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UniProtKB/Swiss-Prot entry P33438


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GLT_DROME
Primary accession number P33438
Secondary accession numbers A4V0G5 Q9VLJ3
Integrated into Swiss-Prot on February 1, 1994
Sequence was last modified on March 1, 2004 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 70)
Name and origin of the protein
Protein name Glutactin [Precursor]
Synonyms None
Gene name
Name: Glt
ORFNames: CG9280
From
Drosophila melanogaster (Fruit fly) [TaxID: 7227] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, AND SULFATION.
STRAIN=Oregon-R;
PubMed=2108864 [NCBI, ExPASy, EBI, Israel, Japan]
Olson P.F., Fessler L.I., Nelson R.E., Sterne R.E., Campbell A.G., Fessler J.H.;
"Glutactin, a novel Drosophila basement membrane-related glycoprotein with sequence similarity to serine esterases.";
EMBO J. 9:1219-1227(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley;
TISSUE=Embryo;
PubMed=12537569 [NCBI, ExPASy, EBI, Israel, Japan]
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X53286; CAA37380.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014134; AAN10678.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014134; AAN10679.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY069776; AAL39921.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S12519; S12519.
RefSeq NP_477504.1; -.
NP_723408.1; -.
NP_723409.1; -.
UniGene Dm.14600
3D structure databases
HSSP P22303; 1F8U. [HSSP ENTRY / PDB]
ModBase P33438.
Enzyme and pathway databases
BioCyc DMEL-XXX-02:DMEL-XXX-02-008072-MON; -.
DMEL-XXX-02:DMEL-XXX-02-008073-MON; -.
DMEL-XXX-02:DMEL-XXX-02-008074-MON; -.
Organism-specific databases
FlyBase FBgn0001114; Glt.
Gene expression databases
ArrayExpress P33438; -.
GermOnline CG9280; Drosophila melanogaster.
Ontologies
GO
GO:0005604; Cellular component: basement membrane (inferred from direct assay from FlyBase).
QuickGo view.
Family and domain databases
InterPro IPR002018; CarbesteraseB.
Graphical view of domain structure.
PANTHER PTHR11559; CarbesteraseB; 1.
Pfam PF00135; COesterase; 1.
Pfam graphical view of domain structure.
PROSITE PS00941; CARBOXYLESTERASE_B_2; 1.
BLOCKS P33438.
Genome annotation databases
Ensembl CG9280; Drosophila melanogaster. [Contig view]
GeneID 34193; -.
KEGG dme:Dmel_CG9280; -.
Phylogenomic databases
HOGENOM P33438; -.
Other
ProtoNet P33438.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Basement membrane; Calcium; Complete proteome; Direct protein sequencing; Extracellular matrix; Glycoprotein; Secreted; Signal; Sulfation.
Features
SEVIEWER logo Feature table viewer
KeyFrom    To Length Description FTId
SIGNAL   1     17  17      
CHAIN   18   1026  1009     Glutactin. PRO_0000008639
COMPBIAS   595    615  21     Thr-rich. 
COMPBIAS   616   1026  411     Gln/Glu-rich. 
COMPBIAS   647    749  103     Arg-rich. 
MOD_RES   26     26        Sulfotyrosine (Potential). 
MOD_RES   29     29        Sulfotyrosine (Potential). 
MOD_RES   182    182        Sulfotyrosine (Potential). 
MOD_RES   559    559        Sulfotyrosine (Potential). 
MOD_RES   645    645        Sulfotyrosine (Potential). 
MOD_RES   727    727        Sulfotyrosine (Potential). 
MOD_RES   836    836        Sulfotyrosine (Potential). 
MOD_RES   862    862        Sulfotyrosine (Potential). 
MOD_RES   865    865        Sulfotyrosine (Potential). 
MOD_RES   868    868        Sulfotyrosine (Potential). 
MOD_RES   922    922        Sulfotyrosine (Potential). 
MOD_RES   928    928        Sulfotyrosine (Potential). 
MOD_RES   981    981        Sulfotyrosine (Potential). 
MOD_RES   984    984        Sulfotyrosine (Potential). 
MOD_RES   1006   1006        Sulfotyrosine (Potential). 
CARBOHYD   115    115        N-linked (GlcNAc...) (Potential). 
CARBOHYD   368    368        N-linked (GlcNAc...) (Potential). 
CARBOHYD   402    402        N-linked (GlcNAc...) (Potential). 
CARBOHYD   810    810        N-linked (GlcNAc...) (Potential). 
DISULFID   123    145        By similarity. 
DISULFID   298    316        By similarity. 
CONFLICT   919    921        Missing (in Ref. 1; CAA37380). 
CONFLICT   961    961        S -> L (in Ref. 1; CAA37380). 
Sequence information
Length: 1026 AA [This is the length of the unprocessed precursor] Molecular weight: 118749 Da [This is the MW of the unprocessed precursor] CRC64: EEB11216C4DC9DF6 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKPLLLVLAL CGAQVHAHSV GLRPDYNDYS DEDTRRDWLP EPLKPVPWQS ETRYAQPQEA 

