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UniProtKB/Swiss-Prot entry P34932


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HSP74_HUMAN
Primary accession number P34932
Secondary accession numbers O95756 Q2TAL4
Integrated into Swiss-Prot on February 1, 1994
Sequence was last modified on September 23, 2008 (Sequence version 4)
Annotations were last modified on    June 16, 2009 (Entry version 91)
Name and origin of the protein
Protein name Heat shock 70 kDa protein 4
Synonyms Heat shock 70-related protein APG-2
HSP70RY
Gene name
Name: HSPA4
Synonyms: APG2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Nonoguchi K., Fujita J.;
"Cloning and characterization of human apg-1 and apg-2, members of the hsp110 family, cDNAs and chromosomal assignment of the genes.";
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02919; PubMed=15372022 [NCBI, ExPASy, EBI, Israel, Japan]
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
"The DNA sequence and comparative analysis of human chromosome 5.";
Nature 431:268-274(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-749.
TISSUE=Lymphocyte;
PubMed=8335910 [NCBI, ExPASy, EBI, Israel, Japan]
Fathallah D.M., Cherif D., Dellagi K., Arnaout M.A.;
"Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5.";
J. Immunol. 151:810-813(1993).
[5]
PROTEIN SEQUENCE OF 20-33; 111-124; 170-185; 222-234; 333-346; 361-374 AND 391-422, AND MASS SPECTROMETRY.
TISSUE=Brain, Cajal-Retzius cell, and Fetal brain cortex;
Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.;
Submitted (DEC-2008) to UniProtKB.
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-89 AND TYR-336, AND MASS SPECTROMETRY.
DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan]
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
Nat. Biotechnol. 23:94-101(2005).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76 AND THR-538, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[9]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB023420; BAA75062.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC113410; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BC110861; AAI10862.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC126122; AAI26123.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC126124; AAI26125.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L12723; AAA02807.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00002966; -.
PIR I56208; I56208.
RefSeq NP_002145.3; -.
UniGene Hs.90093
3D structure databases
HSSP P19120; 1BA1. [HSSP ENTRY / PDB]
ModBase P34932.
Protein-protein interaction databases
IntAct P34932; 7.
PTM databases
PhosphoSite P34932; -.
2D gel databases
DOSAC-COBS-2DPAGE P34932; -.
REPRODUCTION-2DPAGE IPI00002966; -.
P34932; -.
Organism-specific databases
GeneCards GC05P132415; -.
H-InvDB HIX0005166; -.
HGNC HGNC:5237; HSPA4.
GenAtlas HSPA4.
HPA HPA010023; -.
MIM 601113; gene. [NCBI / EBI]
PharmGKB PA29503; -.
Gene expression databases
ArrayExpress P34932; -.
Bgee P34932; -.
CleanEx HS_HSPA4; -.
GermOnline ENSG00000170606; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (non-traceable author statement from UniProtKB).
GO:0005524; Molecular function: ATP binding (non-traceable author statement from UniProtKB).
GO:0034619; Biological process: cellular chaperone-mediated protein complex assembly (inferred from direct assay from UniProtKB).
GO:0070096; Biological process: mitochondrial outer membrane translocase complex assembly (inferred from direct assay from UniProtKB).
GO:0006986; Biological process: response to unfolded protein (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR018181; Heat_shock_70_CS.
IPR001023; Hsp70.
IPR013126; Hsp_70.
Graphical view of domain structure.
PANTHER PTHR19375; Hsp70; 1.
Pfam PF00012; HSP70; 2.
Pfam graphical view of domain structure.
PRINTS PR00301; HEATSHOCK70.
ProDom PD000089; Hsp70; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00297; HSP70_1; FALSE_NEG.
PS00329; HSP70_2; 1.
PS01036; HSP70_3; 1.
Proteomic databases
PRIDE P34932; -.
Genome annotation databases
Ensembl ENSG00000170606; Homo sapiens. [Contig view]
GeneID 3308; -.
KEGG hsa:3308; -.
Phylogenomic databases
HOGENOM P34932; -.
HOVERGEN P34932; -.
OMA P34932; QGDNPGP.
Other
NextBio 13119; -.
SOURCE HSPA4; Homo sapiens.
ProtoNet P34932.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Phosphoprotein; Stress response.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   840  840     Heat shock 70 kDa protein 4. PRO_0000078262
MOD_RES   76    76        Phosphoserine. 
MOD_RES   89    89        Phosphotyrosine. 
MOD_RES   336   336        Phosphotyrosine. 
MOD_RES   538   538        Phosphothreonine. 
MOD_RES   552   552        Phosphoserine. 
MOD_RES   660   660        Phosphotyrosine (By similarity). 
CONFLICT   94    94        L -> W (in Ref. 4; AAA02807). 
CONFLICT   190   190        A -> R (in Ref. 4; AAA02807). 
CONFLICT   583   586        NQLL -> ESAI (in Ref. 4; AAA02807). 
CONFLICT   622   622        E -> R (in Ref. 1; BAA75062). 
CONFLICT   644   644        D -> G (in Ref. 1; BAA75062). 
CONFLICT   746   749        NNKL -> EVTP (in Ref. 4; AAA02807). 
Sequence information
Length: 840 AA [This is the length of the unprocessed precursor] Molecular weight: 94331 Da [This is the MW of the unprocessed precursor] CRC64: 8B690A52A0729C2A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACIS FGPKNRSIGA AAKSQVISNA 

        70         80         90        100        110        120 
KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG IKVTYMEEER NFTTEQVTAM 

       130        140        150        160        170        180 
LLSKLKETAE SVLKKPVVDC VVSVPCFYTD AERRSVMDAT QIAGLNCLRL MNETTAVALA 

       190        200        210        220        230        240 
YGIYKQDLPA LEEKPRNVVF VDMGHSAYQV SVCAFNRGKL KVLATAFDTT LGGRKFDEVL 

       250        260        270        280        290        300 
VNHFCEEFGK KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDVDVSGT 

       310        320        330        340        350        360 
MNRGKFLEMC NDLLARVEPP LRSVLEQTKL KKEDIYAVEI VGGATRIPAV KEKISKFFGK 

       370        380        390        400        410        420 
ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY PISLRWNSPA EEGSSDCEVF 

       430        440        450        460        470        480 
SKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV 

       490        500        510        520        530        540 
KVRVNVHGIF SVSSASLVEV HKSEENEEPM ETDQNAKEEE KMQVDQEEPH VEEQQQQTPA 

       550        560        570        580        590        600 
ENKAESEEME TSQAGSKDKK MDQPPQAKKA KVKTSTVDLP IENQLLWQID REMLNLYIEN 

       610        620        630        640        650        660 
EGKMIMQDKL EKERNDAKNA VEEYVYEMRD KLSGEYEKFV SEDDRNSFTL KLEDTENWLY 

       670        680        690        700        710        720 
EDGEDQPKQV YVDKLAELKN LGQPIKIRFQ ESEERPKLFE ELGKQIQQYM KIISSFKNKE 

       730        740        750        760        770        780 
DQYDHLDAAD MTKVEKSTNE AMEWMNNKLN LQNKQSLTMD PVVKSKEIEA KIKELTSTCS 

       790        800        810        820        830        840 
PIISKPKPKV EPPKEEQKNA EQNGPVDGQG DNPGPQAAEQ GTDTAVPSDS DKKLPEMDID 

P34932 in FASTA format

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