ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P35613


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name BASI_HUMAN
Primary accession number P35613
Secondary accession numbers Q7Z796 Q8IZL7
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on August 31, 2004 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 106)
Name and origin of the protein
Protein name Basigin [Precursor]
Synonyms Leukocyte activation antigen M6
Collagenase stimulatory factor
Extracellular matrix metalloproteinase inducer
EMMPRIN
5F7
Tumor cell-derived collagenase stimulatory factor
TCSF
OK blood group antigen
CD147 antigen
Gene name
Name: BSG
ORFNames: UNQ6505/PRO21383
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
PubMed=1634773 [NCBI, ExPASy, EBI, Israel, Japan]
Kasinrerk W., Fiebiger E., Stefanova I., Baumruker T., Knapp W., Stockinger H.;
"Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule.";
J. Immunol. 149:847-854(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
PubMed=1783610 [NCBI, ExPASy, EBI, Israel, Japan]
Miyauchi T., Masuzawa Y., Muramatsu T.;
"The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen.";
J. Biochem. 110:770-774(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
PubMed=7812975 [NCBI, ExPASy, EBI, Israel, Japan]
Biswas C., Zhang Y., Decastro R., Guo H., Nakamura T., Kataoka H., Nabeshima K.;
"The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily.";
Cancer Res. 55:434-439(1995).
[4]
NUCLEOTIDE SEQUENCE (ISOFORM 2).
Wakasugi H., Scamps C., Yang G., Vancong N., Bernheim A., Tursz T., Harada N.;
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE (ISOFORM 2).
Decastro R., Zhang Y., Kataoka H., Coon J., Biswas C.;
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
DOI=10.1016/S0378-1119(98)00400-4; PubMed=9767135 [NCBI, ExPASy, EBI, Israel, Japan]
Guo H., Majmudar G., Jensen T.C., Biswas C., Toole B.P., Gordon M.K.;
"Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases.";
Gene 220:99-108(1998).
[7]
NUCLEOTIDE SEQUENCE (ISOFORM 2).
Sato T., Takita M., Noguchi Y., Hirata M., Sakai T., Ito A.;
"Regulation of EMMPRIN/CD147 expression and its function of controlling matrix metalloproteinases production and cell-surface localization in co-culture of human uterine cervical carcinoma SKG-II cells and human uterine cervical fibroblasts.";
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE (ISOFORM 2).
Kim D., Kanai Y., Choi H., Shin H., Kim J., Teraoka H., Shigeta Y., Chairoungdua A., Babu E., Anzai N., Iribe Y., Endou H.;
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE (ISOFORM 1).
TISSUE=Retina;
DOI=10.1167/iovs.02-0995; PubMed=12939332 [NCBI, ExPASy, EBI, Israel, Japan]
Ochrietor J.D., Moroz T.P., van Ekeris L., Clamp M.F., Jefferson S.C., deCarvalho A.C., Fadool J.M., Wistow G., Muramatsu T., Linser P.J.;
"Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily.";
Invest. Ophthalmol. Vis. Sci. 44:4086-4096(2003).
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[11]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
SeattleSNPs variation discovery resource;
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
[12]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02399; PubMed=15057824 [NCBI, ExPASy, EBI, Israel, Japan]
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[13]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Eye;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[14]
PROTEIN SEQUENCE OF 22-36 (ISOFORM 1).
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[15]
PARTIAL PROTEIN SEQUENCE, AND CHARACTERIZATION.
DOI=10.1016/0003-9861(91)90332-D; PubMed=1846736 [NCBI, ExPASy, EBI, Israel, Japan]
Nabeshima K., Lane W.S., Biswas C.;
"Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor.";
Arch. Biochem. Biophys. 285:90-96(1991).
[16]
REVIEW.
PubMed=12792908 [NCBI, ExPASy, EBI, Israel, Japan]
Muramatsu T., Miyauchi T.;
"Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion.";
Histol. Histopathol. 18:981-987(2003).
[17]
GLYCOSYLATION AT ASN-160 AND ASN-268.
DOI=10.1038/nbt827; PubMed=12754519 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang H., Li X.-J., Martin D.B., Aebersold R.;
"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.";
Nat. Biotechnol. 21:660-666(2003).
[18]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[19]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
DOI=10.1021/pr060363j; PubMed=17081065 [NCBI, ExPASy, EBI, Israel, Japan]
Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F.;
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.";
J. Proteome Res. 5:3135-3144(2006).
[20]
INTERACTION WITH AJAP1.
DOI=10.1091/mbc.E06-07-0637; PubMed=17267690 [NCBI, ExPASy, EBI, Israel, Japan]
Schreiner A., Ruonala M., Jakob V., Suthaus J., Boles E., Wouters F., Starzinski-Powitz A.;
"junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147.";
Mol. Biol. Cell 18:1272-1281(2007).
[21]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0611217104; PubMed=17287340 [NCBI, ExPASy, EBI, Israel, Japan]
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
[22]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
[23]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-268, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1021/pr8008012; PubMed=19159218 [NCBI, ExPASy, EBI, Israel, Japan]
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
[24]
VARIANT LYS-208.
DOI=10.1002/eji.1830270414; PubMed=9130641 [NCBI, ExPASy, EBI, Israel, Japan]
Spring F.A., Holmes C.H., Simpson K.L., Mawby W.J., Mattes M.J., Okubo Y., Parsons S.F.;
"The Ok(a) blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues.";
Eur. J. Immunol. 27:891-897(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X64364; CAA45716.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D45131; BAA08109.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L10240; AAA68936.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M87879; AAA91084.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L20471; AAB41120.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF042854; AAD10704.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF042848; AAD10704.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF042849; AAD10704.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF042850; AAD10704.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF042851; AAD10704.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF042852; AAD10704.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF042853; AAD10704.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB072923; BAB88938.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB085790; BAC76828.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF548371; AAN40694.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358113; AAQ88480.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY942196; AAX20110.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC005559; AAC33279.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009040; AAH09040.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00019906; -.
IPI00218019; -.
PIR A46506; A46506.
RefSeq NP_001719.2; -.
NP_940991.1; -.
UniGene Hs.591382
3D structure databases
PDB
3B5H; X-ray; 2.80 A; A/B/C/D=140-321.[ExPASy / RCSB / EBI]
PDBsum 3B5H; -.
ModBase P35613.
Protein-protein interaction databases
IntAct P35613; 4.
Protein family/group databases
TCDB 8.A.23.1.1; basigin family.
PTM databases
PhosphoSite P35613; -.
Enzyme and pathway databases
Pathway_Interaction_DB syndecan_1_pathway; Syndecan-1-mediated signaling events.
Reactome REACT_1046; Pyruvate metabolism and TCA cycle.
REACT_13552; Integrin cell surface interactions.
REACT_474; Metabolism of carbohydrates.
REACT_604; Hemostasis.
REACT_6900; Signaling in Immune system.
Organism-specific databases
GeneCards GC19P000522; -.
H-InvDB HIX0014556; -.
HGNC HGNC:1116; BSG.
GenAtlas BSG.
HPA CAB002427; -.
MIM 109480; gene. [NCBI / EBI]
111380; phenotype. [NCBI / EBI]
PharmGKB PA25433; -.
Gene expression databases
ArrayExpress P35613; -.
Bgee P35613; -.
CleanEx HS_BSG; -.
GermOnline ENSG00000172270; Homo sapiens.
Ontologies
GO
GO:0000139; Cellular component: Golgi membrane (inferred from experiment from Reactome).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0042470; Cellular component: melanosome (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005886; Cellular component: plasma membrane (inferred from experiment from Reactome).
GO:0005537; Molecular function: mannose binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0007166; Biological process: cell surface receptor linked signal transduction (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR013151; Ig.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 2.
Pfam PF00047; ig; 2.
Pfam graphical view of domain structure.
SMART SM00409; IG; 1.
SM00408; IGc2; 1.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 3.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P35613; -.
Genome annotation databases
Ensembl ENSG00000172270; Homo sapiens. [Contig view]
GeneID 682; -.
KEGG hsa:682; -.
Phylogenomic databases
HOGENOM P35613; -.
HOVERGEN P35613; -.
OMA P35613; DRNHLTR.
Other
NextBio 2802; -.
PMAP-CutDB P35613; -.
SOURCE BSG; Homo sapiens.
ProtoNet P35613.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Blood group antigen; Cell membrane; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Lectin; Mannose-binding; Membrane; Phosphoprotein; Polymorphism; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    21  21      
CHAIN   22   385  364     Basigin. PRO_0000014518
TOPO_DOM   138   323  186     Extracellular (Potential). 
TRANSMEM   324   344  21     Potential. 
TOPO_DOM   345   385  41     Cytoplasmic (Potential). 
DOMAIN   138   219  82     Ig-like C2-type. 
DOMAIN   221   315  95     Ig-like V-type. 
COMPBIAS   356   359  4     Poly-Asp. 
MOD_RES   362   362        Phosphoserine. 
MOD_RES   368   368        Phosphoserine. 
CARBOHYD   160   160        N-linked (GlcNAc...). 
CARBOHYD   268   268        N-linked (GlcNAc...). 
CARBOHYD   302   302        N-linked (GlcNAc...) (Potential). 
DISULFID   157   203        By similarity. 
DISULFID   242   301        By similarity. 
VAR_SEQ   24   139        Missing (in isoform 2). VSP_011501
VARIANT   208   208  1     E -> K (in Ok(A-)). VAR_013574 
VARIANT   269   269  1     G -> V (in dbSNP:rs1803203 [NCBI]). VAR_011720 
CONFLICT   328   328        F -> L (in Ref. 2; BAC76828). 
Sequence information
Length: 385 AA [This is the length of the unprocessed precursor] Molecular weight: 42200 Da [This is the MW of the unprocessed precursor] CRC64: D74C37455BF26685 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP VPEIQWWFEG 

        70         80         90        100        110        120 
QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE EDTGTYECRA SNDPDRNHLT 

       130        140        150        160        170        180 
RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG SKILLTCSLN DSATEVTGHR WLKGGVVLKE 

       190        200        210        220        230        240 
DALPGQKTEF KVDSDDQWGE YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML 

       250        260        270        280        290        300 
VCKSESVPPV TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR 

       310        320        330        340        350        360 
CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK PEDVLDDDDA 

       370        380 
GSAPLKSSGQ HQNDKGKNVR QRNSS 

P35613 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!