[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Fibroblast; DOI=10.1016/0378-1119(94)90386-7; PubMed=8039710 [NCBI, ExPASy, EBI, Israel, Japan] Savini E., Biamonti G., Ciarrocchi G., Montecucco A.; "Cloning and sequence analysis of a cDNA coding for the murine DNA ligase I enzyme."; Gene 144:253-257(1994).
[2]	SEQUENCE REVISION. Montecucco A.; Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=129/Ola; DOI=10.1016/0378-1119(95)00222-R; PubMed=7642116 [NCBI, ExPASy, EBI, Israel, Japan] Jessop J.K., Melton D.W.; "Comparison between cDNA clones encoding murine DNA ligase I."; Gene 160:307-308(1995).
[4]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183 AND SER-188, AND MASS SPECTROMETRY. TISSUE=Liver; DOI=10.1073/pnas.0609836104; PubMed=17242355 [NCBI, ExPASy, EBI, Israel, Japan] Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; "Large-scale phosphorylation analysis of mouse liver."; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).

Comments

FUNCTION: This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA.
CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the ATP-dependent DNA ligase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U04674; AAA70403.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U19604; AAB60500.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

I48921; I48921.

NP_034845.2; -.

3D structure databases

P37913; 260-899.

PTM databases

P37913; -.

Organism-specific databases

MGI

MGI:101789; Lig1.

Gene expression databases

ArrayExpress

P37913; -.

CleanEx

MM_LIG1; -.

GermOnline

ENSMUSG00000056394; Mus musculus.

Ontologies

GO:0006260;	Biological process: DNA replication (inferred from mutant phenotype from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR012308; DNA_ligase_A_N.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.50.140; OB_NA_bd_sub; 1.

Pfam

PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
PF04675; DNA_ligase_A_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00574; dnl1; 1.

PROSITE

PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; 1.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P37913.

Genome annotation databases

Ensembl

ENSMUSG00000056394; Mus musculus. [Contig view]

GeneID

16881; -.

Phylogenomic databases

HOVERGEN

P37913; -.

Other

Lig1; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Cell cycle; Cell division; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding; Nucleus; Phosphoprotein.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 916`	`916`	`DNA ligase 1.`	`PRO_0000059571`
`ACT_SITE`	`566 566`		`N6-AMP-lysine intermediate (By similarity).`
`MOD_RES`	`49 49`		`Phosphoserine (By similarity).`
`MOD_RES`	`51 51`		`Phosphoserine (By similarity).`
`MOD_RES`	`183 183`		`Phosphoserine.`
`MOD_RES`	`188 188`		`Phosphoserine.`
`MOD_RES`	`193 193`		`Phosphothreonine (By similarity).`
`MOD_RES`	`229 229`		`Phosphoserine (By similarity).`
`MOD_RES`	`232 232`		`Phosphothreonine (By similarity).`

Sequence information

Length: 916 AA [This is the length of the unprocessed precursor]

Molecular weight: 102290 Da [This is the MW of the unprocessed precursor]

CRC64: 6310B044364FB0E7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MQRSIMSFFQ PTKEGKAKKP EKETPSSIRE KEPPPKVALK ERNQVVPESD SPVKRTGRKV 

        70         80         90        100        110        120 
AQVLSCEGED EDEAPGTPKV QKPVSDSEQS SPPSPDTCPE NSPVFNCSSP MDISPSGFPK 

       130        140        150        160        170        180 
RRTARKQLPK RTIQDTLEEQ NEDKTKTAKK RKKEEETPKE SLAEAEDIKQ KEEKEGDQLI 

       190        200        210        220        230        240 
VPSEPTKSPE SVTLTKTENI PVCKAGVKLK PQEEEQSKPP ARGAKTLSSF FTPRKPAVKT 

       250        260        270        280        290        300 
EVKQEESGTL RKEETKGTLD PANYNPSKNN YHPIEDACWK HGQKVPFLAV ARTFEKIEEV 

       310        320        330        340        350        360 
SARLKMVETL SNLLRSVVAL SPPDLLPVLY LSLNRLGPPQ QGLELGVGDG VLLKAVAQAT 

       370        380        390        400        410        420 
GRQLESIRAE VAEKGDVGLV AENSRSTQRL MLPPPPLTIS GVFTKFCDIA RLTGSASMAK 

       430        440        450        460        470        480 
KMDIIKGLFV ACRHSEARYI ARSLSGRLRL GLAEQSVLAA LAQAVSLTPP GQEFPTVVVD 

       490        500        510        520        530        540 
AGKGKTAEAR KMWLEEQGMI LKQTFCEVPD LDRIIPVLLE HGLERLPEHC KLSPGVPLKP 

       550        560        570        580        590        600 
MLAHPTRGVS EVLKRFEEVD FTCEYKYDGQ RAQIHVLEGG EVKIFSRNQE DNTGKYPDII 

       610        620        630        640        650        660 
SRIPKIKHPS VTSFILDTEA VAWDREKKQI QPFQVLTTRK RKEVDASEIQ VQVCLYAFDL 

       670        680        690        700        710        720 
IYLNGESLVR QPLSRRRQLL RENFVETEGE FVFTTSLDTK DTEQIAEFLE QSVKDSCEGL 

       730        740        750        760        770        780 
MVKTLDVDAT YEIAKRSHNW LKLKKDYLDG VGDTLDLVVI GAYLGRGKRA GRYGGFLLAA 

       790        800        810        820        830        840 
YDEESEELQA ICKLGTGFSD EELEEHHQSL QALVLPTPRP YVRIDGAVAP DHWLDPSIVW 

       850        860        870        880        890        900 
EVKCADLSLS PIYPAARGLV DKEKGISLRF PRFIRVRKDK QPEQATTSNQ VASLYRKQSQ 

       910 
IQNQQSSDLD SDVEDY

P37913 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools