ID   IGF1_CANFA              Reviewed;         153 AA.
AC   P33712;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   22-JUL-2008, entry version 51.
DE   RecName: Full=Insulin-like growth factor I;
DE            Short=IGF-I;
DE   AltName: Full=Somatomedin;
DE   Flags: Precursor;
GN   Name=IGF1; Synonyms=IGFIA;
OS   Canis familiaris (Dog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Synovium;
RA   Staten N.R.;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 30-151.
RX   MEDLINE=93366192; PubMed=8359700; DOI=10.1016/0378-1119(93)90437-8;
RA   Delafontaine P., Lou H., Harrison D.G., Bernstein K.E.;
RT   "Sequence of a cDNA encoding dog insulin-like growth factor I.";
RL   Gene 130:305-306(1993).
RN   [3]
RP   POLYMORPHISM.
RX   PubMed=17412960; DOI=10.1126/science.1137045;
RA   Sutter N.B., Bustamante C.D., Chase K., Gray M.M., Zhao K., Zhu L.,
RA   Padhukasahasram B., Karlins E., Davis S., Jones P.G., Quignon P.,
RA   Johnson G.S., Parker H.G., Fretwell N., Mosher D.S., Lawler D.F.,
RA   Satyaraj E., Nordborg M., Lark K.G., Wayne R.K., Ostrander E.A.;
RT   "A single IGF1 allele is a major determinant of small size in dogs.";
RL   Science 316:112-115(2007).
CC   -!- FUNCTION: The insulin-like growth factors, isolated from plasma,
CC       are structurally and functionally related to insulin but have a
CC       much higher growth-promoting activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- POLYMORPHISM: The domestic dog exhibits greater diversity in body
CC       size than any other terrestrial vertebrate. A major quantitative
CC       trait locus (QTL) on chromosome 15 influences size variation
CC       within a single breed. In particular, a single-nucleotide
CC       polymorphism haplotype in IGF1 (synonymous SNP in exon 3) is
CC       common to all small breeds (less than 9 kg) and nearly absent from
CC       giant breeds (more than 30 kg), suggesting that the same causal
CC       sequence variant is a major contributor to body size in all small
CC       dogs.
CC   -!- SIMILARITY: Belongs to the insulin family.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=A dog's life - Issue 92
CC       of March 2008;
CC       URL="http://www.expasy.org/spotlight/back_issues/sptlt092.shtml";
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DR   EMBL; DN380306; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; L08254; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; PN0622; PN0622.
DR   RefSeq; XP_853117.1; -.
DR   HSSP; P01343; 2GF1.
DR   SMR; P33712; 20-89.
DR   Ensembl; ENSCAFG00000007304; Canis familiaris.
DR   GeneID; 610255; -.
DR   HOVERGEN; P33712; -.
DR   InterPro; IPR004825; Ins/IGF/relaxin.
DR   Gene3D; G3DSA:1.10.100.10; Ins/IGF/relaxin; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00276; INSULINA.
DR   PRINTS; PR00277; INSULINB.
DR   ProDom; PD001048; Bombyxin; 1.
DR   ProDom; PD015667; Mollusc_ins; 1.
DR   SMART; SM00078; IlGF; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   2: Evidence at transcript level;
KW   Growth factor; Secreted; Signal.
FT   SIGNAL        1      ?       Potential.
FT   PROPEP        ?     48       By similarity.
FT                                /FTId=PRO_0000330685.
FT   CHAIN        49    118       Insulin-like growth factor I.
FT                                /FTId=PRO_0000015650.
FT   PROPEP      119    153       E peptide.
FT                                /FTId=PRO_0000015651.
FT   REGION       49     77       B.
FT   REGION       78     89       C.
FT   REGION       90    110       A.
FT   REGION      111    118       D.
FT   DISULFID     54     96       By similarity.
FT   DISULFID     66    109       By similarity.
FT   DISULFID     95    100       By similarity.
FT   CONFLICT    150    153       NYRM -> TY (in Ref. 2; L08254).
SQ   SEQUENCE   153 AA;  16970 MW;  19D16DBF9151C0EF CRC64;
     MGKISSLPTQ LFKCCFCDFL KVKMHTVSSS HLFYLALCLL TFPSPATAGP ETLCGAELVD
     ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS
     VRAQRHTDMP KAQKEVHLKN ASRGSAGNKN YRM
//