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UniProtKB/Swiss-Prot entry P36896


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACV1B_HUMAN
Primary accession number P36896
Secondary accession numbers Q15479 Q15480 Q15481 Q15482
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on June 1, 1994 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 99)
Name and origin of the protein
Protein name Activin receptor type-1B [Precursor]
Synonyms EC 2.7.11.30
ACTR-IB
Serine/threonine-protein kinase receptor R2
SKR2
Activin receptor-like kinase 4
ALK-4
Gene name
Name: ACVR1B
Synonyms: ACVRLK4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
PubMed=8397373 [NCBI, ExPASy, EBI, Israel, Japan]
ten Dijke P., Ichijo H., Franzen P., Schulz P., Saras J., Toyoshima H., Heldin C.-H., Miyazono K.;
"Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.";
Oncogene 8:2879-2887(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
PubMed=8196624 [NCBI, ExPASy, EBI, Israel, Japan]
Carcamo J., Weis F.M., Ventura F., Wieser R., Wrana J.L., Attisano L., Massague J.;
"Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.";
Mol. Cell. Biol. 14:3810-3821(1994).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND ALTERNATIVE SPLICING.
TISSUE=Liver;
PubMed=8058741 [NCBI, ExPASy, EBI, Israel, Japan]
Xu J., Matsuzaki K., McKeehan K., Wang F., Kan M., McKeehan W.L.;
"Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition.";
Proc. Natl. Acad. Sci. U.S.A. 91:7957-7961(1994).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain, and Eye;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION AT TYR-380.
DOI=10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I; PubMed=12112843 [NCBI, ExPASy, EBI, Israel, Japan]
Maguire P.B., Wynne K.J., Harney D.F., O'Donoghue N.M., Stephens G., Fitzgerald D.J.;
"Identification of the phosphotyrosine proteome from thrombin activated platelets.";
Proteomics 2:642-648(2002).
[7]
VARIANT [LARGE SCALE ANALYSIS] LEU-146.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z22536; CAA80258.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U14722; AAA50246.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L10125; AAA60555.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L10126; AAA60556.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L31848; AAA53349.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L31848; AAA53350.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L31848; AAA53351.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT007072; AAP35735.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000254; AAH00254.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC040531; AAH40531.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I38859; I38859.
I80182; I80182.
I80183; I80183.
RefSeq NP_004293.1; -.
NP_064732.2; -.
NP_064733.2; -.
UniGene Hs.438918
3D structure databases
HSSP P36897; 1B6C. [HSSP ENTRY / PDB]
SMR P36896; 173-501.
ModBase P36896.
Protein-protein interaction databases
DIP DIP:427N; -.
IntAct P36896; -.
PTM databases
PhosphoSite P36896; -.
Organism-specific databases
H-InvDB HIX0010648; -.
HGNC HGNC:172; ACVR1B.
GeneLynx ACVR1B; Homo sapiens.
GenAtlas ACVR1B.
MIM 601300; gene. [NCBI / EBI]
PharmGKB PA24493; -.
GeneCards P36896.
Gene expression databases
ArrayExpress P36896; -.
CleanEx HS_ACVR1B; -.
Ontologies
GO
GO:0009986; Cellular component: cell surface (inferred from direct assay from HGNC).
GO:0005887; Cellular component: integral to plasma membrane (inferred from direct assay from HGNC).
GO:0016361; Molecular function: activin receptor activity, type I (traceable author statement from HGNC).
GO:0005524; Molecular function: ATP binding (inferred from direct assay from HGNC).
GO:0046332; Molecular function: SMAD binding (inferred from direct assay from HGNC).
GO:0000082; Biological process: G1/S transition of mitotic cell cycle (inferred from direct assay from HGNC).
GO:0006917; Biological process: induction of apoptosis (inferred from mutant phenotype from HGNC).
GO:0030308; Biological process: negative regulation of cell growth (inferred from direct assay from HGNC).
GO:0032927; Biological process: positive regulation of activin receptor signaling pathway (inferred from mutant phenotype from HGNC).
GO:0045648; Biological process: positive regulation of erythrocyte differentiation (inferred from direct assay from HGNC).
GO:0006468; Biological process: protein amino acid phosphorylation (inferred from direct assay from HGNC).
GO:0045449; Biological process: regulation of transcription (inferred from direct assay from HGNC).
QuickGo view.
Family and domain databases
InterPro IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR003605; TGF_beta_rcpt_GS.
Graphical view of domain structure.
Pfam PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
Pfam graphical view of domain structure.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00467; GS; 1.
SMART graphical view of domain structure.
PROSITE PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P36896.
Genome annotation databases
Ensembl ENSG00000135503; Homo sapiens. [Contig view]
GeneID 91; -.
KEGG hsa:91; -.
Phylogenomic databases
HOGENOM P36896; -.
HOVERGEN P36896; -.
Other
DrugBank DB00171; Adenosine triphosphate.
SOURCE ACVR1B; Homo sapiens.
ProtoNet P36896.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    23  23     Potential. 
CHAIN   24   505  482     Activin receptor type-1B. PRO_0000024417
TOPO_DOM   24   126  103     Extracellular (Potential). 
TRANSMEM   127   149  23     Potential. 
TOPO_DOM   150   505  356     Cytoplasmic (Potential). 
DOMAIN   177   206  30     GS. 
DOMAIN   207   497  291     Protein kinase. 
NP_BIND   213   221  9     ATP (By similarity). 
ACT_SITE   335   335        Proton acceptor (By similarity). 
BINDING   234   234        ATP (By similarity). 
MOD_RES   380   380        Phosphotyrosine. 
CARBOHYD   43    43        N-linked (GlcNAc...) (Potential). 
VAR_SEQ   422   505        VHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQ SYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQ EDVKI -> TFLFCLCSYLPFQDAGSPKAVLLPPFFLQPVGCLLPEPES SFKVAIKGVEVAVLRVRLFFRDQFVE (in isoform 3). VSP_004953
VAR_SEQ   465   505        ALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQ EDVKI -> VRSWPPAAFPSA (in isoform 2). VSP_004954
VARIANT   146   146  1     F -> L. VAR_041406 
VARIANT   408   408  1     L -> V (in dbSNP:rs928906 [NCBI]). VAR_011716 [3D]
CONFLICT   56    56        I -> F (in Ref. 3; AAA60555/AAA60556). 
CONFLICT   222   223        WR -> MA (in Ref. 3; AAA60555/AAA60556). 
Sequence information
Length: 505 AA [This is the length of the unprocessed precursor] Molecular weight: 56807 Da [This is the MW of the unprocessed precursor] CRC64: 40A6C65CAA4C7573 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAESAGASSF FPLVVLLLAG SGGSGPRGVQ ALLCACTSCL QANYTCETDG ACMVSIFNLD 

        70         80         90        100        110        120 
GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDY CNRIDLRVPS GHLKEPEHPS 

       130        140        150        160        170        180 
MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 

       190        200        210        220        230        240 
DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 

       250        260        270        280        290        300 
ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 

       310        320        330        340        350        360 
IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 

       370        380        390        400        410        420 
DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 

       430        440        450        460        470        480 
GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNIPNWW QSYEALRVMG KMMRECWYAN 

       490        500 
GAARLTALRI KKTLSQLSVQ EDVKI 

P36896 in FASTA format

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