[1]	NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE. PubMed=1438208 [NCBI, ExPASy, EBI, Israel, Japan] Kumar A., Shen P.S., Descoteaux S., Pohl J., Bailey G., Samuelson J.; "Cloning and expression of an NADP(+)-dependent alcohol dehydrogenase gene of Entamoeba histolytica."; Proc. Natl. Acad. Sci. U.S.A. 89:10188-10192(1992).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=1340318 [NCBI, ExPASy, EBI, Israel, Japan] Samuelson J., Zhang W.W., Kumar A., Descoteaux S., Shen P.S., Bailey G.; "Primary structures of alcohol and aldehyde dehydrogenase genes of Entamoeba histolytica."; Arch. Med. Res. 23:31-33(1992).

Comments

CATALYTIC ACTIVITY: An alcohol + NADP⁺ = an aldehyde + NADPH.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M88600; AAA51479.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A46409; A46409.

3D structure databases

PDB

1Y9A; X-ray; 1.81 A; A/C=1-360.	[ExPASy / RCSB / EBI]
2OUI; X-ray; 1.77 A; A/B/C/D=1-360.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

PDBsum

1Y9A; -.
2OUI; -.

ModBase

P35630.

Family and domain databases

InterPro

IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.

PANTHER

PTHR11695; ADH_Sf_Zn; 1.

Pfam

PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS00059; ADH_ZINC; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Cytoplasm; Direct protein sequencing; Metal-binding; NADP; Oxidoreductase; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 360`	`360`	`NADP-dependent alcohol dehydrogenase.`	`PRO_0000160695`
`METAL`	`37 37`		`Zinc; catalytic (By similarity).`
`METAL`	`59 59`		`Zinc; catalytic (By similarity).`
`METAL`	`60 60`		`Zinc; catalytic (By similarity).`
`METAL`	`150 150`		`Zinc; catalytic (By similarity).`
`STRAND`	`2 8`	`7`
`STRAND`	`11 16`	`6`
`STRAND`	`27 34`	`8`
`HELIX`	`38 45`	`8`
`STRAND`	`53 56`	`4`
`STRAND`	`61 68`	`8`
`STRAND`	`80 83`	`4`
`HELIX`	`93 96`	`4`
`HELIX`	`100 102`	`3`
`TURN`	`106 109`	`4`
`TURN`	`113 115`	`3`
`STRAND`	`119 128`	`10`
`HELIX`	`129 132`	`4`
`HELIX`	`142 145`	`4`
`HELIX`	`146 148`	`3`
`HELIX`	`151 161`	`11`
`STRAND`	`170 173`	`4`
`HELIX`	`177 188`	`12`
`STRAND`	`192 197`	`6`
`HELIX`	`201 209`	`9`
`STRAND`	`214 216`	`3`
`HELIX`	`218 220`	`3`
`HELIX`	`223 230`	`8`
`TURN`	`231 233`	`3`
`STRAND`	`236 241`	`6`
`HELIX`	`248 255`	`8`
`STRAND`	`256 264`	`9`
`STRAND`	`272 277`	`6`
`TURN`	`278 281`	`4`
`HELIX`	`282 284`	`3`
`STRAND`	`288 293`	`6`
`HELIX`	`298 310`	`13`
`HELIX`	`317 319`	`3`
`STRAND`	`320 326`	`7`
`HELIX`	`329 339`	`11`
`STRAND`	`345 350`	`6`
`TURN`	`354 358`	`5`

Sequence information

Length: 360 AA [This is the length of the unprocessed precursor]

Molecular weight: 38568 Da [This is the MW of the unprocessed precursor]

CRC64: 6D01643EB4A3A07F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKGLAMLGIG RIGWIEKKIP ECGPLDALVR PLALAPCTSD THTVWAGAIG DRHDMILGHE 

        70         80         90        100        110        120 
AVGQIVKVGS LVKRLKVGDK VIVPAITPDW GEEESQRGYP MHSGGMLGGW KFSNFKDGVF 

       130        140        150        160        170        180 
SEVFHVNEAD ANLALLPRDI KPEDAVMLSD MVTTGFHGAE LANIKLGDTV CVIGIGPVGL 

       190        200        210        220        230        240 
MSVAGANHLG AGRIFAVGSR KHCCDIALEY GATDIINYKN GDIVEQILKA TDGKGVDKVV 

       250        260        270        280        290        300 
IAGGDVHTFA QAVKMIKPGS DIGNVNYLGE GDNIDIPRSE WGVGMGHKHI HGGLTPGGRV 

       310        320        330        340        350        360 
RMEKLASLIS TGKLDTSKLI THRFEGLEKV EDALMLMKNK PADLIKPVVR IHYDDEDTLH

P35630 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools