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UniProtKB/Swiss-Prot entry P37223

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAOX_MESCR
Primary accession number P37223
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1994
Sequence was last modified on October 1, 1994 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 52)
Name and origin of the protein
Protein name NADP-dependent malic enzyme
Synonyms NADP-ME
EC 1.1.1.40
Gene name
Name: MOD1
From
Mesembryanthemum crystallinum (Common ice plant) [TaxID: 3544] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; Caryophyllales; Aizoaceae; Mesembryanthemum.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Leaf;
PubMed=1521524 [NCBI, ExPASy, EBI, Israel, Japan]
Cushman J.C.;
"Characterization and expression of a NADP-malic enzyme cDNA induced by salt stress from the facultative crassulacean acid metabolism plant, Mesembryanthemum crystallinum.";
Eur. J. Biochem. 208:259-266(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X64434; CAA45772.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S43718; S43718.
3D structure databases
HSSP P40927; 1GQ2. [HSSP ENTRY / PDB]
ModBase P37223.
Family and domain databases
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS P37223.
Other
ProtoNet P37223.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Metal-binding; NADP; Oxidoreductase; Stress response.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   585  585     NADP-dependent malic enzyme. PRO_0000160200
NP_BIND   329   345  17     NADP (By similarity). 
ACT_SITE   133   133        Proton donor (By similarity). 
ACT_SITE   204   204        Proton acceptor (By similarity). 
METAL   276   276        Divalent metal cation (By similarity). 
METAL   277   277        Divalent metal cation (By similarity). 
METAL   300   300        Divalent metal cation (By similarity). 
BINDING   186   186        NAD (By similarity). 
BINDING   300   300        NAD (By similarity). 
BINDING   441   441        NAD (By similarity). 
SITE   300   300  1     Important for activity (By similarity). 
Sequence information
Length: 585 AA [This is the length of the unprocessed precursor] Molecular weight: 64358 Da [This is the MW of the unprocessed precursor] CRC64: C71675B67FB719D9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGGSNALNEM TNGSDGITGG VADVYGEEFA TQDQLVTPWS FSVACGHSLL RDPQHNKGLA 

        70         80         90        100        110        120 
FTEKERDAHF LRGLLPPVVL SQELQEKKFL TTLRQYQVPL QKYMAMMDLQ ERNEKLFYKL 

       130        140        150        160        170        180 
LVDHVEELLP LVYTPTVGEG CQKYGSIFRR PQGLFISLKD KGRILELLRN WPEKKIQVIV 

       190        200        210        220        230        240 
VTDGERILGL GDLGCQGMGI PVGKLSLYSA LGGVCPSACL PITLDVGTNN QKLLDDEFYI 

       250        260        270        280        290        300 
GLKQKRATGE EYAEFVQEFM SAVKQNYGEK ILVQFEDFAN HNAFELLEKY RTTHLVFNDD 

       310        320        330        340        350        360 
IQGTASVVLA GLIASLKLLG GTLADHKFLF LGAGEAGTGI AELIALEMSK KTKAPVEQMR 

       370        380        390        400        410        420 
KKIWLVDSKG LVVSSRKETL QQFKLPWAHE HEPITTLIDA VQAIKPTVLI GTSGKGKQFT 

       430        440        450        460        470        480 
KEVVEAMANI NAKPLILALS NPTSQSECTA EEAYTWSQGH AIFASGSPFD PVEYEGRTFV 

       490        500        510        520        530        540 
PGQANNAYIF PGFGLGLIMC GAIRVHDDML LAASEALASQ VTGEHFIKGL IYPPFKDIRK 

       550        560        570        580 
ISAHIAAGVA AKAYELGLAS RLPQPADLVK FAESCMYNPT YRSFR
P37223 in FASTA format

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