[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=129;
DOI=10.1083/jcb.121.3.491; PubMed=8486731 [NCBI, ExPASy, EBI, Israel, Japan]
Itoh M.,
Nagafuchi A.,
Yonemura S.,
Yasuda-Kitani T.,
Tsukita S.,
Tsukita S.;
"The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.";
J. Cell Biol. 121:491-502(1993).
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[2]
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INTERACTION WITH KIRREL1.
STRAIN=Swiss Webster;
TISSUE=Brain;
DOI=10.1096/fj.02-0242fje; PubMed=12424224 [NCBI, ExPASy, EBI, Israel, Japan]
Sellin L.,
Huber T.B.,
Gerke P.,
Quack I.,
Pavenstaedt H.,
Walz G.;
"NEPH1 defines a novel family of podocin interacting proteins.";
FASEB J. 17:115-117(2003).
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[3]
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INTERACTION WITH GJA12, AND DOMAIN.
DOI=10.1016/j.neuroscience.2004.03.063; PubMed=15183511 [NCBI, ExPASy, EBI, Israel, Japan]
Li X.,
Ionescu A.V.,
Lynn B.D.,
Lu S.,
Kamasawa N.,
Morita M.,
Davidson K.G.V.,
Yasumura T.,
Rash J.E.,
Nagy J.I.;
"Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain.";
Neuroscience 126:611-630(2004).
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[4]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1139 AND TYR-1353, AND MASS SPECTROMETRY.
TISSUE=Mast cell;
PubMed=17947660 [NCBI, ExPASy, EBI, Israel, Japan]
Cao L.,
Yu K.,
Banh C.,
Nguyen V.,
Ritz A.,
Raphael B.J.,
Kawakami Y.,
Kawakami T.,
Salomon A.R.;
"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.";
J. Immunol. 179:5864-5876(2007).
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[5]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175; SER-284; SER-297; SER-300 AND SER-617, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1073/pnas.0609836104; PubMed=17242355 [NCBI, ExPASy, EBI, Israel, Japan]
Villen J.,
Beausoleil S.A.,
Gerber S.A.,
Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
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- FUNCTION: The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions.
- SUBUNIT: Interacts with CGN/cingulin, CXADR, GJD3 and HSPA4 (By similarity). Interacts with occludin, claudins, GJA12, KIRREL1 and TJP3/ZO-3.
- INTERACTION:
P57780:Actn4; NbExp=3; IntAct=EBI-79508, EBI-445071;
Q9P2M7:CGN (xeno); NbExp=1; IntAct=EBI-79508, EBI-79537;
Q9PTD7:cgn (xeno); NbExp=1; IntAct=EBI-79508, EBI-79525;
- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell junction, tight junction (By similarity). Note=Movement of ZO-1 from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact (By similarity).
- DOMAIN: The second PDZ domain mediates interaction with GJA12.
- SIMILARITY: Belongs to the MAGUK family.
- SIMILARITY: Contains 1 guanylate kinase-like domain.
- SIMILARITY: Contains 3 PDZ (DHR) domains.
- SIMILARITY: Contains 1 SH3 domain.
- SIMILARITY: Contains 1 ZU5 domain.
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