[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Brain; PubMed=8391122 [NCBI, ExPASy, EBI, Israel, Japan] Hadingham K.L., Wingrove P., le Bourdelles B., Palmer K.J., Ragan C.I., Whiting P.J.; "Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors."; Mol. Pharmacol. 43:970-975(1993).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1002/(SICI)1096-8628(20000103)90:1<69::AID-AJMG12>3.3.CO;2-N; PubMed=10602120 [NCBI, ExPASy, EBI, Israel, Japan] Amir R., Dahle E.J., Toriolo D., Zoghbi H.Y.; "Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq."; Am. J. Med. Genet. 90:69-71(2000).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SUBUNIT: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) family [view classification].
WEB RESOURCE: Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http://www.expasy.org/spotlight/back_issues/sptlt056.shtml";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

S62908; AAB27279.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF166361; AAG12455.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF165901; AAG12455.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF165902; AAG12455.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF165903; AAG12455.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF165904; AAG12455.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF165905; AAG12455.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF165906; AAG12455.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF166359; AAG12455.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF166360; AAG12455.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC028629; AAH28629.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

I77911; I77911.

NP_000799.1; -.

3D structure databases

ModBase

P34903.

PTM databases

PhosphoSite

P34903; -.

Organism-specific databases

HIX0017117; -.

HGNC:4077; GABRA3.

HPA000839; -.

305660; gene. [NCBI / EBI]

PharmGKB

PA28491; -.

GeneCards

P34903.

Gene expression databases

ArrayExpress

P34903; -.

CleanEx

HS_GABRA3; -.

GermOnline

ENSG00000011677; Homo sapiens.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0008503;	Molecular function: benzodiazepine receptor activity (traceable author statement from ProtInc).
GO:0007214;	Biological process: gamma-aminobutyric acid signaling pathway (traceable author statement from ProtInc).
GO:0006810;	Biological process: transport (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR006028; GABAA_rcpt.
IPR001390; GABAAa_rcpt.
IPR005433; GABBAa3_rcpt.
IPR006029; Neu_channel_TM.
IPR006202; Neur_chan_lig_bd.
IPR006201; Neur_channel.
Graphical view of domain structure.

Gene3D

G3DSA:2.70.170.10; Neur_chan_lig_bd; 1.

PANTHER

PTHR18945; Neur_channel; 1.

Pfam

PF02931; Neur_chan_LBD; 1.
PF02932; Neur_chan_memb; 1.
Pfam graphical view of domain structure.

PRINTS

PR01079; GABAARALPHA.
PR01616; GABAARALPHA3.
PR00253; GABAARECEPTR.
PR00252; NRIONCHANNEL.

TIGRFAMs

TIGR00860; LIC; 1.

PROSITE

PS00236; NEUROTR_ION_CHANNEL; 1.

BLOCKS

P34903.

Genome annotation databases

Ensembl

ENSG00000011677; Homo sapiens. [Contig view]

GeneID

2556; -.

KEGG

hsa:2556; -.

Phylogenomic databases

HOGENOM

P34903; -.

HOVERGEN

P34903; -.

Other

DrugBank

DB00404; Alprazolam.
DB00829; Diazepam.
DB00189; Ethchlorvynol.
DB01544; Flunitrazepam.
DB00690; Flurazepam.
DB00186; Lorazepam.
DB00371; Meprobamate.
DB00683; Midazolam.

SOURCE

GABRA3; Homo sapiens.

ProtoNet

P34903.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell junction; Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion transport; Ionic channel; Membrane; Phosphoprotein; Postsynaptic cell membrane; Signal; Synapse; Transmembrane; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 28`	`28`	`Potential.`
`CHAIN`	`29 492`	`464`	`Gamma-aminobutyric acid receptor subunit alpha-3.`	`PRO_0000000437`
`TOPO_DOM`	`29 276`	`248`	`Extracellular (Probable).`
`TRANSMEM`	`277 298`	`22`	`Probable.`
`TRANSMEM`	`304 325`	`22`	`Probable.`
`TRANSMEM`	`338 359`	`22`	`Probable.`
`TOPO_DOM`	`360 457`	`98`	`Cytoplasmic (Probable).`
`TRANSMEM`	`458 479`	`22`	`Probable.`
`MOD_RES`	`433 433`		`Phosphoserine (By similarity).`
`CARBOHYD`	`63 63`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`163 163`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`176 176`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`228 228`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`191 205`		`By similarity.`
`CONFLICT`	`180 180`		`L -> P (in Ref. 3; AAH28629).`

Sequence information

Length: 492 AA [This is the length of the unprocessed precursor]

Molecular weight: 55165 Da [This is the MW of the unprocessed precursor]

CRC64: 23A7390C9822691F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MIITQTSHCY MTSLGILFLI NILPGTTGQG ESRRQEPGDF VKQDIGGLSP KHAPDIPDDS 

        70         80         90        100        110        120 
TDNITIFTRI LDRLLDGYDN RLRPGLGDAV TEVKTDIYVT SFGPVSDTDM EYTIDVFFRQ 

       130        140        150        160        170        180 
TWHDERLKFD GPMKILPLNN LLASKIWTPD TFFHNGKKSV AHNMTTPNKL LRLVDNGTLL 

       190        200        210        220        230        240 
YTMRLTIHAE CPMHLEDFPM DVHACPLKFG SYAYTTAEVV YSWTLGKNKS VEVAQDGSRL 

       250        260        270        280        290        300 
NQYDLLGHVV GTEIIRSSTG EYVVMTTHFH LKRKIGYFVI QTYLPCIMTV ILSQVSFWLN 

       310        320        330        340        350        360 
RESVPARTVF GVTTVLTMTT LSISARNSLP KVAYATAMDW FIAVCYAFVF SALIEFATVN 

       370        380        390        400        410        420 
YFTKRSWAWE GKKVPEALEM KKKTPAAPAK KTSTTFNIVG TTYPINLAKD TEFSTISKGA 

       430        440        450        460        470        480 
APSASSTPTI IASPKATYVQ DSPTETKTYN SVSKVDKISR IIFPVLFAIF NLVYWATYVN 

       490 
RESAIKGMIR KQ

P34903 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools