NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0166-6851(93)90032-S; PubMed=8396206 [NCBI, ExPASy, EBI, Israel, Japan]
Skelly P.J., Stein L.D., Shoemaker C.B.;
"Expression of Schistosoma mansoni genes involved in anaerobic and oxidative glucose metabolism during the cercaria to adult transformation.";
Mol. Biochem. Parasitol. 60:93-104(1993).

Comments

CATALYTIC ACTIVITY: (S)-malate + NAD⁺ = oxaloacetate + NADH.
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion matrix.
DEVELOPMENTAL STAGE: Expressed in relatively high level in adults as compared to larval worms.
SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L10108; AAA29901.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P00346; 1MLD. [HSSP ENTRY / PDB]

SMR

P37227; 1-142.

ModBase

P37227.

Ontologies

GO:0005759;	Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR001236; Lactate/malate_DHase.
IPR001252; Malate_DHase_AS.
IPR010097; Malate_DHase_NAD-dep_euk_g_bac.
Graphical view of domain structure.

PANTHER

PTHR11540:SF1; MDH_euk_g_bac; 1.

Pfam

PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS00068; MDH; PARTIAL.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Mitochondrion; NAD; Oxidoreductase; Tricarboxylic acid cycle.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 >142`	`>142`	`Malate dehydrogenase, mitochondrial.`	`PRO_0000113340`
`NP_BIND`	`1 6`	`6`	`NAD (By similarity).`
`NP_BIND`	`109 111`	`3`	`NAD (By similarity).`
`BINDING`	`26 26`		`NAD (By similarity).`
`BINDING`	`73 73`		`Substrate (By similarity).`
`BINDING`	`79 79`		`Substrate (By similarity).`
`BINDING`	`86 86`		`NAD (By similarity).`
`BINDING`	`111 111`		`Substrate (By similarity).`
`NON_TER`	`1 1`
`NON_TER`	`142 142`

Sequence information

Length: 142 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 14956 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: C06BC6726566AE72 [This is a checksum on the sequence]

        10         20         30         40         50         60 
ASGGIGEPLS LLLKQSPLIS QLALYDIAHV KGVAADLSHI ETQAHVTAHL GPGELAECLT 

        70         80         90        100        110        120 
GANVVIIPAG LPRKPGMTRD DLFNTNASIV AELIDSCAKN CPKAMICIIT NPVNSTVPIA 

       130        140 
AEILKRHNVY DPKRLFGVTT LD

P37227 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools