[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 38626 / AH22 / NRRL Y-12843;
DOI=10.1007/BF00310491; PubMed=7882421 [NCBI, ExPASy, EBI, Israel, Japan]
Hirata D.,
Yano K.,
Miyahara K.,
Miyakawa T.;
"Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance.";
Curr. Genet. 26:285-294(1994).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, TOPOLOGY, AND DOMAINS.
STRAIN=ATCC 204508 / S288c;
PubMed=8294477 [NCBI, ExPASy, EBI, Israel, Japan]
Balzi E.,
Wang M.,
Leterme S.,
van Dyck L.,
Goffeau A.;
"PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.";
J. Biol. Chem. 269:2206-2214(1994).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204510 / AB320;
PubMed=8307980 [NCBI, ExPASy, EBI, Israel, Japan]
Bissinger P.H.,
Kuchler K.;
"Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance.";
J. Biol. Chem. 269:4180-4186(1994).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=S288c / FY1678;
DOI=10.1002/(SICI)1097-0061(199701)13:1<73::AID-YEA52>3.3.CO;2-D; PubMed=9046089 [NCBI, ExPASy, EBI, Israel, Japan]
Bordonne R.,
Camasses A.,
Madania A.,
Poch O.,
Tarassov I.A.,
Winsor B.,
Martin R.P.;
"Analysis of a 35.6 kb region on the right arm of Saccharomyces cerevisiae chromosome XV.";
Yeast 13:73-83(1997).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=S288c / FY1678;
PubMed=9169874 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B.,
Albermann K.,
Aldea M.,
Alexandraki D.,
Ansorge W.,
Arino J.,
Benes V.,
Bohn C.,
Bolotin-Fukuhara M.,
Bordonne R.,
Boyer J.,
Camasses A.,
Casamayor A.,
Casas C.,
Cheret G.,
Cziepluch C.,
Daignan-Fornier B.,
Dang V.-D.,
de Haan M., ![]()
Delius H.,
Durand P.,
Fairhead C.,
Feldmann H.,
Gaillon L.,
Galisson F.,
Gamo F.-J.,
Gancedo C.,
Goffeau A.,
Goulding S.E.,
Grivell L.A.,
Habbig B.,
Hand N.J.,
Hani J.,
Hattenhorst U.,
Hebling U.,
Hernando Y.,
Herrero E.,
Heumann K.,
Hiesel R.,
Hilger F.,
Hofmann B.,
Hollenberg C.P.,
Hughes B.,
Jauniaux J.-C.,
Kalogeropoulos A.,
Katsoulou C.,
Kordes E.,
Lafuente M.J.,
Landt O.,
Louis E.J.,
Maarse A.C.,
Madania A.,
Mannhaupt G.,
Marck C.,
Martin R.P.,
Mewes H.-W.,
Michaux G.,
Paces V.,
Parle-McDermott A.G.,
Pearson B.M.,
Perrin A.,
Pettersson B.,
Poch O.,
Pohl T.M.,
Poirey R.,
Portetelle D.,
Pujol A.,
Purnelle B.,
Ramezani Rad M.,
Rechmann S.,
Schwager C.,
Schweizer M.,
Sor F.,
Sterky F.,
Tarassov I.A.,
Teodoru C.,
Tettelin H.,
Thierry A.,
Tobiasch E.,
Tzermia M.,
Uhlen M.,
Unseld M.,
Valens M.,
Vandenbol M.,
Vetter I.,
Vlcek C.,
Voet M.,
Volckaert G.,
Voss H.,
Wambutt R.,
Wedler H.,
Wiemann S.,
Winsor B.,
Wolfe K.H.,
Zollner A.,
Zumstein E.,
Kleine K.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
Nature 387:98-102(1997).
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[6]
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TRANSCRIPTION REGULATION.
PubMed=3316228 [NCBI, ExPASy, EBI, Israel, Japan]
Balzi E.,
Chen W.,
Ulaszewski S.,
Capieaux E.,
Goffeau A.;
"The multidrug resistance gene PDR1 from Saccharomyces cerevisiae.";
J. Biol. Chem. 262:16871-16879(1987).
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[7]
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TRANSCRIPTION REGULATION.
