[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT TYR-561. TISSUE=Placenta; DOI=10.1016/0092-8674(94)90235-6; PubMed=7512451 [NCBI, ExPASy, EBI, Israel, Japan] Akira S., Nishio Y., Inoue M., Wang X.-J., Wei S., Matsusaka T., Yoshida K., Sudo T., Naruto M., Kishimoto T.; "Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway."; Cell 77:63-71(1994).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). DOI=10.1016/S0378-1119(98)00185-1; PubMed=9630560 [NCBI, ExPASy, EBI, Israel, Japan] Della Pietra L., Bressan A., Pezzotti A., Serlupi-Crescenzi O.; "Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence."; Gene 213:119-124(1998).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-143. SeattleSNPs variation discovery resource; Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND DEL-701). TISSUE=Kidney, and Pancreas; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[5]	NUCLEOTIDE SEQUENCE [MRNA] OF 564-704. TISSUE=Liver; Della Pietra L., Bressan A., Pezzotti A.R., Serlupi-Crescenzi O.; Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
[6]	PHOSPHORYLATION AT SERINE RESIDUES. DOI=10.1126/science.7701321; PubMed=7701321 [NCBI, ExPASy, EBI, Israel, Japan] Zhang X., Blenis J., Li H.-C., Schindler C., Chen-Kiang S.; "Requirement of serine phosphorylation for formation of STAT-promoter complexes."; Science 267:1990-1994(1995).
[7]	INTERACTION WITH NCOA1. DOI=10.1074/jbc.M111486200; PubMed=11773079 [NCBI, ExPASy, EBI, Israel, Japan] Giraud S., Bienvenu F., Avril S., Gascan H., Heery D.M., Coqueret O.; "Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a."; J. Biol. Chem. 277:8004-8011(2002).
[8]	INTERACTION WITH HCV CORE PROTEIN. DOI=10.1084/jem.20012127; PubMed=12208879 [NCBI, ExPASy, EBI, Israel, Japan] Yoshida T., Hanada T., Tokuhisa T., Kosai K., Sata M., Kohara M., Yoshimura A.; "Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation."; J. Exp. Med. 196:641-653(2002).
[9]	INTERACTION WITH IL23R. PubMed=12023369 [NCBI, ExPASy, EBI, Israel, Japan] Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M., Kastelein R.A., de Waal Malefyt R., Moore K.W.; "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."; J. Immunol. 168:5699-5708(2002).
[10]	FUNCTION, AND INTERACTION WITH IL31RA. DOI=10.1074/jbc.M401122200; PubMed=15194700 [NCBI, ExPASy, EBI, Israel, Japan] Dreuw A., Radtke S., Pflanz S., Lippok B.E., Heinrich P.C., Hermanns H.M.; "Characterization of the signaling capacities of the novel gp130-like cytokine receptor."; J. Biol. Chem. 279:36112-36120(2004).
[11]	INTERACTION WITH TMF1. DOI=10.1038/sj.onc.1208149; PubMed=15467733 [NCBI, ExPASy, EBI, Israel, Japan] Perry E., Tsruya R., Levitsky P., Pomp O., Taller M., Weisberg S., Parris W., Kulkarni S., Malovani H., Pawson T., Shpungin S., Nir U.; "TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3."; Oncogene 23:8908-8919(2004).
[12]	INTERACTION WITH PELP1. DOI=10.1158/0008-5472.CAN-04-4664; PubMed=15994929 [NCBI, ExPASy, EBI, Israel, Japan] Manavathi B., Nair S.S., Wang R.-A., Kumar R., Vadlamudi R.K.; "Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation."; Cancer Res. 65:5571-5577(2005).
[13]	INTERACTION WITH SOCS7. DOI=10.1074/jbc.M411596200; PubMed=15677474 [NCBI, ExPASy, EBI, Israel, Japan] Martens N., Uzan G., Wery M., Hooghe R., Hooghe-Peters E.L., Gertler A.; "Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation."; J. Biol. Chem. 280:13817-13823(2005).
[14]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-705, AND MASS SPECTROMETRY. TISSUE=Epithelium; DOI=10.1074/mcp.M500089-MCP200; PubMed=15951569 [NCBI, ExPASy, EBI, Israel, Japan] Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J., Lauffenburger D.A., White F.M.; "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules."; Mol. Cell. Proteomics 4:1240-1250(2005).
[15]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-705, AND MASS SPECTROMETRY. DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan] Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.; "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."; Nat. Biotechnol. 23:94-101(2005).
[16]	SUBCELLULAR LOCATION. DOI=10.1073/pnas.0501643102; PubMed=15919823 [NCBI, ExPASy, EBI, Israel, Japan] Liu L., McBride K.M., Reich N.C.; "STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3."; Proc. Natl. Acad. Sci. U.S.A. 102:8150-8155(2005).
[17]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-705, AND MASS SPECTROMETRY. DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan] Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer."; Cell 131:1190-1203(2007).
[18]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-691, AND MASS SPECTROMETRY. DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan] Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."; Science 316:1160-1166(2007).
[19]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-714 AND SER-727, AND MASS SPECTROMETRY. DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan] Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.; "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."; Mol. Cell 31:438-448(2008).
[20]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-714 AND SER-727, AND MASS SPECTROMETRY. DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan] Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.; "A quantitative atlas of mitotic phosphorylation."; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[21]	IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY. Colinge J., Superti-Furga G., Bennett K.L.; Submitted (OCT-2008) to UniProtKB.
[22]	VARIANTS AD-HIES GLN-382; LEU-382; TRP-382; LEU-384; SER-384; GLN-423; VAL-463 DEL; ASN-611; VAL-621; ILE-622; LEU-637; MET-637; GLN-644 DEL AND CYS-657. DOI=10.1056/NEJMoa073687; PubMed=17881745 [NCBI, ExPASy, EBI, Israel, Japan] Holland S.M., DeLeo F.R., Elloumi H.Z., Hsu A.P., Uzel G., Brodsky N., Freeman A.F., Demidowich A., Davis J., Turner M.L., Anderson V.L., Darnell D.N., Welch P.A., Kuhns D.B., Frucht D.M., Malech H.L., Gallin J.I., Kobayashi S.D., Whitney A.R., Voyich J.M., Musser J.M., Woellner C., Schaffer A.A., Puck J.M., Grimbacher B.; "STAT3 mutations in the hyper-IgE syndrome."; N. Engl. J. Med. 357:1608-1619(2007).
[23]	VARIANTS AD-HIES GLN-382; TRP-382; ILE-389; TYR-437 AND VAL-463 DEL, AND CHARACTERIZATION OF VARIANTS AD-HIES GLN-382; TRP-382; ILE-389; TYR-437 AND VAL-463 DEL. DOI=10.1038/nature06096; PubMed=17676033 [NCBI, ExPASy, EBI, Israel, Japan] Minegishi Y., Saito M., Tsuchiya S., Tsuge I., Takada H., Hara T., Kawamura N., Ariga T., Pasic S., Stojkovic O., Metin A., Karasuyama H.; "Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome."; Nature 448:1058-1062(2007).

Comments

FUNCTION: Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
SUBUNIT: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOA1, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA. Interacts with SIPAR. Interacts (via SH2 domain) with NLK (By similarity). Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import (By similarity). Interacts with TMF1.
INTERACTION:
Q9UER7:DAXX; NbExp=2; IntAct=EBI-518675, EBI-77321;
Q07666:KHDRBS1; NbExp=1; IntAct=EBI-518675, EBI-1364;
O43318:MAP3K7; NbExp=1; IntAct=EBI-518675, EBI-358684;
Q13287:NMI; NbExp=1; IntAct=EBI-518675, EBI-372942;
Q9Y5S9:RBM8A; NbExp=2; IntAct=EBI-518675, EBI-447231;
P52630:STAT2; NbExp=1; IntAct=EBI-518675, EBI-1546963;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation.
ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name 1

Isoform ID P40763-1

This is the isoform sequence displayed in this entry.

Name Del-701

Isoform ID P40763-2

Features which should be applied to build the isoform sequence: VSP_010474.
TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
PTM: Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity.
DISEASE: Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.
MISCELLANEOUS: Involved in the gp130-mediated signaling pathway.
SIMILARITY: Belongs to the transcription factor STAT family.
SIMILARITY: Contains 1 SH2 domain.
WEB RESOURCE: Name=Wikipedia; Note=STAT3 entry; URL="http://en.wikipedia.org/wiki/STAT3";.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/STAT3ID444.html";.
WEB RESOURCE: Name=STAT3base; Note=STAT3 mutation db; URL="http://bioinf.uta.fi/STAT3base/";.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/stat3/";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L29277; AAA58374.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ012463; CAA10032.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY572796; AAS66986.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000627; AAH00627.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014482; AAH14482.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF029311; AAB84254.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00306436; -.
IPI00784414; -.

PIR

A54444; A54444.

RefSeq

NP_003141.2; -.
NP_644805.1; -.
NP_998827.1; -.

