ID   COMQ_BACSU              Reviewed;         299 AA.
AC   P33690;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   01-JUL-2008, entry version 55.
DE   Competence regulatory protein comQ.
GN   Name=comQ; OrderedLocusNames=BSU31710;
OS   Bacillus subtilis.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   MEDLINE=91358358; PubMed=1715859;
RA   Weinrauch Y., Msadek T., Kunst F., Dubnau D.;
RT   "Sequence and properties of comQ, a new competence regulatory gene of
RT   Bacillus subtilis.";
RL   J. Bacteriol. 173:5685-5693(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   MEDLINE=97419515; PubMed=9274030;
RA   Oudega B., Koningstein G., Rodrigues L., de Sales Ramon M.,
RA   Hilbert H., Duesterhoeft A., Pohl T.M., Weitzenegger T.;
RT   "Analysis of the Bacillus subtilis genome: cloning and nucleotide
RT   sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees
RT   (pai).";
RL   Microbiology 143:2769-2774(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA   Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA   Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA   Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA   Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA   Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA   Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA   Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA   Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA   Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA   Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA   Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA   Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA   Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA   Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA   Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA   Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA   Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA   Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA   Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA   Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA   Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   POLYMORPHISM IN COMX; COMQ AND COMP, AND FUNCTION.
RX   PubMed=11133937; DOI=10.1128/JB.183.2.451-460.2001;
RA   Tortosa P., Logsdon L., Kraigher B., Itoh Y., Mandic-Mulec I.,
RA   Dubnau D.;
RT   "Specificity and genetic polymorphism of the Bacillus competence
RT   quorum-sensing system.";
RL   J. Bacteriol. 183:451-460(2001).
CC   -!- FUNCTION: Involved in the maturation of comX, part of a major
CC       quorum-sensing system that regulates the development of genetic
CC       competence.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- MISCELLANEOUS: The DNA sequences encoding comQ, comX and the N-
CC       terminal two-thirds of comP show a striking polymorphism, which
CC       determines the specificity of the quorum-sensing system in the
CC       different pherotypes of Bacillus.
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DR   EMBL; M71283; AAA22323.1; -; Genomic_DNA.
DR   EMBL; Z93932; CAB07902.1; -; Genomic_DNA.
DR   EMBL; Z99120; CAB15159.1; -; Genomic_DNA.
DR   PIR; A38111; A38111.
DR   RefSeq; NP_391049.1; -.
DR   GeneID; 937180; -.
DR   GenomeReviews; AL009126_GR; BSU31710.
DR   KEGG; bsu:BSU31710; -.
DR   NMPDR; fig|224308.1.peg.3174; -.
DR   SubtiList; BG10379; comQ.
DR   HOGENOM; P33690; -.
DR   BioCyc; BSUB224308:BSU3166-MON; -.
DR   InterPro; IPR008949; Terpenoid_synth.
DR   Gene3D; G3DSA:1.10.600.10; Terpenoid_synth; 1.
PE   4: Predicted;
KW   Competence; Complete proteome; Membrane; Transmembrane.
FT   CHAIN         1    299       Competence regulatory protein comQ.
FT                                /FTId=PRO_0000090014.
FT   TRANSMEM    148    168       Potential.
SQ   SEQUENCE   299 AA;  34204 MW;  FC82ABB37D844BA8 CRC64;
     MKEIVEQNIF NEDLSQLLYS FIDSKETFSF AESSILHYVV FGGENLDVAT RLGAGIEILI
     LSSDIMDDLE DEDNHHALWM KINRSESLNA ALSLYTVGLT SIYSLNNNPL IFKYVLKYVN
     EAMQGQHDDI TNKSKTEDES LEVIRLKCGS LIALANVAGV LLATGEYNET VERYSYYKGI
     IAQISGDYYV LLSGNRSDIE KNKHTLIYLY LKRLFNDASE DLLYLISHKD LYYKSLLDKE
     KFQEKLIKAG VTQYISVLLE IYKQKCISAI EQLNLDKEKK ELIKECLLSY TKGDTRCKT
//