DOI=10.1007/BF00351651; PubMed=1319843 [NCBI, ExPASy, EBI, Israel, Japan]
Meyers S.,
Schauer W.,
Balzi E.,
Wagner M.,
Goffeau A.,
Golin J.;
"Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5.";
Curr. Genet. 21:431-436(1992).
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[8]
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SUBSTRATES.
PubMed=7840595 [NCBI, ExPASy, EBI, Israel, Japan]
Leonard P.J.,
Rathod P.K.,
Golin J.;
"Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux.";
Antimicrob. Agents Chemother. 38:2492-2494(1994).
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[9]
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PURIFICATION, AND BIOPHYSICOCHEMICAL PROPERTIES.
PubMed=8175692 [NCBI, ExPASy, EBI, Israel, Japan]
Decottignies A.,
Kolaczkowski M.,
Balzi E.,
Goffeau A.;
"Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast.";
J. Biol. Chem. 269:12797-12803(1994).
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[10]
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TRANSCRIPTION REGULATION.
PubMed=8007969 [NCBI, ExPASy, EBI, Israel, Japan]
Katzmann D.J.,
Burnett P.E.,
Golin J.,
Mahe Y.,
Moye-Rowley W.S.;
"Transcriptional control of the yeast PDR5 gene by the PDR3 gene product.";
Mol. Cell. Biol. 14:4653-4661(1994).
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[11]
|
TRANSCRIPTION REGULATION.
PubMed=7623800 [NCBI, ExPASy, EBI, Israel, Japan]
Delahodde A.,
Delaveau T.,
Jacq C.;
"Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance.";
Mol. Cell. Biol. 15:4043-4051(1995).
|
[12]
|
DEGRADATION.
PubMed=7565740 [NCBI, ExPASy, EBI, Israel, Japan]
Egner R.,
Mahe Y.,
Pandjaitan R.,
Kuchler K.;
"Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae.";
Mol. Cell. Biol. 15:5879-5887(1995).
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[13]
|
FUNCTION.
PubMed=7753868 [NCBI, ExPASy, EBI, Israel, Japan]
Kralli A.,
Bohen S.P.,
Yamamoto K.R.;
"LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones.";
Proc. Natl. Acad. Sci. U.S.A. 92:4701-4705(1995).
|
[14]
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TRANSCRIPTION REGULATION.
DOI=10.1007/s002940050023; PubMed=8821655 [NCBI, ExPASy, EBI, Israel, Japan]
Miyahara K.,
Hirata D.,
Miyakawa T.;
"yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae.";
Curr. Genet. 29:103-105(1996).
|
[15]
|
DEGRADATION.
DOI=10.1016/0014-5793(95)01450-0; PubMed=8549828 [NCBI, ExPASy, EBI, Israel, Japan]
Egner R.,
Kuchler K.;
"The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole.";
FEBS Lett. 378:177-181(1996).
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[16]
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FUNCTION.
DOI=10.1016/S0014-5793(96)01353-1; PubMed=8985171 [NCBI, ExPASy, EBI, Israel, Japan]
Miyahara K.,
Mizunuma M.,
Hirata D.,
Tsuchiya E.,
Miyakawa T.;
"The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance.";
FEBS Lett. 399:317-320(1996).
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[17]
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INHIBITORS.
DOI=10.1074/jbc.271.29.17152; PubMed=8663352 [NCBI, ExPASy, EBI, Israel, Japan]
Kralli A.,
Yamamoto K.R.;
"An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones.";
J. Biol. Chem. 271:17152-17156(1996).
|
[18]
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FUNCTION.
DOI=10.1074/jbc.271.41.25167; PubMed=8810273 [NCBI, ExPASy, EBI, Israel, Japan]
Mahe Y.,
Lemoine Y.,
Kuchler K.;
"The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo.";
J. Biol. Chem. 271:25167-25172(1996).
|
[19]
|
FUNCTION.
DOI=10.1074/jbc.271.49.31543; PubMed=8940170 [NCBI, ExPASy, EBI, Israel, Japan]
Kolaczkowski M.,
van der Rest M.,
Cybularz-Kolaczkowska A.,
Soumillion J.P.,
Konings W.N.,
Goffeau A.;
"Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p.";
J. Biol. Chem. 271:31543-31548(1996).
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[20]
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SUBSTRATES.
