[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1038/369756a0; PubMed=8008069 [NCBI, ExPASy, EBI, Israel, Japan]
Brown E.J.,
Albers M.W.,
Shin T.B.,
Ichikawa K.,
Keith C.T.,
Lane W.S.,
Schreiber S.L.;
"A mammalian protein targeted by G1-arresting rapamycin-receptor complex.";
Nature 369:756-758(1994).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/geno.1997.5186; PubMed=9653645 [NCBI, ExPASy, EBI, Israel, Japan]
Onyango P.,
Lubyova B.,
Gardellin P.,
Kurzbauer R.,
Weith A.;
"Molecular cloning and expression analysis of five novel genes in chromosome 1p36.";
Genomics 50:187-198(1998).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G.,
Barlow K.F.,
McLay K.E.,
Kaul R.,
Swarbreck D.,
Dunham A.,
Scott C.E.,
Howe K.L.,
Woodfine K.,
Spencer C.C.A.,
Jones M.C.,
Gillson C.,
Searle S.,
Zhou Y.,
Kokocinski F.,
McDonald L.,
Evans R.,
Phillips K.,
Atkinson A., ![]()
Cooper R.,
Jones C.,
Hall R.E.,
Andrews T.D.,
Lloyd C.,
Ainscough R.,
Almeida J.P.,
Ambrose K.D.,
Anderson F.,
Andrew R.W.,
Ashwell R.I.S.,
Aubin K.,
Babbage A.K.,
Bagguley C.L.,
Bailey J.,
Beasley H.,
Bethel G.,
Bird C.P.,
Bray-Allen S.,
Brown J.Y.,
Brown A.J.,
Buckley D.,
Burton J.,
Bye J.,
Carder C.,
Chapman J.C.,
Clark S.Y.,
Clarke G.,
Clee C.,
Cobley V.,
Collier R.E.,
Corby N.,
Coville G.J.,
Davies J.,
Deadman R.,
Dunn M.,
Earthrowl M.,
Ellington A.G.,
Errington H.,
Frankish A.,
Frankland J.,
French L.,
Garner P.,
Garnett J.,
Gay L.,
Ghori M.R.J.,
Gibson R.,
Gilby L.M.,
Gillett W.,
Glithero R.J.,
Grafham D.V.,
Griffiths C.,
Griffiths-Jones S.,
Grocock R.,
Hammond S.,
Harrison E.S.I.,
Hart E.,
Haugen E.,
Heath P.D.,
Holmes S.,
Holt K.,
Howden P.J.,
Hunt A.R.,
Hunt S.E.,
Hunter G.,
Isherwood J.,
James R.,
Johnson C.,
Johnson D.,
Joy A.,
Kay M.,
Kershaw J.K.,
Kibukawa M.,
Kimberley A.M.,
King A.,
Knights A.J.,
Lad H.,
Laird G.,
Lawlor S.,
Leongamornlert D.A.,
Lloyd D.M.,
Loveland J.,
Lovell J.,
Lush M.J.,
Lyne R.,
Martin S.,
Mashreghi-Mohammadi M.,
Matthews L.,
Matthews N.S.W.,
McLaren S.,
Milne S.,
Mistry S.,
Moore M.J.F.,
Nickerson T.,
O'Dell C.N.,
Oliver K.,
Palmeiri A.,
Palmer S.A.,
Parker A.,
Patel D.,
Pearce A.V.,
Peck A.I.,
Pelan S.,
Phelps K.,
Phillimore B.J.,
Plumb R.,
Rajan J.,
Raymond C.,
Rouse G.,
Saenphimmachak C.,
Sehra H.K.,
Sheridan E.,
Shownkeen R.,
Sims S.,
Skuce C.D.,
Smith M.,
Steward C.,
Subramanian S.,
Sycamore N.,
Tracey A.,
Tromans A.,
Van Helmond Z.,
Wall M.,
Wallis J.M.,
White S.,
Whitehead S.L.,
Wilkinson J.E.,
Willey D.L.,
Williams H.,
Wilming L.,
Wray P.W.,
Wu Z.,
Coulson A.,
Vaudin M.,
Sulston J.E.,
Durbin R.M.,
Hubbard T.,
Wooster R.,
Dunham I.,
Carter N.P.,
McVean G.,
Ross M.T.,
Harrow J.,
Olson M.V.,
Beck S.,
Rogers J.,
Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cerebellum;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1362-2549.
DOI=10.1038/sj.gene.6363745; PubMed=11426320 [NCBI, ExPASy, EBI, Israel, Japan]
Stover C.,
Endo Y.,
Takahashi M.,
Lynch N.,
Constantinescu C.,
Vorup-Jensen T.,
Thiel S.,
Friedl H.,
Hankeln T.,
Hall R.,
Gregory S.,
Fujita T.,
Schwaeble W.;
"The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.";
Genes Immun. 2:119-127(2001).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1987-2146, AND TISSUE SPECIFICITY.
TISSUE=B-cell;
DOI=10.1073/pnas.91.26.12574; PubMed=7809080 [NCBI, ExPASy, EBI, Israel, Japan]
Chiu M.I.,
Katz H.,
Berlin V.;
"RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.";
Proc. Natl. Acad. Sci. U.S.A. 91:12574-12578(1994).
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[7]
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INTERACTION WITH UBQLN1.
DOI=10.1016/S0167-4889(01)00164-1; PubMed=11853878 [NCBI, ExPASy, EBI, Israel, Japan]
Wu S.,
Mikhailov A.,
Kallo-Hosein H.,
Hara K.,
Yonezawa K.,
Avruch J.;
"Characterization of ubiquilin 1, an mTOR-interacting protein.";
Biochim. Biophys. Acta 1542:41-56(2002).
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[8]
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FUNCTION, IDENTIFICATION IN TORC2 COMPLEX, AND INTERACTION WITH RICTOR.
DOI=10.1016/j.cub.2004.06.054; PubMed=15268862 [NCBI, ExPASy, EBI, Israel, Japan]
Sarbassov D.D.,
Ali S.M.,
Kim D.-H.,
Guertin D.A.,
Latek R.R.,
Erdjument-Bromage H.,
Tempst P.,
Sabatini D.M.;
"Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.";
Curr. Biol. 14:1296-1302(2004).
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[9]
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FUNCTION.
DOI=10.1126/science.1106148; PubMed=15718470 [NCBI, ExPASy, EBI, Israel, Japan]
Sarbassov D.D.,
Guertin D.A.,
Ali S.M.,
Sabatini D.M.;
"Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.";
Science 307:1098-1101(2005).
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[10]
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IDENTIFICATION IN TORC2 COMPLEX, AND INTERACTION WITH PRR5.
DOI=10.1074/jbc.M704343200; PubMed=17599906 [NCBI, ExPASy, EBI, Israel, Japan]
Woo S.-Y.,
Kim D.-H.,
Jun C.-B.,
Kim Y.-M.,
Haar E.V.,
Lee S.-I.,
Hegg J.W.,
Bandhakavi S.,
Griffin T.J.,
Kim D.-H.;
"PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.";
J. Biol. Chem. 282:25604-25612(2007).
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[11]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1162, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K.,
Sugiyama N.,
Kyono Y.,
Tomita M.,
Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
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[12]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567 AND SER-1261, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H.,
Olsen J.V.,
Bairlein M.,
Gnad F.,
Oppermann F.S.,
Korner R.,
Greff Z.,
Keri G.,
Stemmann O.,
Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
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[13]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2478 AND SER-2481, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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[14]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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[15]
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X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 2018-2112.
DOI=10.1126/science.273.5272.239; PubMed=8662507 [NCBI, ExPASy, EBI, Israel, Japan]
Choi J.,
Chen J.,
Schreiber S.L.,
Clardy J.;
"Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.";
Science 273:239-242(1996).
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[16]
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X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 2018-2112.
DOI=10.1107/S0907444998014747; PubMed=10089303 [NCBI, ExPASy, EBI, Israel, Japan]
Liang J.,
Choi J.,
Clardy J.;
"Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.";
Acta Crystallogr. D 55:736-744(1999).
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[17]
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VARIANTS [LARGE SCALE ANALYSIS] SER-8; THR-135; VAL-1083; VAL-1134; PHE-1178; VAL-2011; TYR-2215 AND LEU-2476.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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