ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P34972

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name CNR2_HUMAN
Primary accession number P34972
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1994
Sequence was last modified on February 1, 1994 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 75)
Name and origin of the protein
Protein name Cannabinoid receptor 2
Synonyms CB-2
CB2
CX5
Gene name
Name: CNR2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/365061a0; PubMed=7689702 [NCBI, ExPASy, EBI, Israel, Japan]
Munro S., Thomas K.L., Abu-Shaar M.;
"Molecular characterization of a peripheral receptor for cannabinoids.";
Nature 365:61-65(1993).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
Bruss M., Bonisch H.;
"The mRNA encoding the human cannabinoid CB2 receptor is expressed in embryonic kidney HEK293 cells.";
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Blood;
Bruss M., Bonisch H.;
"Cannabinoid receptors and their genes.";
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
[4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Warren C.N., Aronstam R.S., Sharma S.V.;
"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X74328; CAA52376.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ430063; CAD22548.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ430064; CAD22549.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY242132; AAO92299.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S36750; S36750.
RefSeq NP_001832.1; -.
UniGene Hs.73037
3D structure databases
ModBase P34972.
Protein family/group databases
GPCRDB P34972; CNR2_HUMAN.
PTM databases
PhosphoSite P34972; -.
Organism-specific databases
H-InvDB HIX0028631; -.
HGNC HGNC:2160; CNR2.
GenAtlas CNR2.
HPA CAB009719; -.
MIM 605051; gene. [NCBI / EBI]
PharmGKB PA26682; -.
GeneCards P34972.
Gene expression databases
ArrayExpress P34972; -.
CleanEx HS_CNR2; -.
GermOnline ENSG00000188822; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004949; Molecular function: cannabinoid receptor activity (traceable author statement from ProtInc).
GO:0007610; Biological process: behavior (traceable author statement from ProtInc).
GO:0007187; Biological process: G-protein signaling, coupled to cyclic nucleotide second messenger (traceable author statement from ProtInc).
GO:0006955; Biological process: immune response (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001551; Canbinoid_rcpt_2.
IPR002230; Cnbnoid_rcpt.
IPR000276; GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.
PANTHER PTHR22750:SF11; Canbinoid_rcpt_2; 1.
Pfam PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00523; CANABINOID2R.
PR00362; CANNABINOIDR.
PR00237; GPCRRHODOPSN.
PROSITE PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P34972.
Genome annotation databases
Ensembl ENSG00000188822; Homo sapiens. [Contig view]
GeneID 1269; -.
KEGG hsa:1269; -.
Phylogenomic databases
HOGENOM P34972; -.
HOVERGEN P34972; -.
Other
BindingDB P34972; -.
DrugBank DB00486; Nabilone.
SOURCE CNR2; Homo sapiens.
GPCRDB-Snakes P34972.
ProtoNet P34972.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   360  360     Cannabinoid receptor 2. PRO_0000069323
TOPO_DOM   1    33  33     Extracellular (Potential). 
TRANSMEM   34    59  26     1 (Potential). 
TOPO_DOM   60    71  12     Cytoplasmic (Potential). 
TRANSMEM   72    92  21     2 (Potential). 
TOPO_DOM   93   104  12     Extracellular (Potential). 
TRANSMEM   105   129  25     3 (Potential). 
TOPO_DOM   130   149  20     Cytoplasmic (Potential). 
TRANSMEM   150   172  23     4 (Potential). 
TOPO_DOM   173   188  16     Extracellular (Potential). 
TRANSMEM   189   214  26     5 (Potential). 
TOPO_DOM   215   246  32     Cytoplasmic (Potential). 
TRANSMEM   247   267  21     6 (Potential). 
TOPO_DOM   268   279  12     Extracellular (Potential). 
TRANSMEM   280   301  22     7 (Potential). 
TOPO_DOM   302   360  59     Cytoplasmic (Potential). 
CARBOHYD   11    11        N-linked (GlcNAc...) (Potential). 
VARIANT   316   316  1     H -> Y (in dbSNP:rs2229579 [NCBI]). VAR_029209 
Sequence information
Length: 360 AA [This is the length of the unprocessed precursor] Molecular weight: 39681 Da [This is the MW of the unprocessed precursor] CRC64: A7ECF68C16E7514B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEECWVTEIA NGSKDGLDSN PMKDYMILSG PQKTAVAVLC TLLGLLSALE NVAVLYLILS 

        70         80         90        100        110        120 
SHQLRRKPSY LFIGSLAGAD FLASVVFACS FVNFHVFHGV DSKAVFLLKI GSVTMTFTAS 

       130        140        150        160        170        180 
VGSLLLTAID RYLCLRYPPS YKALLTRGRA LVTLGIMWVL SALVSYLPLM GWTCCPRPCS 

       190        200        210        220        230        240 
ELFPLIPNDY LLSWLLFIAF LFSGIIYTYG HVLWKAHQHV ASLSGHQDRQ VPGMARMRLD 

       250        260        270        280        290        300 
VRLAKTLGLV LAVLLICWFP VLALMAHSLA TTLSDQVKKA FAFCSMLCLI NSMVNPVIYA 

       310        320        330        340        350        360 
LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP DSRDLDLSDC
P34972 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ch flag SIB Switzerland Mirror sites: Australia Brazil Canada China Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!