ID   DNLI_VARV               Reviewed;         552 AA.
AC   P33798; Q90028;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   04-NOV-2008, entry version 50.
DE   RecName: Full=DNA ligase;
DE            EC=6.5.1.1;
DE   AltName: Full=Polydeoxyribonucleotide synthase [ATP];
GN   Name=LIG; ORFNames=A50R, J4R;
OS   Variola virus.
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   MEDLINE=92209372; PubMed=1666548;
RA   Shchelkunov S.N., Marennikova S.S., Totmenin A.V., Blinov V.M.,
RA   Chizhikov V.E., Gutorov V.V., Safronov P.F., Pozdnyakov S.G.,
RA   Shelukhina E.M., Gashnikov P.V., Anjaparidze O.G., Sandakhchiev L.S.;
RT   "Creation of a clone library of fragments from the natural variola
RT   virus and study of the structural and functional organization of viral
RT   genes from a circle of hosts.";
RL   Dokl. Akad. Nauk SSSR 321:402-406(1991).
RN   [2]
RP   COMPLETE GENOME.
RC   STRAIN=India-1967 / Isolate Ind3;
RX   MEDLINE=93202281; PubMed=8384129; DOI=10.1016/0014-5793(93)80041-R;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Harvey;
RX   MEDLINE=93057361; PubMed=1331292;
RA   Aguado B., Selmes I.P., Smith G.L.;
RT   "Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey
RT   and comparison with vaccinia virus.";
RL   J. Gen. Virol. 73:2887-2902(1992).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   MEDLINE=94088747; PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R.,
RA   Knight J.C., Aubin L., Yuran T.E., Parsons J.M., Loparev V.N.,
RA   Selivanov N.A., Cavallaro K.F., Kerlavage A.R., Mahy B.W.J.,
RA   Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola
RT   smallpox virus genome.";
RL   Nature 366:748-751(1993).
CC   -!- FUNCTION: This protein seals, during DNA replication, DNA
CC       recombination and DNA repair, nicks in double-stranded DNA. It is
CC       not essential for viral replication and recombination.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) +
CC       (deoxyribonucleotide)(m) = AMP + diphosphate +
CC       (deoxyribonucleotide)(n+m).
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
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DR   EMBL; X69198; CAA49103.1; -; Genomic_DNA.
DR   EMBL; X67118; CAA47545.1; -; Genomic_DNA.
DR   EMBL; L22579; AAA60905.1; -; Genomic_DNA.
DR   PIR; C36854; JQ1857.
DR   PIR; T28595; T28595.
DR   RefSeq; NP_042206.1; -.
DR   GeneID; 1486450; -.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR000977; DNA_ligase.
DR   InterPro; IPR012309; DNA_ligase_A_C.
DR   InterPro; IPR012310; DNA_ligase_A_M.
DR   InterPro; IPR012308; DNA_ligase_A_N.
DR   InterPro; IPR016059; DNA_ligase_CS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; DNA damage; DNA recombination;
KW   DNA repair; DNA replication; Ligase; Nucleotide-binding.
FT   CHAIN         1    552       DNA ligase.
FT                                /FTId=PRO_0000059590.
FT   ACT_SITE    231    231       N6-AMP-lysine intermediate (By
FT                                similarity).
FT   CONFLICT    194    194       D -> N (in Ref. 4; AAA60905).
SQ   SEQUENCE   552 AA;  63382 MW;  618EDFB5B92FCE7D CRC64;
     MTSLREFRKL CCAIYHASGY KEKSKLIRDF ITDRDDKYLI IKLLLPGLDD RIYNMNDKQI
     IKIYSIIFKQ SQKDMLQDLG YGYIGDTIST FFKENTEIRP RNKSILTLED VDSFLTTLSS
     ITKESHQIKL LTDIASVCTC NDLKCVVMLI DKDLKIKAGP RYVLNAISPH AYDVFRKSNN
     LKEIIENESK QNLDSISVSV MTPINPMLAE SCDSVNKAFK KFPSGMFAEV KYDGERVQVH
     KNNNEFAFFS RNMKPVLSYK VDYLKEYIPK AFKKATSIVL DSEIVLVDEH NVQLPFGSLG
     IHKKKEYKNS NMCLFVFDCL YFDGFDMTDI PLYKRRSFLK DVMVEIPNRI VFSELTNISN
     ESQLTDVLDD ALTRKLEGLV LKDINGVYEP GKRRWLKIKR DYLNEGSMAD SADLVVLGAY
     YGKGAKGGIM AVFLMGCYDD ESGKWKTVTK CSGHDDNTLR VLQDQLTMVK INKDPKKIPE
     WLVVNKIYIP DFVVEDPKQS QIWEISGAEF TSSKSHTANG ISIRFPRFTR IREDKTWKES
     THLNDLVNLT KS
//