        70         80         90        100        110        120 
VVQAPEVGQI LGISGHKTIA NRPVNAFLGI RYGTVGGGLA RFQAAQPIGY QGRVNATVQS 

       130        140        150        160        170        180 
PNCAQFPELD RLRLSESRGE NVDDCLTLDI YAPEGANQLP VLVFVHGEML FDGGSEEAQP 

       190        200        210        220        230        240 
DYVLEKDVLL VSINYRLAPF GFLSALTDEL PGNVALSDLQ LALEWLQRNV VHFGGNAGQV 

       250        260        270        280        290        300 
TLVGQAGGAT LAHALSLSGR AGNLFQQLIL QSGTALNPYL IDNQPLDTLS TFARLARCPP 

       310        320        330        340        350        360 
PSINPSAQGL KPLYDCLARL PTSQLVAAFE QLLLQNEHLG LTQLGGFKLV VGDPLGFLPS 

       370        380        390        400        410        420 
HPASLATNSS LALPMIIGAT KDASAFIVSR IYDQLARLQS RNVSDYIDVV LRHTAPPSEH 

       430        440        450        460        470        480 
RLWKQWALRE IFTPIQEQTA SLQTVAPGLL ELSNYILYRA PVINSISQSY RSVPAYLYTF 

       490        500        510        520        530        540 
DYRGEHHRFG HLSNPLPFGV DASLSDDSVY LFPYPPEASR LNPLDRSLSR ALVTMWVNFA 

       550        560        570        580        590        600 
TTGVPNPSSG VWPQATSEYG PFLRFTNNQQ SPLELDPHFG EGIYLPNYRV IYKPTTNFSP 

       610        620        630        640        650        660 
PITTTTTTTT TTTTTSRPYA YNPYANWQNR PSQQHPNWHP ADPEYVRAQE ARQQEFIRER 

       670        680        690        700        710        720 
EQRRREQQLR DQQRYPQQEP REQQDERIRQ QREQEERLRQ QREQEERLRQ QRELEERIRQ 

       730        740        750        760        770        780 
QQEREQYERE QQEREQRERE ELERQQRERE QQQPEQQPEY NPEPVNPWGY PVQEPQPDDN 

       790        800        810        820        830        840 
PEDGRLPYPS YEQYGPEGNE NLPETDANRN FSEEDREQQQ QEQLRREQQE QQEREYQLQL 

       850        860        870        880        890        900 
EREQQEREQQ ERGQQEPGPE EYPSYEEYSR ALQEKNAERD RIYAEEQERE RQQQETLLQE 

       910        920        930        940        950        960 
NQQHPEQSLP EEQPTHPNYE AYDGDRSYAE EQEREQQRRD QVEQEREEQP DEDQGEEYER 

       970        980        990       1000       1010       1020 
SPDEEEAAEQ DVLKVEDFPS YEAYLEAATK LREEQEEQEK LEEERYRAQQ EEEDRIQAER 


ERNSRN 

P33438 in FASTA format

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