DOI=10.1074/jbc.272.18.12091; PubMed=9115278 [NCBI, ExPASy, EBI, Israel, Japan]
Reid R.J.D.,
Kauh E.A.,
Bjornsti M.-A.;
"Camptothecin sensitivity is mediated by the pleiotropic drug resistance network in yeast.";
J. Biol. Chem. 272:12091-12099(1997).
|
[21]
|
TRANSCRIPTION REGULATION.
DOI=10.1007/s004380050583; PubMed=9393437 [NCBI, ExPASy, EBI, Israel, Japan]
Nourani A.,
Papajova D.,
Delahodde A.,
Jacq C.,
Subik J.;
"Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic drug resistance and identify a new central regulatory domain.";
Mol. Gen. Genet. 256:397-405(1997).
|
[22]
|
INDUCTION.
DOI=10.1007/s004380050584; PubMed=9393438 [NCBI, ExPASy, EBI, Israel, Japan]
Carvajal E.,
van den Hazel H.B.,
Cybularz-Kolaczkowska A.,
Balzi E.,
Goffeau A.;
"Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes.";
Mol. Gen. Genet. 256:406-415(1997).
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[23]
|
PROTEIN FAMILY.
DOI=10.1038/ng0297-137; PubMed=9020838 [NCBI, ExPASy, EBI, Israel, Japan]
Decottignies A.,
Goffeau A.;
"Complete inventory of the yeast ABC proteins.";
Nat. Genet. 15:137-145(1997).
|
[24]
|
SUBSTRATES.
PubMed=9559778 [NCBI, ExPASy, EBI, Israel, Japan]
Ogawa A.,
Hashida-Okado T.,
Endo M.,
Yoshioka H.,
Tsuruo T.,
Takesako K.,
Kato I.;
"Role of ABC transporters in aureobasidin A resistance.";
Antimicrob. Agents Chemother. 42:755-761(1998).
|
[25]
|
TRAFFICKING.
DOI=10.1074/jbc.273.49.32848; PubMed=9830032 [NCBI, ExPASy, EBI, Israel, Japan]
Plemper R.K.,
Egner R.,
Kuchler K.,
Wolf D.H.;
"Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome.";
J. Biol. Chem. 273:32848-32856(1998).
|
[26]
|
FUNCTION, AND MUTAGENESIS.
PubMed=9450972 [NCBI, ExPASy, EBI, Israel, Japan]
Egner R.,
Rosenthal F.E.,
Kralli A.,
Sanglard D.,
Kuchler K.;
"Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.";
Mol. Biol. Cell 9:523-543(1998).
|
[27]
|
FUNCTION.
PubMed=9818966 [NCBI, ExPASy, EBI, Israel, Japan]
Kolaczkowski M.,
Kolaczowska A.,
Luczynski J.,
Witek S.,
Goffeau A.;
"In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network.";
Microb. Drug Resist. 4:143-158(1998).
|
[28]
|
PHOSPHORYLATION BY CK1.
DOI=10.1074/jbc.274.52.37139; PubMed=10601275 [NCBI, ExPASy, EBI, Israel, Japan]
Decottignies A.,
Owsianik G.,
Ghislain M.;
"Casein kinase I-dependent phosphorylation and stability of the yeast multidrug transporter Pdr5p.";
J. Biol. Chem. 274:37139-37146(1999).
|
[29]
|
SUBSTRATES.
PubMed=10602734 [NCBI, ExPASy, EBI, Israel, Japan]
Golin J.,
Barkatt A.,
Cronin S.,
Eng G.,
May L.;
"Chemical specificity of the PDR5 multidrug resistance gene product of Saccharomyces cerevisiae based on studies with tri-n-alkyltin chlorides.";
Antimicrob. Agents Chemother. 44:134-138(2000).
|
[30]
|
SUBSTRATES.
DOI=10.1128/AAC.44.2.418-420.2000; PubMed=10639374 [NCBI, ExPASy, EBI, Israel, Japan]
Michalkova-Papajova D.,
Obernauerova M.,
Subik J.;
"Role of the PDR gene network in yeast susceptibility to the antifungal antibiotic mucidin.";
Antimicrob. Agents Chemother. 44:418-420(2000).
|
[31]
|
TOPOLOGY, AND MUTAGENESIS.
