ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P37224

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name MAOM_AMAHP
Primary accession number P37224
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1994
Sequence was last modified on October 1, 1994 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 56)
Name and origin of the protein
Protein name NAD-dependent malic enzyme 65 kDa isoform, mitochondrial [Precursor]
Synonyms NAD-ME
EC 1.1.1.39
Gene name None
From
Amaranthus hypochondriacus (Prince-of-Wales feather) [TaxID: 28502] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; Caryophyllales; Amaranthaceae; Amaranthus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed=8300616 [NCBI, ExPASy, EBI, Israel, Japan]
Long J.J., Wang J.-L., Berry J.O.;
"Cloning and analysis of the C4 photosynthetic NAD-dependent malic enzyme of amaranth mitochondria.";
J. Biol. Chem. 269:2827-2833(1994).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U01162; AAA19014.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A49983; A49983.
3D structure databases
HSSP P40927; 1GQ2. [HSSP ENTRY / PDB]
ModBase P37224.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS P37224.
Other
ProtoNet P37224.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    31  31     Mitochondrion. 
CHAIN   32   623  592     NAD-dependent malic enzyme 65 kDa isoform, mitochondrial. PRO_0000018542
ACT_SITE   143   143        Proton donor (Potential). 
ACT_SITE   214   214        Proton acceptor (By similarity). 
METAL   285   285        Divalent metal cation (By similarity). 
METAL   286   286        Divalent metal cation (By similarity). 
METAL   309   309        Divalent metal cation (By similarity). 
BINDING   196   196        NAD (By similarity). 
BINDING   309   309        NAD (By similarity). 
BINDING   464   464        NAD (By similarity). 
SITE   309   309  1     Important for activity (By similarity). 
Sequence information
Length: 623 AA [This is the length of the unprocessed precursor] Molecular weight: 69688 Da [This is the MW of the unprocessed precursor] CRC64: 0B0917B8506FFE48 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLVLCSRSRL TSSLIRRLKD QIANVSNHRS FATSEGHRLA IVNKRSLDIL QDPWFNKGTA 

        70         80         90        100        110        120 
FSMTERDRLD LRGLLPPNVM TTEQQIERFT ADLRVLELTT KDGPSDTYDL AKWRILNRLH 

       130        140        150        160        170        180 
DRNETMFFKV LIENIEEYAP IVSTPTVGLV CQKFSGLYRR PRGMYFSSDD RGEMMSMVYN 

       190        200        210        220        230        240 
WPAEQVDMIV VTDGSRILGL GDLGVHGIGV AIGKLDLYVA AAGINPQRVL PVMIDVGTNN 

       250        260        270        280        290        300 
EDLLKNPLYL GLQKKRLDGE EYLAVMDEFM EAVFTRWPNV IVQFEDIQNK WALTLLQRYR 

       310        320        330        340        350        360 
HKYRTFNVDV QGTSGVAIAG LLGAVRAQGR PMIDFPKQKI VVAGAGSSGV GVLNAARKTM 

       370        380        390        400        410        420 
ARMLGNDESA FDRARSQFWV VDDKGLITEK RANLDPEVQP FAWKENEISL QGLNEGAKLV 

       430        440        450        460        470        480 
EVVRQVKPDV LLGLSAYGGL FSKEVLEALK DSTSTRPAIF AMSNPTKNAE CTPEEAFSIV 

       490        500        510        520        530        540 
GDHVVYASGS PFKDVDLGNG KIGHVNQGNN MYLFPGIGLG VLLSGSRIIS DSMFQAAAER 

       550        560        570        580        590        600 
LAGYMTDEEV INGVIYPSIS RIRDITKEVA AAVIKEAVEE DLAEGYRDMD ARELQKLNEE 

       610        620 
QILEYIEKNM WNPEYPTLVY KKR
P37224 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ch flag SIB Switzerland Mirror sites: Australia Brazil Canada China Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!