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UniProtKB/Swiss-Prot entry P38432


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name P80C_HUMAN
Primary accession number P38432
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1994
Sequence was last modified on October 1, 1994 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 80)
Name and origin of the protein
Protein name Coilin
Synonym p80
Gene name
Name: COIL
Synonyms: CLN80
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1093/nar/22.21.4462; PubMed=7971277 [NCBI, ExPASy, EBI, Israel, Japan]
Chan E.K.L., Takano S., Andrade L.E.C., Hamel J.C., Matera A.G.;
"Structure, expression and chromosomal localization of human p80-coilin gene.";
Nucleic Acids Res. 22:4462-4469(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 172-576.
TISSUE=Liver;
DOI=10.1084/jem.173.6.1407; PubMed=2033369 [NCBI, ExPASy, EBI, Israel, Japan]
Andrade L.E.C., Chan E.K.L., Raska I., Peebles C.L., Roos G., Tan E.M.;
"Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin.";
J. Exp. Med. 173:1407-1419(1991).
[4]
CHARACTERIZATION.
DOI=10.1083/jcb.120.4.841; PubMed=7679389 [NCBI, ExPASy, EBI, Israel, Japan]
Carmo-Fonseca M., Ferreira J., Lamond A.I.;
"Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis -- evidence that the coiled body is a kinetic nuclear structure.";
J. Cell Biol. 120:841-852(1993).
[5]
INTERACTION WITH ANKS1B.
DOI=10.1186/1471-2121-6-23; PubMed=15862129 [NCBI, ExPASy, EBI, Israel, Japan]
Xu H., Hebert M.D.;
"A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin.";
BMC Cell Biol. 6:23-23(2005).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-303, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122 AND SER-489, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0507066103; PubMed=16565220 [NCBI, ExPASy, EBI, Israel, Japan]
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
"Phosphoproteome analysis of the human mitotic spindle.";
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0611217104; PubMed=17287340 [NCBI, ExPASy, EBI, Israel, Japan]
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122; SER-271; THR-290; SER-301; THR-303 AND SER-489, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[12]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M58411; AAA36412.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC010385; AAH10385.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U06632; AAB81550.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00006442; -.
PIR S50113; S50113.
RefSeq NP_004636.1; -.
UniGene Hs.532795
3D structure databases
ModBase P38432.
Protein-protein interaction databases
IntAct P38432; 49.
PTM databases
PhosphoSite P38432; -.
Organism-specific databases
GeneCards GC17M052370; -.
H-InvDB HIX0014015; -.
HGNC HGNC:2184; COIL.
GenAtlas COIL.
HPA CAB017524; -.
MIM 600272; gene. [NCBI / EBI]
PharmGKB PA26700; -.
Gene expression databases
ArrayExpress P38432; -.
Bgee P38432; -.
CleanEx HS_COIL; -.
GermOnline ENSG00000121058; Homo sapiens.
Ontologies
GO
GO:0015030; Cellular component: Cajal body (inferred from direct assay from UniProtKB).
GO:0005730; Cellular component: nucleolus (inferred from direct assay from UniProtKB).
GO:0008022; Molecular function: protein C-terminus binding (inferred from physical interaction from UniProtKB).
QuickGo view.
Proteomic databases
PeptideAtlas P38432; -.
PRIDE P38432; -.
Genome annotation databases
Ensembl ENSG00000121058; Homo sapiens. [Contig view]
GeneID 8161; -.
KEGG hsa:8161; -.
Phylogenomic databases
HOGENOM P38432; -.
HOVERGEN P38432; -.
OMA P38432; RQRFGFS.
Other
NextBio 30832; -.
SOURCE COIL; Homo sapiens.
ProtoNet P38432.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Nucleus; Phosphoprotein; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   576  576     Coilin. PRO_0000058146
REPEAT   223   226  4     1-1. 
REPEAT   268   271  4     1-2. 
REPEAT   386   389  4     2-1. 
REPEAT   413   414  2     3-1. 
REPEAT   415   416  2     3-2. 
REPEAT   417   418  2     3-3. 
REPEAT   419   420  2     3-4. 
REPEAT   517   520  4     2-2. 
REGION   223   271  49     2 X 4 AA repeats of A-R-N-S. 
REGION   386   520  135     2 X 4 AA repeats of S-L-P-A. 
REGION   413   420  8     4 X 2 AA tandem repeats of R-G. 
COMPBIAS   181   201  21     Lys-rich (basic). 
COMPBIAS   243   252  10     Ser/Thr-rich. 
COMPBIAS   310   320  11     Ser/Thr-rich. 
MOD_RES   122   122        Phosphothreonine. 
MOD_RES   271   271        Phosphoserine. 
MOD_RES   290   290        Phosphothreonine. 
MOD_RES   301   301        Phosphoserine. 
MOD_RES   303   303        Phosphothreonine. 
MOD_RES   489   489        Phosphoserine. 
Sequence information
Length: 576 AA [This is the length of the unprocessed precursor] Molecular weight: 62608 Da [This is the MW of the unprocessed precursor] CRC64: 879702B590F16849 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAASETVRLR LQFDYPPPAT PHCTAFWLLV DLNRCRVVTD LISLIRQRFG FSSGAFLGLY 

        70         80         90        100        110        120 
LEGGLLPPAE SARLVRDNDC LRVKLEERGV AENSVVISNG DINLSLRKAK KRAFQLEEGE 

       130        140        150        160        170        180 
ETEPDCKYSK KHWKSRENNN NNEKVLDLEP KAVTDQTVSK KNKRKNKATC GTVGDDNEEA 

       190        200        210        220        230        240 
KRKSPKKKEK CEYKKKAKNP KSPKVQAVKD WANQRCSSPK GSARNSLVKA KRKGSVSVCS 

       250        260        270        280        290        300 
KESPSSSSES ESCDESISDG PSKVTLEARN SSEKLPTELS KEEPSTKNTT ADKLAIKLGF 

       310        320        330        340        350        360 
SLTPSKGKTS GTTSSSSDSS AESDDQCLMS SSTPECAAGF LKTVGLFAGR GRPGPGLSSQ 

       370        380        390        400        410        420 
TAGAAGWRRS GSNGGGQAPG ASPSVSLPAS LGRGWGREEN LFSWKGAKGR GMRGRGRGRG 

       430        440        450        460        470        480 
HPVSCVVNRS TDNQRQQQLN DVVKNSSTII QNPVETPKKD YSLLPLLAAA PQVGEKIAFK 

       490        500        510        520        530        540 
LLELTSSYSP DVSDYKEGRI LSHNPETQQV DIEILSSLPA LREPGKFDLV YHNENGAEVV 

       550        560        570 
EYAVTQESKI TVFWKELIDP RLIIESPSNT SSTEPA 

P38432 in FASTA format

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