[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=8145647 [NCBI, ExPASy, EBI, Israel, Japan] Hugouvieux-Cotte-Pattat N., Robert-Baudouy J.; "Molecular analysis of the Erwinia chrysanthemi region containing the kdgA and zwf genes."; Mol. Microbiol. 11:67-75(1994).

Comments

CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP⁺ = D-glucono-1,5-lactone 6-phosphate + NADPH.
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3 .
SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X74866; CAA52858.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S37053; S37053.

3D structure databases

HSSP

P11413; 1QKI. [HSSP ENTRY / PDB]

ModBase

P37986.

Family and domain databases

InterPro

IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR23429; G6PDH; 1.

Pfam

PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000110; G6PD; 1.

PRINTS

PR00079; G6PDHDRGNASE.

ProDom

PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00871; zwf; 1.

PROSITE

PS00069; G6P_DEHYDROGENASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Carbohydrate metabolism; Glucose metabolism; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 491`	`491`	`Glucose-6-phosphate 1-dehydrogenase.`	`PRO_0000068121`
`ACT_SITE`	`239 239`		`Proton acceptor (By similarity).`
`BINDING`	`18 18`		`NADP (By similarity).`
`BINDING`	`50 50`		`NADP (By similarity).`
`BINDING`	`177 177`		`Substrate (By similarity).`
`BINDING`	`181 181`		`Substrate (By similarity).`
`BINDING`	`344 344`		`Substrate (By similarity).`

Sequence information

Length: 491 AA [This is the length of the unprocessed precursor]

Molecular weight: 56034 Da [This is the MW of the unprocessed precursor]

CRC64: 67BE0D8DCA97D5A6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAVTSTAQAC DLVIFGAKGD LARRKLLPSL YQLEKAGHIH PETRIIGVGR AEWDRDAYIK 

        70         80         90        100        110        120 
VVREALETFL KEPLDPALWT TLSNRLDFCN LDVEDTEGFK RLGTMLDQQN RTTINYFAMP 

       130        140        150        160        170        180 
PSTFGAICRG LGQAGLNKEP ARVVMEKPLG TNLASSRVIN NQVAEFFNEC QVYRIDHYLG 

       190        200        210        220        230        240 
KETVLNLLAL RFANSLFANN WDNRTIDHVQ ITVAEEVGIE GRWGYFDQAG QMRDMIQNHL 

       250        260        270        280        290        300 
LQILTMIAMS PPADLSTDRI RDEKVKVLRS LRRIDRSNVH EVTVRGQYTS GFVQGKKVPG 

       310        320        330        340        350        360 
YLEEEGANKT SNTETFVAIR VDIDDWRWSG VPFYLRTGKR LPSKCSEVVV YFKNPALNLF 

       370        380        390        400        410        420 
HDSYQQLPQN KLIIRLQPDE GVEIQILNKI PGLDHKHRLQ TTKLDLSFSE TFNQQHLADA 

       430        440        450        460        470        480 
YERLLLETMR GIQALFVRRD EVEEAWKWVD SIMDAWAMDN DSPKPYQAGT WGPVASVAMI 

       490 
TRDGRSWNEV E

P37986 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools