[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Sprague-Dawley; TISSUE=Lung; DOI=10.1016/S0005-2736(97)00065-5; PubMed=9218548 [NCBI, ExPASy, EBI, Israel, Japan] Gobl A.E., Huang M.R., Wang S., Zhou Y., Oeberg K.; "Molecular cloning and characterization of a cDNA encoding the rat interleukin-8 receptor."; Biochim. Biophys. Acta 1326:171-177(1997).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Wistar; TISSUE=Liver; Konishi K., Shibata F., Watanabe K., Tsurufuji S., Nakagawa H., Fujioka M.; Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Wistar; TISSUE=Lung, and Spleen; DOI=10.1074/jbc.271.51.32770; PubMed=8955112 [NCBI, ExPASy, EBI, Israel, Japan] Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L., Harrison J.K.; "Identification of two rat genes orthologous to the human interleukin-8 receptors."; J. Biol. Chem. 271:32770-32776(1996).

Comments

FUNCTION: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity.
INTERACTION:
Q9QYH1:Mpp4; NbExp=1; IntAct=EBI-937591, EBI-937554;
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
PTM: Phosphorylated upon ligand binding; which is required for desensitization (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X77797; CAA54824.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D63584; BAA09797.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U70988; AAC52961.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S42096; S42096.

NP_058879.1; -.

3D structure databases

ModBase

P35407.

Protein-protein interaction databases

IntAct

P35407; -.

Protein family/group databases

GPCRDB

P35407; CXCR2_RAT.

Organism-specific databases

RGD

2906; Il8rb.

Gene expression databases

ArrayExpress

P35407; -.

GermOnline

ENSRNOG00000014269; Rattus norvegicus.

Ontologies

GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.

Family and domain databases

InterPro

IPR001277; CXC_4_rcpt.
IPR000276; GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
IPR000174; IL8_rcpt.
IPR000057; IL8B_rcpt.
Graphical view of domain structure.

Pfam

PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00645; CXCCHMKINER4.
PR00237; GPCRRHODOPSN.
PR00427; INTRLEUKIN8R.
PR00573; INTRLEUKN8BR.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P35407.

Genome annotation databases

Ensembl

ENSRNOG00000014269; Rattus norvegicus. [Contig view]

GeneID

29385; -.

KEGG

rno:29385; -.

Phylogenomic databases

HOVERGEN

P35407; -.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Chemotaxis; G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; Receptor; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 359`	`359`	`High affinity interleukin-8 receptor B.`	`PRO_0000069342`
`TOPO_DOM`	`1 47`	`47`	`Extracellular (Potential).`
`TRANSMEM`	`48 74`	`27`	`1 (Potential).`
`TOPO_DOM`	`75 83`	`9`	`Cytoplasmic (Potential).`
`TRANSMEM`	`84 104`	`21`	`2 (Potential).`
`TOPO_DOM`	`105 119`	`15`	`Extracellular (Potential).`
`TRANSMEM`	`120 141`	`22`	`3 (Potential).`
`TOPO_DOM`	`142 162`	`21`	`Cytoplasmic (Potential).`
`TRANSMEM`	`163 182`	`20`	`4 (Potential).`
`TOPO_DOM`	`183 207`	`25`	`Extracellular (Potential).`
`TRANSMEM`	`208 230`	`23`	`5 (Potential).`
`TOPO_DOM`	`231 250`	`20`	`Cytoplasmic (Potential).`
`TRANSMEM`	`251 272`	`22`	`6 (Potential).`
`TOPO_DOM`	`273 296`	`24`	`Extracellular (Potential).`
`TRANSMEM`	`297 314`	`18`	`7 (Potential).`
`TOPO_DOM`	`315 359`	`45`	`Cytoplasmic (Potential).`
`MOD_RES`	`346 346`		`Phosphoserine (By similarity).`
`MOD_RES`	`350 350`		`Phosphoserine (By similarity).`
`MOD_RES`	`351 351`		`Phosphoserine (By similarity).`
`MOD_RES`	`352 352`		`Phosphoserine (By similarity).`
`CARBOHYD`	`8 8`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`23 23`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`201 201`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`202 202`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`118 195`		`By similarity.`

Sequence information

Length: 359 AA [This is the length of the unprocessed precursor]

Molecular weight: 40532 Da [This is the MW of the unprocessed precursor]

CRC64: EF547326A074ABDD [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGEIRVDNFS LEDFFSGDID SYNYSSDPPF TLSDAAPCPS ANLDINRYAV VVIYVLVTLL 

        70         80         90        100        110        120 
SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL PVWAASKVNG WIFGSFLCKV 

       130        140        150        160        170        180 
FSFLQEITFY SSVLLLACIS MDRYLAIVHA TSTLIQKRHL VKFVCITMWF LSLVLSLPIF 

       190        200        210        220        230        240 
ILRTTVKANP STVVCYENIG NNTSKWRVVL RILPQTYGFL LPLLIMLFCY GFTLRTLFKA 

       250        260        270        280        290        300 
HMGQKHRAMR VIFAVVLVFL LCWLPYNIVL FTDTLMRTKL IKETCERQNE INKALEATEI 

       310        320        330        340        350 
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAN YGLVSKEFLA KEGRPSFVGS SSANTSTTL

P35407 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools