Biol. 4:105-109(1997).
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[7]
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X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
DOI=10.1073/pnas.94.26.14249; PubMed=9405598 [NCBI, ExPASy, EBI, Israel, Japan]
Thompson S.K.,
Halbert S.M.,
Bossard M.J.,
Tomaszek T.A.,
Levy M.A.,
Zhao B.,
Smith W.W.,
Abdel-Meguid S.S.,
Janson C.A.,
D'Alessio K.J.,
McQueney M.S.,
Amegadzie B.Y.,
Hanning C.R.,
Desjarlais R.L.,
Briand J.,
Sarkar S.K.,
Huddleston M.J.,
Ijames C.F.,
Carr S.A., ![]()
Garnes K.T.,
Shu A.,
Heys J.R.,
Bradbeer J.,
Zembryki D.,
Veber D.F.;
"Design of potent and selective human cathepsin K inhibitors that span the active site.";
Proc. Natl. Acad. Sci. U.S.A. 94:14249-14254(1997).
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[8]
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X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF ZYMOGEN FORM.
DOI=10.1021/bi9822271; PubMed=9893980 [NCBI, ExPASy, EBI, Israel, Japan]
LaLonde J.M.,
Zhao B.,
Janson C.A.,
D'Alessio K.J.,
McQueney M.S.,
Orsini M.J.,
Debouck C.M.,
Smith W.W.;
"The crystal structure of human procathepsin K.";
Biochemistry 38:862-869(1999).
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[9]
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X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS).
PubMed=10048321 [NCBI, ExPASy, EBI, Israel, Japan]
Sivaraman J.,
Lalumiere M.,
Menard R.,
Cygler M.;
"Crystal structure of wild-type human procathepsin K.";
Protein Sci. 8:283-290(1999).
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[10]
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VARIANT PKND ARG-146.
PubMed=8703060 [NCBI, ExPASy, EBI, Israel, Japan]
Gelb B.D.,
Shi G.-P.,
Chapman H.A.,
Desnick R.J.;
"Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.";
Science 273:1236-1238(1996).
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[11]
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VARIANT PKND VAL-277.
DOI=10.1086/301795; PubMed=9529353 [NCBI, ExPASy, EBI, Israel, Japan]
Gelb B.D.,
Willner J.P.,
Dunn T.M.,
Kardon N.B.,
Verloes A.,
Poncin J.,
Desnick R.J.;
"Paternal uniparental disomy for chromosome 1 revealed by molecular analysis of a patient with pycnodysostosis.";
Am. J. Hum. Genet. 62:848-854(1998).
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[12]
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VARIANT PKND GLU-79.
PubMed=10491211 [NCBI, ExPASy, EBI, Israel, Japan]
Ho N.,
Punturieri A.,
Wilkin D.,
Szabo J.,
Johnson M.,
Whaley J.,
Davis J.,
Clark A.,
Weiss S.,
Francomano C.;
"Mutations of CTSK result in pycnodysostosis via a reduction in cathepsin K protein.";
J. Bone Miner. Res. 14:1649-1653(1999).
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[13]
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VARIANTS PKND GLU-79 AND PRO-309.
DOI=10.1038/sj.ejhg.5200481; PubMed=10878663 [NCBI, ExPASy, EBI, Israel, Japan]
Haagerup A.,
Hertz J.M.,
Christensen M.F.,
Binderup H.,
Kruse T.A.;
"Cathepsin K gene mutations and 1q21 haplotypes in at patients with pycnodysostosis in an outbred population.";
Eur. J. Hum. Genet. 8:431-436(2000).
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