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UniProtKB/Swiss-Prot entry P35492


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HUTH_MOUSE
Primary accession number P35492
Secondary accession numbers None
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on June 1, 1994 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 63)
Name and origin of the protein
Protein name Histidine ammonia-lyase
Synonyms Histidase
EC 4.3.1.3
Gene name
Name: Hal
Synonyms: Hsd, Huth
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT HIS GLN-322.
STRAIN=C57BL/6J;
TISSUE=Liver;
DOI=10.1006/geno.1993.1164; PubMed=8486363 [NCBI, ExPASy, EBI, Israel, Japan]
Taylor R.G., Grieco D., Clarke G.A., McInnes R.R., Taylor B.A.;
"Identification of the mutation in murine histidinemia (his) and genetic mapping of the murine histidase locus (Hal) on chromosome 10.";
Genomics 16:231-240(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Skin;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1021/pr0604155; PubMed=17203969 [NCBI, ExPASy, EBI, Israel, Japan]
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.";
J. Proteome Res. 6:250-262(2007).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631; SER-635 AND SER-648, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1073/pnas.0609836104; PubMed=17242355 [NCBI, ExPASy, EBI, Israel, Japan]
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L07645; AAA37777.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK014518; BAB29407.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC057637; AAH57637.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A46128; A46128.
RefSeq NP_034531.1; -.
UniGene Mm.13000
3D structure databases
HSSP P21310; 1GKM. [HSSP ENTRY / PDB]
ModBase P35492.
PTM databases
PhosphoSite P35492; -.
Organism-specific databases
MGI MGI:96010; Hal.
Gene expression databases
ArrayExpress P35492; -.
CleanEx MM_HAL; -.
GermOnline ENSMUSG00000020017; Mus musculus.
Ontologies
GO
GO:0005625; Cellular component: soluble fraction (inferred from direct assay from MGI).
GO:0004397; Molecular function: histidine ammonia-lyase activity (inferred from direct assay from MGI).
GO:0006548; Biological process: histidine catabolic process (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR005921; HutH.
IPR001106; Phe/His_NH3-lyase.
Graphical view of domain structure.
Pfam PF00221; PAL; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01225; hutH; 1.
PROSITE PS00488; PAL_HISTIDASE; 1.
BLOCKS P35492.
Genome annotation databases
Ensembl ENSMUSG00000020017; Mus musculus. [Contig view]
GeneID 15109; -.
KEGG mmu:15109; -.
NMPDR fig|10090.3.peg.14273; -.
Phylogenomic databases
HOGENOM P35492; -.
HOVERGEN P35492; -.
Other
SOURCE Hal; Mus musculus.
ProtoNet P35492.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Disease mutation; Histidine metabolism; Lyase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   657  657     Histidine ammonia-lyase. PRO_0000161059
MOD_RES   254   254        2,3-didehydroalanine (Ser) (By similarity). 
MOD_RES   631   631        Phosphoserine. 
MOD_RES   635   635        Phosphoserine. 
MOD_RES   648   648        Phosphoserine. 
CROSSLNK   253   255        5-imidazolinone (Ala-Gly) (By similarity). 
VARIANT   322   322  1     R -> Q (in His; reduced stability). 
Sequence information
Length: 657 AA [This is the length of the unprocessed precursor] Molecular weight: 72258 Da [This is the MW of the unprocessed precursor] CRC64: 03402C348686C22D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPRYTVHVRG EWLAVPCQDG KLTVGWLGRE AVRRYMKNKP DNGGFTSVDE VQFLVHRCKG 

        70         80         90        100        110        120 
LGLLDNEDEL EVALEDNEFV EVVIEGDVMS PDFIPSQPEG VFLYSKYREP EKYIALDGDS 

       130        140        150        160        170        180 
LSTEDLVNLG KGRYKIKLTS IAEKKVQQSR EVIDSIIKER TVVYGITTGF GKFARTVIPA 

       190        200        210        220        230        240 
NKLQELQVNL VRSHSSGVGK PLSPERCRML LALRINVLAK GYSGISLETL KQVIEAFNAS 

       250        260        270        280        290        300 
CLSYVPEKGT VGASGDLAPL SHLALGLIGE GKMWSPKSGW ADAKYVLEAH GLKPIVLKPK 

       310        320        330        340        350        360 
EGLALINGTQ MITSLGCEAL ERASAIARQA DIVAALTLEV LKGTTKAFDT DIHAVRPHRG 

       370        380        390        400        410        420 
QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC PQVHGVVNDT IAFVKDIITT 

       430        440        450        460        470        480 
ELNSATDNPM VFASRGETIS GGNFHGEYPA KALDYLAIGV HELAAISERR IERLCNPSLS 

       490        500        510        520        530        540 
ELPAFLVAEG GLNSGFMIAH CTAAALVSES KALCHPSSVD SLSTSAATED HVSMGGWAAR 

       550        560        570        580        590        600 
KALRVVEHVE QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI 

       610        620        630        640        650 
EAAHRLLLDQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LESLRKNSAT IPESDDL 

P35492 in FASTA format

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