ID   BMR1B_MOUSE             Reviewed;         502 AA.
AC   P36898; Q3TRF2;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   22-JUL-2008, entry version 86.
DE   RecName: Full=Bone morphogenetic protein receptor type-1B;
DE            EC=2.7.11.30;
DE   AltName: Full=Serine/threonine-protein kinase receptor R6;
DE            Short=SKR6;
DE   AltName: Full=Activin receptor-like kinase 6;
DE            Short=ALK-6;
DE   AltName: CD_antigen=CDw293;
DE   Flags: Precursor;
GN   Name=Bmpr1b; Synonyms=Acvrlk6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=94188705; PubMed=8140412;
RA   ten Dijke P., Yamashita H., Ichijo H., Franzen P., Laiho M.,
RA   Miyazono K., Heldin C.-H.;
RT   "Characterization of type I receptors for transforming growth factor-
RT   beta and activin.";
RL   Science 264:101-104(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head, and Hypothalamus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6; TISSUE=Brain, and Retina;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: On ligand binding, forms a receptor complex consisting
CC       of two type II and two type I transmembrane serine/threonine
CC       kinases. Type II receptors phosphorylate and activate type I
CC       receptors which autophosphorylate, then bind and activate SMAD
CC       transcriptional regulators. Receptor for BMPS/OP-1.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 GS domain.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; Z23143; CAA80674.1; -; mRNA.
DR   EMBL; AK086130; BAC39617.1; -; mRNA.
DR   EMBL; AK162844; BAE37078.1; -; mRNA.
DR   EMBL; BC065106; AAH65106.1; -; mRNA.
DR   EMBL; BC065143; AAH65143.1; -; mRNA.
DR   PIR; A53444; A53444.
DR   RefSeq; NP_031586.1; -.
DR   UniGene; Mm.39089; -.
DR   HSSP; P36897; 1IAS.
DR   DIP; DIP:252N; -.
DR   Ensembl; ENSMUSG00000052430; Mus musculus.
DR   GeneID; 12167; -.
DR   KEGG; mmu:12167; -.
DR   MGI; MGI:107191; Bmpr1b.
DR   HOGENOM; P36898; -.
DR   HOVERGEN; P36898; -.
DR   ArrayExpress; P36898; -.
DR   CleanEx; MM_BMPR1B; -.
DR   GermOnline; ENSMUSG00000052430; Mus musculus.
DR   GO; GO:0005025; F:transforming growth factor beta receptor ac...; IMP:MGI.
DR   GO; GO:0030509; P:BMP signaling pathway; IMP:MGI.
DR   GO; GO:0001502; P:cartilage condensation; IMP:MGI.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IGI:MGI.
DR   GO; GO:0006703; P:estrogen biosynthetic process; NAS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEP:UniProtKB.
DR   GO; GO:0001550; P:ovarian cumulus expansion; IMP:UniProtKB.
DR   GO; GO:0060041; P:retina development in camera-type eye; IMP:MGI.
DR   GO; GO:0031290; P:retinal ganglion cell axon guidance; IMP:MGI.
DR   GO; GO:0007179; P:transforming growth factor beta receptor si...; TAS:MGI.
DR   InterPro; IPR000333; Activin_II_recpt.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR003605; TGF_beta_rcpt_GS.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   PRINTS; PR00653; ACTIVIN2R.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00467; GS; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Magnesium; Manganese; Membrane; Metal-binding;
KW   Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal;
KW   Transferase; Transmembrane.
FT   SIGNAL        1     13       Potential.
FT   CHAIN        14    502       Bone morphogenetic protein receptor type-
FT                                1B.
FT                                /FTId=PRO_0000024413.
FT   TOPO_DOM     14    126       Extracellular (Potential).
FT   TRANSMEM    127    148       Potential.
FT   TOPO_DOM    149    502       Cytoplasmic (Potential).
FT   DOMAIN      174    203       GS.
FT   DOMAIN      204    494       Protein kinase.
FT   NP_BIND     210    218       ATP (By similarity).
FT   ACT_SITE    332    332       Proton acceptor (By similarity).
FT   BINDING     231    231       ATP (By similarity).
SQ   SEQUENCE   502 AA;  56944 MW;  AB29681F3FF5A361 CRC64;
     MLLRSSGKLN VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED
     DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKDRDFVD
     GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQEARPRYS IGLEQDETYI PPGESLRDLI
     EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS
     WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDAKS
     MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD
     TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEI ARRCVSGGIV
     EEYQLPYHDL VPSDPSYEDM REIVCMKKLR PSFPNRWSSD ECLRQMGKLM TECWAQNPAS
     RLTALRVKKT LAKMSESQDI KL
//