UniGene

Hs.463059

3D structure databases

HSSP

P42227; 1BG1. [HSSP ENTRY / PDB]

SMR

P40763; 136-703.

ModBase

P40763.

Protein-protein interaction databases

IntAct

P40763; 12.

PTM databases

PhosphoSite

P40763; -.

Enzyme and pathway databases

Pathway_Interaction_DB

ifngpathway; IFN-gamma pathway.
il12_stat4pathway; IL12 signaling mediated by STAT4.
il12_2pathway; IL12-mediated signaling events.
il2_1pathway; IL2-mediated signaling events.
il23pathway; IL23-mediated signaling events.
il27pathway; IL27-mediated signaling events.
il6_7pathway; IL6-mediated signaling events.
trkrpathway; Neurotrophic factor-mediated Trk receptor signaling.
pdgfrbpathway; PDGFR-beta signaling pathway.
met_pathway; Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met).
hdac_classi_pathway; Signaling events mediated by HDAC Class I.
ptp1bpathway; Signaling events mediated by PTP1B.
kitpathway; Signaling events mediated by Stem cell factor receptor (c-Kit).

Reactome

REACT_11061; Signalling by NGF.

Organism-specific databases

GC17M037718; -.

HIX0013840; -.

HGNC:11364; STAT3.

CAB003859; -.
HPA001671; -.

MIM

102582; gene. [NCBI / EBI]
147060; phenotype. [NCBI / EBI]

Orphanet

2314; Autosomal dominant hyper IgE syndrome.

PharmGKB

PA337; -.

Gene expression databases

P40763; -.

P40763; -.

HS_STAT3; -.

ENSG00000168610; Homo sapiens.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from direct assay from HPA).
GO:0005634;	Cellular component: nucleus (inferred from direct assay from HGNC).
GO:0005509;	Molecular function: calcium ion binding (inferred from electronic annotation from InterPro).
GO:0005062;	Molecular function: hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity (traceable author statement from ProtInc).
GO:0019901;	Molecular function: protein kinase binding (inferred from sequence or structural similarity from UniProtKB).
GO:0003700;	Molecular function: transcription factor activity (traceable author statement from ProtInc).
GO:0008134;	Molecular function: transcription factor binding (inferred from physical interaction from UniProtKB).
GO:0006928;	Biological process: cell motion (traceable author statement from ProtInc).
GO:0032870;	Biological process: cellular response to hormone stimulus (inferred from direct assay from UniProtKB).
GO:0070102;	Biological process: interleukin-6-mediated signaling pathway (inferred from direct assay from UniProtKB).
GO:0044419;	Biological process: interspecies interaction between organisms (inferred from electronic annotation from UniProtKB-KW).
GO:0060397;	Biological process: JAK-STAT cascade involved in growth hormone signaling pathway (inferred from direct assay from UniProtKB).
GO:0000122;	Biological process: negative regulation of transcription from RNA polymerase II promoter (traceable author statement from ProtInc).
GO:0007399;	Biological process: nervous system development (traceable author statement from ProtInc).
GO:0032355;	Biological process: response to estradiol stimulus (inferred from direct assay from UniProtKB).
GO:0006350;	Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR011992; EF-Hand_type.
IPR000980; SH2.
IPR013800; STAT_TF_alpha.
IPR001217; STAT_TF_core.
IPR013801; STAT_TF_DNA-bd.
IPR012345; STAT_TF_DNA-bd_sub.
IPR013799; STAT_TF_prot_interaction.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.238.10; EF-Hand_type; 1.
G3DSA:3.30.505.10; SH2; 1.
G3DSA:1.20.1050.20; STAT_alpha; 1.
G3DSA:2.60.40.630; STAT_DNA_bd_sub; 1.
G3DSA:1.10.532.10; STAT_protein_interaction; 1.

PANTHER

PTHR11801; STAT; 1.

Pfam

PF00017; SH2; 1.
PF01017; STAT_alpha; 1.
PF02864; STAT_bind; 1.
PF02865; STAT_int; 1.
Pfam graphical view of domain structure.

SMART

SM00252; SH2; 1.
SMART graphical view of domain structure.

PROSITE

PS50001; SH2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PeptideAtlas

P40763; -.

PRIDE

P40763; -.

Genome annotation databases

Ensembl

ENSG00000168610; Homo sapiens. [Contig view]

GeneID

6774; -.

KEGG

hsa:6774; -.

Phylogenomic databases

HOVERGEN

P40763; -.

OMA

P40763; KSQGDMQ.

Other

26438; -.

