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UniProtKB/Swiss-Prot entry P38787

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PANE_YEAST
Primary accession number P38787
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1995
Sequence was last modified on February 1, 1995 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name 2-dehydropantoate 2-reductase
Synonyms EC 1.1.1.169
Ketopantoate reductase
KPA reductase
KPR
Gene name
Name: PAN5
OrderedLocusNames: YHR063C
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204511 / S288c / AB972;
PubMed=8091229 [NCBI, ExPASy, EBI, Israel, Japan]
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.;
"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.";
Science 265:2077-2082(1994).
[2]
 LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U00061; AAB68390.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S46711; S46711.
RefSeq NP_011930.1; -.
3D structure databases
ModBase P38787.
Protein-protein interaction databases
DIP DIP:5591N; -.
IntAct P38787; -.
Organism-specific databases
CYGD YHR063c; -.
SGD S000001105; PAN5.
Yeast-GFP YHR063C.
Gene expression databases
GermOnline YHR063C; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from SGD).
GO:0005625; Cellular component: soluble fraction (inferred from direct assay from SGD).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR003710; ApbA.
IPR013752; ApbA_C.
IPR013332; ApbA_N.
IPR013328; DHase_multihelical.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR21708:SF21; ApbA; 1.
Pfam PF02558; ApbA; 1.
PF08546; ApbA_C; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00745; apbA_panE; 1.
BLOCKS P38787.
Proteomic databases
PeptideAtlas P38787; -.
Genome annotation databases
Ensembl YHR063C; Saccharomyces cerevisiae. [Contig view]
GeneID 856460; -.
GenomeReviews U00093_GR; YHR063C.
KEGG sce:YHR063C; -.
NMPDR fig|4932.3.peg.3083; -.
Phylogenomic databases
HOGENOM P38787; -.
Other
LinkHub P38787; -.
ProtoNet P38787.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase; Pantothenate biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   379  379     2-dehydropantoate 2-reductase. PRO_0000157328
NP_BIND   13    18  6     NADP (By similarity). 
ACT_SITE   224   224        Proton donor (By similarity). 
BINDING   119   119        NADP; via amide nitrogen (By similarity). 
BINDING   119   119        Substrate (By similarity). 
BINDING   228   228        Substrate (By similarity). 
BINDING   232   232        Substrate (By similarity). 
BINDING   316   316        Substrate (By similarity). 
BINDING   328   328        NADP (By similarity). 
Sequence information
Length: 379 AA [This is the length of the unprocessed precursor] Molecular weight: 42821 Da [This is the MW of the unprocessed precursor] CRC64: 22BCAB56B2AE1AF3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTAPHRSTIH ILGLGAMGTV LAVDLLRFTN ALVVPLFRSQ ERLAQFQKTN GNNISIRKLY 

        70         80         90        100        110        120 
LEGSPIFSYP VEKCECPETF SKKPIDNLVV TTKTYQTKEA LAPYLPYINK NTNLILIQNG 

       130        140        150        160        170        180 
LGVLELLREE IFTDSKNRPH LFQGVISHGV YQDKAGVFNH AGWAGMKIAK LPWTEEEMIQ 

       190        200        210        220        230        240 
KKSVVEDDAA NNSLVKLLTE PKFAKEFGIE HSTYQEMLFG QLFKFLVNAC MNPVTAILDC 

       250        260        270        280        290        300 
VNGEMKASCG PVFTSIIDEC LQILRVAYRP LFQYHEKYSG NEEYPEMDVN AVLTTDNMVS 

       310        320        330        340        350        360 
EVTRIGCDIN SRNSSSMRQD TLFLRDIEIE YINGYVVKLA DNLNLDPNCC KVNKTIGELA 

       370 
TMRLALNRSR SINGDWRKD
P38787 in FASTA format

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