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UniProtKB/Swiss-Prot entry P37254


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PABS_YEAST
Primary accession number P37254
Secondary accession numbers Q02982 Q6B1Q1
Integrated into Swiss-Prot on October 1, 1994
Sequence was last modified on February 21, 2006 (Sequence version 4)
Annotations were last modified on    July 22, 2008 (Entry version 91)
Name and origin of the protein
Protein name Aminodeoxychorismate synthase
Synonyms ADC synthase
EC 2.6.1.85
Para-aminobenzoate synthase
P-aminobenzoic acid synthase
PABA synthase
Gene name
Name: ABZ1
OrderedLocusNames: YNR033W
ORFNames: N3286
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
PubMed=8346682 [NCBI, ExPASy, EBI, Israel, Japan]
Edman J.C., Goldstein A.L., Erbe J.G.;
"Para-aminobenzoate synthase gene of Saccharomyces cerevisiae encodes a bifunctional enzyme.";
Yeast 9:669-675(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8725220 [NCBI, ExPASy, EBI, Israel, Japan]
Shen W.-C., Stanford D.R., Hopper A.K.;
"Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family.";
Genetics 143:699-712(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169873 [NCBI, ExPASy, EBI, Israel, Japan]
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.";
Nature 387:93-98(1997).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
DOI=10.1101/gr.6037607; PubMed=17322287 [NCBI, ExPASy, EBI, Israel, Japan]
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[5]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02026; PubMed=14562095 [NCBI, ExPASy, EBI, Israel, Japan]
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[6]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L15299; AAA34840.1; ALT_FRAME; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U43608; AAB49319.1; ALT_FRAME; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z71648; CAA96313.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY693029; AAT93048.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S63364; S63364.
RefSeq NP_014431.1; -.
3D structure databases
HSSP P05041; 1K0E. [HSSP ENTRY / PDB]
ModBase P37254.
Protein-protein interaction databases
DIP DIP:6278N; -.
IntAct P37254; -.
Organism-specific databases
CYGD YNR033w; -.
SGD S000005316; ABZ1.
Yeast-GFP YNR033W.
Gene expression databases
ArrayExpress P37254; -.
GermOnline YNR033W; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from SGD).
GO:0046820; Molecular function: 4-amino-4-deoxychorismate synthase activity (inferred from mutant phenotype from SGD).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0046482; Biological process: para-aminobenzoic acid metabolic process (inferred from mutant phenotype from SGD).
QuickGo view.
Family and domain databases
InterPro IPR006805; Anth_synth_I_N.
IPR006220; Anth_synthII.
IPR015890; Chorismate-bd_C.
IPR011702; GATASE.
IPR012998; GATase_1_AS.
IPR000991; GATase_class1_C.
IPR010117; PabB_fungal.
IPR005801; TRPE_1_chor_bd.
IPR006221; TrpG_papA.
Graphical view of domain structure.
Gene3D G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
PANTHER PTHR11236; TRPE_1_chor_bd; 1.
Pfam PF04715; Anth_synt_I_N; 1.
PF00425; Chorismate_bind; 1.
PF00117; GATase; 1.
Pfam graphical view of domain structure.
PRINTS PR00097; ANTSNTHASEII.
PR00096; GATASE.
ProDom PD000779; Anth_synth_chor; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01823; PabB-fungal; 1.
TIGR00566; trpG_papA; 1.
PROSITE PS51273; GATASE_TYPE_1; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P37254.
Proteomic databases
PeptideAtlas P37254; -.
Genome annotation databases
Ensembl YNR033W; Saccharomyces cerevisiae. [Contig view]
GeneID 855768; -.
GenomeReviews Y13139_GR; YNR033W.
KEGG sce:YNR033W; -.
NMPDR fig|4932.3.peg.5511; -.
Phylogenomic databases
HOGENOM P37254; -.
Other
DrugBank DB00259; Sulfanilamide.
LinkHub P37254; -.
ProtoNet P37254.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Folate biosynthesis; Glutamine amidotransferase; Multifunctional enzyme; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   787  787     Aminodeoxychorismate synthase. PRO_0000154142
DOMAIN   16   233  218     Glutamine amidotransferase type-1. 
REGION   304   787  484     PABB component. 
COMPBIAS   10    14  5     Poly-Gln. 
ACT_SITE   112   112        By similarity. 
ACT_SITE   207   207        By similarity. 
ACT_SITE   209   209        By similarity. 
CONFLICT   85    85        G -> D (in Ref. 4; AAT93048). 
CONFLICT   171   171        A -> P (in Ref. 1; AAA34840 and 2; AAB49319). 
CONFLICT   533   533        A -> T (in Ref. 1; AAA34840). 
CONFLICT   586   586        D -> Y (in Ref. 2; AAB49319). 
CONFLICT   590   591        CE -> FV (in Ref. 1; AAA34840). 
CONFLICT   721   721        G -> GL (in Ref. 2; AAB49319). 
CONFLICT   722   722        V -> G (in Ref. 1; AAA34840). 
CONFLICT   735   737        NGD -> FGF (in Ref. 1; AAA34840). 
Sequence information
Length: 787 AA [This is the length of the unprocessed precursor] Molecular weight: 88544 Da [This is the MW of the unprocessed precursor] CRC64: 13117891486B5B0E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLSDTIDTKQ QQQQLHVLFI DSYDSFTYNV VRLIEQQTDI SPGVNAVHVT TVHSDTFQSM 

        70         80         90        100        110        120 
DQLLPLLPLF DAIVVGPGPG NPNNGAQDMG IISELFENAN GKLDEVPILG ICLGFQAMCL 

       130        140        150        160        170        180 
AQGADVSELN TIKHGQVYEM HLNDAARACG LFSGYPDTFK STRYHSLHVN AEGIDTLLPL 

       190        200        210        220        230        240 
CTTEDENGIL LMSAQTKNKP WFGVQYHPES CCSELGGLLV SNFLKLSFIN NVKTGRWEKK 

       250        260        270        280        290        300 
KLNGEFSDIL SRLDRTIDRD PIYKVKEKYP KGEDTTYVKQ FEVSEDPKLT FEICNIIREE 

       310        320        330        340        350        360 
KFVMSSSVIS ENTGEWSIIA LPNSASQVFT HYGAMKKTTV HYWQDSEISY TLLKKCLDGQ 

       370        380        390        400        410        420 
DSDLPGSLEV IHEDKSQFWI TLGKFMENKI IDNHREIPFI GGLVGILGYE IGQYIACGRC 

       430        440        450        460        470        480 
NDDENSLVPD AKLVFINNSI VINHKQGKLY CISLDNTFPV ALEQSLRDSF VRKKNIKQSL 

       490        500        510        520        530        540 
SWPKYLPEEI DFIITMPDKL DYAKAFKKCQ DYMHKGDSYE MCLTTQTKVV PSAVIEPWRI 

       550        560        570        580        590        600 
FQTLVQRNPA PFSSFFEFKD IIPRQDETPP VLCFLSTSPE RFLKWDADTC ELRPIKGTVK 

       610        620        630        640        650        660 
KGPQMNLAKA TRILKTPKEF GENLMILDLI RNDLYELVPD VRVEEFMSVQ EYATVYQLVS 

       670        680        690        700        710        720 
VVKAHGLTSA SKKTRYSGID VLKHSLPPGS MTGAPKKITV QLLQDKIESK LNKHVNGGAR 

       730        740        750        760        770        780 
GVYSGVTGYW SVNSNGDWSV NIRCMYSYNG GTSWQLGAGG AITVLSTLDG ELEEMYNKLE 


SNLQIFM 

P37254 in FASTA format

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