P40763; -.

STAT3; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Activator; Alternative splicing; Cytoplasm; Disease mutation; DNA-binding; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; SH2 domain; Transcription; Transcription regulation.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 770`	`770`	`Signal transducer and activator of transcription 3.`	`PRO_0000182417`
`DOMAIN`	`580 670`	`91`	`SH2.`
`MOTIF`	`150 162`	`13`	`Essential for nuclear import (By similarity).`
`MOD_RES`	`691 691`		`Phosphoserine.`
`MOD_RES`	`705 705`		`Phosphotyrosine.`
`MOD_RES`	`714 714`		`Phosphothreonine.`
`MOD_RES`	`727 727`		`Phosphoserine; by NLK.`
`VAR_SEQ`	`701 701`		`Missing (in isoform Del-701).`	`VSP_010474`
`VARIANT`	`32 32`	`1`	`Q -> K (in dbSNP:rs1803125 [NCBI]).`	`VAR_018683`
`VARIANT`	`143 143`	`1`	`M -> I (in dbSNP:rs17878478 [NCBI]).`	`VAR_018679 [3D]`
`VARIANT`	`382 382`	`1`	`R -> L (in AD-HIES).`	`VAR_037365 [3D]`
`VARIANT`	`382 382`	`1`	`R -> Q (in AD-HIES; loss of function).`	`VAR_037366 [3D]`
`VARIANT`	`382 382`	`1`	`R -> W (in AD-HIES; loss of function).`	`VAR_037367 [3D]`
`VARIANT`	`384 384`	`1`	`F -> L (in AD-HIES).`	`VAR_037368 [3D]`
`VARIANT`	`384 384`	`1`	`F -> S (in AD-HIES).`	`VAR_037369 [3D]`
`VARIANT`	`389 389`	`1`	`T -> I (in AD-HIES; loss of function).`	`VAR_037370 [3D]`
`VARIANT`	`423 423`	`1`	`R -> Q (in AD-HIES).`	`VAR_037371 [3D]`
`VARIANT`	`437 437`	`1`	`H -> Y (in AD-HIES; loss of function).`	`VAR_037372 [3D]`
`VARIANT`	`463 463`	`1`	`Missing (in AD-HIES; loss of function).`	`VAR_037373`
`VARIANT`	`561 561`	`1`	`F -> Y (in dbSNP:rs1064116 [NCBI]).`	`VAR_037374 [3D]`
`VARIANT`	`611 611`	`1`	`S -> N (in AD-HIES).`	`VAR_037375 [3D]`
`VARIANT`	`621 621`	`1`	`F -> V (in AD-HIES).`	`VAR_037376 [3D]`
`VARIANT`	`622 622`	`1`	`T -> I (in AD-HIES).`	`VAR_037377 [3D]`
`VARIANT`	`637 637`	`1`	`V -> L (in AD-HIES).`	`VAR_037378 [3D]`
`VARIANT`	`637 637`	`1`	`V -> M (in AD-HIES).`	`VAR_037379 [3D]`
`VARIANT`	`644 644`	`1`	`Missing (in AD-HIES).`	`VAR_037380`
`VARIANT`	`657 657`	`1`	`Y -> C (in AD-HIES).`	`VAR_037381 [3D]`
`CONFLICT`	`288 288`		`Q -> H (in Ref. 1; AAA58374).`
`CONFLICT`	`460 460`		`P -> S (in Ref. 1; AAA58374).`
`CONFLICT`	`548 548`		`K -> N (in Ref. 1; AAA58374).`
`CONFLICT`	`667 667`		`V -> L (in Ref. 1; AAA58374).`
`CONFLICT`	`730 730`		`T -> A (in Ref. 1; AAA58374).`

Sequence information

Length: 770 AA [This is the length of the unprocessed precursor]

Molecular weight: 88068 Da [This is the MW of the unprocessed precursor]

CRC64: 6C00632211C8012D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL 

        70         80         90        100        110        120 
LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA 

       130        140        150        160        170        180 
TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK 

       190        200        210        220        230        240 
SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL 

       250        260        270        280        290        300 
ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 

       310        320        330        340        350        360 
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY 

       370        380        390        400        410        420 
QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN 

       430        440        450        460        470        480 
GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY 

       490        500        510        520        530        540 
NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS 

       550        560        570        580        590        600 
GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 

       610        620        630        640        650        660 
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM 

       670        680        690        700        710        720 
DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN 

       730        740        750        760        770 
TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG QFESLTFDME LTSECATSPM

P40763 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools