[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Sprague-Dawley; TISSUE=Pituitary; DOI=10.1006/bbrc.1993.1286; PubMed=8385453 [NCBI, ExPASy, EBI, Israel, Japan] Tsuchida K., Lewis K.A., Mathews L.S., Vale W.W.; "Molecular characterization of rat transforming growth factor-beta type II receptor."; Biochem. Biophys. Res. Commun. 191:790-795(1993).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=8264154 [NCBI, ExPASy, EBI, Israel, Japan] Choi M.E., Kim E.G., Huang Q., Ballermann B.J.; "Rat mesangial cell hypertrophy in response to transforming growth factor-beta 1."; Kidney Int. 44:948-958(1993).

Comments

FUNCTION: Acts as a signal transducer. Phosphorylates TGFBR1 upon binding to its ligand, TGF-beta. TGFBR1 in turn phosphorylates the cytoplasmic effectors of the pathway, known as SMADs.
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBUNIT: Binds to DAXX. Interacts with TCTEX1D4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L09653; AAA42237.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S67770; AAB29352.2; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

JN0459; JN0459.

NP_112394.3; -.

3D structure databases

HSSP

P37173; 1M9Z. [HSSP ENTRY / PDB]

SMR

P38438; 40-159.

ModBase

P38438.

Organism-specific databases

RGD

69651; Tgfbr2.

GeneLynx

Tgfbr2; Rattus norvegicus.

Gene expression databases

ArrayExpress

P38438; -.

GermOnline

ENSRNOG00000013265; Rattus norvegicus.

Family and domain databases

InterPro

IPR000333; Activin_II_recpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR008271; Ser_thr_pkin_AS.
IPR015769; TGF-beta_II_C.
IPR015013; TGF_beta_receptor2.
IPR017194; TGFRII.
Graphical view of domain structure.

PANTHER

PTHR23255:SF11; TGF-beta_II_C; 1.

Pfam

PF08917; ecTbetaR2; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF037393; TGFRII; 1.

PRINTS

PR00653; ACTIVIN2R.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P38438.

Genome annotation databases

Ensembl

ENSRNOG00000013265; Rattus norvegicus. [Contig view]

GeneID

81810; -.

KEGG

rno:81810; -.

Phylogenomic databases

HOVERGEN

P38438; -.

Other

ProtoNet

P38438.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 23`	`23`	`Potential.`
`CHAIN`	`24 567`	`544`	`TGF-beta receptor type-2.`	`PRO_0000024429`
`TOPO_DOM`	`24 166`	`143`	`Extracellular (Potential).`
`TRANSMEM`	`167 187`	`21`	`Potential.`
`TOPO_DOM`	`188 567`	`380`	`Cytoplasmic (Potential).`
`DOMAIN`	`244 546`	`303`	`Protein kinase.`
`NP_BIND`	`250 258`	`9`	`ATP (By similarity).`
`ACT_SITE`	`379 379`		`Proton acceptor (By similarity).`
`BINDING`	`277 277`		`ATP (By similarity).`
`MOD_RES`	`548 548`		`Phosphoserine (By similarity).`
`CARBOHYD`	`70 70`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`94 94`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`51 84`		`By similarity.`
`DISULFID`	`54 71`		`By similarity.`
`DISULFID`	`61 67`		`By similarity.`
`DISULFID`	`77 101`		`By similarity.`
`DISULFID`	`121 136`		`By similarity.`
`DISULFID`	`138 143`		`By similarity.`
`CONFLICT`	`388 389`		`KN -> RS (in Ref. 2; AAB29352).`
`CONFLICT`	`403 403`		`R -> G (in Ref. 2).`
`CONFLICT`	`405 405`		`D -> S (in Ref. 2).`
`CONFLICT`	`477 477`		`K -> R (in Ref. 2; AAB29352).`

Sequence information

Length: 567 AA [This is the length of the unprocessed precursor]

Molecular weight: 64241 Da [This is the MW of the unprocessed precursor]

CRC64: EC1D7642A51A3B75 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGRGLLRGLW PLHIVLWTRI ASTIPPHVPK SVNSDLMAGD NSGAVKLPQL CKFCDVTLST 

        70         80         90        100        110        120 
CDNQKSCMSN CSVTSICEKP QEVCVAVWRK NDKNITLETV CHDPKFTYHG FTLEDATSPT 

       130        140        150        160        170        180 
CVMKEKKRAG ETFFMCSCNT EECNDYIIFN EEYTTSSPDL LLVIIQVTGV SLLPPLGIAI 

       190        200        210        220        230        240 
AVIAIFYCYR VHRQQKLSPS WESSKPRKLM DFSDNCAIIL EDDRSDISST CANNINHNTE 

       250        260        270        280        290        300 
LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYSSWKTE KDIFSDINLK 

       310        320        330        340        350        360 
HENILQFLTA EERKTEMGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL GSSLARGIAH 

       370        380        390        400        410        420 
LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG 

       430        440        450        460        470        480 
TARYMAPEVL ESRMNLENME SFKQTDVYSM ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE 

       490        500        510        520        530        540 
HPCVESMKDN VLRDRGRPEI PSFWLNHQGI QIVCETLTEC WDHDPEARLT AQCVAERFSE 

       550        560 
LEHPDRLSGR SCSQEKIPED GSLNTTK

P38438 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools