ID   DHON_METGL              Reviewed;         412 AA.
AC   P37144;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   22-JUL-2008, entry version 42.
DE   RecName: Full=Homoserine dehydrogenase;
DE            Short=HDH;
DE            EC=1.1.1.3;
GN   Name=hom;
OS   Methylobacillus glycogenes.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Methylophilales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=406;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 21371 / JCM 2853;
RX   MEDLINE=94161493; PubMed=8117070;
RA   Motoyama H., Maki K., Anazawa H., Ishino S., Teshiba S.;
RT   "Cloning and nucleotide sequences of the homoserine dehydrogenase
RT   genes (hom) and the threonine synthase genes (thrC) of the Gram-
RT   negative obligate methylotroph Methylobacillus glycogenes.";
RL   Appl. Environ. Microbiol. 60:111-119(1994).
CC   -!- CATALYTIC ACTIVITY: L-homoserine + NAD(P)(+) = L-aspartate 4-
CC       semialdehyde + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC   -!- SIMILARITY: Contains 1 ACT domain.
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DR   EMBL; D14071; BAA40415.1; -; Genomic_DNA.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR005106; Asp/hSer_DHase_NAD-bd.
DR   InterPro; IPR016204; hSer_DHase.
DR   InterPro; IPR001342; hSer_DHase_cat.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Isoleucine biosynthesis; Methionine biosynthesis; NADP;
KW   Oxidoreductase; Threonine biosynthesis.
FT   CHAIN         1    412       Homoserine dehydrogenase.
FT                                /FTId=PRO_0000066699.
FT   DOMAIN      329    404       ACT.
FT   NP_BIND       9     16       NADP (By similarity).
FT   ACT_SITE    205    205       Proton donor (Potential).
FT   BINDING     105    105       NADP (By similarity).
FT   BINDING     190    190       Substrate (By similarity).
SQ   SEQUENCE   412 AA;  44818 MW;  613A1B7FDECEF4AA CRC64;
     MKPINVGLLG IGTVGGGTYT VLTRNQEEIA RRAGRPIAIT RVADRNLELA RQVTGGKIDV
     TDDAFAIVSD PAIDIVVELI GGYTVARELV LKAIENGKHV VTANKALIAC MAMKFLPLRR
     KKASSSLLKL PLLVVSPLFK AVREGLAANR IEWIAGIING TTNFILSEMR EKGLAFADVL
     KEAQRLGYAE ADPTFDVEGI DAAHKLMILA AMLWLFVHSL CRGITKLDAV DITKRTDKGV
     ELRVHPTLIP EKRLICQCEW RNECCAGQGR CCWPTLYYGA GAGAEPTASA VADLVDGTDR
     GISCPHLAFQ PDRLVDLPIL PIGEISSAYY LRLRAVDKPG VLADVTRILG DRQISIDAMI
     QKEPQEGEDQ ADIIILTHVT VEKNMDDAIA AIEALPAISG KVTRLRMEEL SR
//