PubMed=10712705 [NCBI, ExPASy, EBI, Israel, Japan]
Egner R.,
Bauer B.E.,
Kuchler K.;
"The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility.";
Mol. Microbiol. 35:1255-1263(2000).
|
[32]
|
TRANSCRIPTION REGULATION.
DOI=10.1016/S0014-5793(00)01294-1; PubMed=10734226 [NCBI, ExPASy, EBI, Israel, Japan]
DeRisi J.,
van den Hazel B.,
Marc P.,
Balzi E.,
Brown P.,
Jacq C.,
Goffeau A.;
"Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants.";
FEBS Lett. 470:156-160(2000).
|
[33]
|
FUNCTION, AND INHIBITORS.
DOI=10.1021/bi000040f; PubMed=10841772 [NCBI, ExPASy, EBI, Israel, Japan]
Conseil G.,
Decottignies A.,
Jault J.-M.,
Comte G.,
Barron D.,
Goffeau A.,
Di Pietro A.;
"Prenyl-flavonoids as potent inhibitors of the Pdr5p multidrug ABC transporter from Saccharomyces cerevisiae.";
Biochemistry 39:6910-6917(2000).
|
[34]
|
INHIBITORS.
DOI=10.1021/bi002453m; PubMed=11327879 [NCBI, ExPASy, EBI, Israel, Japan]
Conseil G.,
Perez-Victoria J.M.,
Jault J.-M.,
Gamarro F.,
Goffeau A.,
Hofmann J.,
Di Pietro A.;
"Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity.";
Biochemistry 40:2564-2571(2001).
|
[35]
|
BIOTECHNOLOGY.
DOI=10.1271/bbb.65.1589; PubMed=11515543 [NCBI, ExPASy, EBI, Israel, Japan]
Hiraga K.,
Wanigasekera A.,
Sugi H.,
Hamanaka N.,
Oda K.;
"A novel screening for inhibitors of a pleiotropic drug resistant pump, Pdr5, in Saccharomyces cerevisiae.";
Biosci. Biotechnol. Biochem. 65:1589-1595(2001).
|
[36]
|
INHIBITORS.
DOI=10.1271/bbb.65.2353; PubMed=11758940 [NCBI, ExPASy, EBI, Israel, Japan]
Wanigasekera A.,
Hiraga K.,
Hamanaka N.,
Oda K.;
"Purification and some properties of an inhibitor for a yeast pleiotropic drug resistant pump from Kitasatospora sp. E-420.";
Biosci. Biotechnol. Biochem. 65:2353-2357(2001).
|
[37]
|
SUBSTRATES.
PubMed=11422371 [NCBI, ExPASy, EBI, Israel, Japan]
Hu W.,
Feng Q.,
Palli S.R.,
Krell P.J.,
Arif B.M.,
Retnakaran A.;
"The ABC transporter Pdr5p mediates the efflux of nonsteroidal ecdysone agonists in Saccharomyces cerevisiae.";
Eur. J. Biochem. 268:3416-3422(2001).
|
[38]
|
METABOLIC REGULATION.
DOI=10.1074/jbc.M106285200; PubMed=11602584 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang X.,
Moye-Rowley W.S.;
"Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase.";
J. Biol. Chem. 276:47844-47852(2001).
|
[39]
|
FUNCTION.
PubMed=11321575 [NCBI, ExPASy, EBI, Israel, Japan]
Rogers B.,
Decottignies A.,
Kolaczkowski M.,
Carvajal E.,
Balzi E.,
Goffeau A.;
"The pleitropic drug ABC transporters from Saccharomyces cerevisiae.";
J. Mol. Microbiol. Biotechnol. 3:207-214(2001).
|
[40]
|
TRANSCRIPTION REGULATION.
DOI=10.1074/jbc.M201637200; PubMed=11882665 [NCBI, ExPASy, EBI, Israel, Japan]
Hellauer K.,
Akache B.,
MacPherson S.,
Sirard E.,
Turcotte B.;
"Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter.";
J. Biol. Chem. 277:17671-17676(2002).
|
[41]
|
TRANSCRIPTION REGULATION.
DOI=10.1074/jbc.M202566200; PubMed=11943786 [NCBI, ExPASy, EBI, Israel, Japan]
Akache B.,
Turcotte B.;
"New regulators of drug sensitivity in the family of yeast zinc cluster proteins.";
J. Biol. Chem. 277:21254-21260(2002).
|
[42]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58 AND SER-61, AND MASS SPECTROMETRY.
DOI=10.1038/nbt0302-301; PubMed=11875433 [NCBI, ExPASy, EBI, Israel, Japan]
Ficarro S.B.,
McCleland M.L.,
Stukenberg P.T.,
Burke D.J.,
Ross M.M.,
Shabanowitz J.,
Hunt D.F.,
White F.M.;
"Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae.";
Nat. Biotechnol. 20:301-305(2002).
|
[43]
|
SUBCELLULAR LOCATION.
DOI=10.1002/1615-9861(200212)2:12<1706::AID-PROT1706>3.0.CO;2-K; PubMed=12469340 [NCBI, ExPASy, EBI, Israel, Japan]
Navarre C.,
Degand H.,
Bennett K.L.,
Crawford J.S.,
Moertz E.,
Boutry M.;
"Subproteomics: identification of plasma membrane proteins from the yeast Saccharomyces cerevisiae.";
Proteomics 2:1706-1714(2002).
|
[44]
|
FUNCTION, AND INHIBITORS.
DOI=10.1016/S0005-2736(03)00193-7; PubMed=12896805 [NCBI, ExPASy, EBI, Israel, Japan]
Conseil G.,
Perez-Victoria J.M.,
Renoir J.M.,
Goffeau A.,
Di Pietro A.;
"Potent competitive inhibition of drug binding to the Saccharomyces cerevisiae ABC exporter Pdr5p by the hydrophobic estradiol-derivative RU49953.";
Biochim. Biophys. Acta 1614:131-134(2003).
|
[45]
|
FUNCTION, AND INHIBITORS.
DOI=10.1016/S0924-8579(03)00214-0; PubMed=13678835 [NCBI, ExPASy, EBI, Israel, Japan]
Kolaczkowski M.,
Michalak K.,
Motohashi N.;
"Phenothiazines as potent modulators of yeast multidrug resistance.";
Int. J. Antimicrob. Agents 22:279-283(2003).
|
[46]
|
SUBSTRATES.
DOI=10.1074/jbc.M210908200; PubMed=12496287 [NCBI, ExPASy, EBI, Israel, Japan]
Golin J.,
Ambudkar S.V.,
Gottesman M.M.,
Habib A.D.,
Sczepanski J.,
Ziccardi W.,
May L.;
"Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux.";
J. Biol. Chem. 278:5963-5969(2003).
|
[47]
|
TRANSCRIPTION REGULATION.
DOI=10.1074/jbc.M208549200; PubMed=12529331 [NCBI, ExPASy, EBI, Israel, Japan]
Hikkel I.,
Lucau-Danila A.,
Delaveau T.,
Marc P.,
Devaux F.,
Jacq C.;
"A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast.";
J. Biol. Chem. 278:11427-11432(2003).
|
[48]
|
PURIFICATION, AND ELECTRON MICROSCOPY.
DOI=10.1074/jbc.M212198200; PubMed=12551908 [NCBI, ExPASy, EBI, Israel, Japan]
Ferreira-Pereira A.,
Marco S.,
Decottignies A.,
Nader J.,
Goffeau A.,
Rigaud J.L.;
"Three-dimensional reconstruction of the Saccharomyces cerevisiae multidrug resistance protein Pdr5p.";
J. Biol. Chem. 278:11995-11999(2003).
|
[49]
|
SUBSTRATES.
DOI=10.1074/jbc.M303300200; PubMed=12754197 [NCBI, ExPASy, EBI, Israel, Japan]
Gupta S.S.,
Ton V.-K.,
Beaudry V.,
Rulli S.,
Cunningham K.,
Rao R.;
"Antifungal activity of amiodarone is mediated by disruption of calcium homeostasis.";
J. Biol. Chem. 278:28831-28839(2003).
|
[50]
|
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S.,
Huh W.-K.,
Bower K.,
Howson R.W.,
Belle A.,
Dephoure N.,
O'Shea E.K.,
Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
|
[51]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-849; TYR-857 AND SER-863, UBIQUITINATION AT LYS-825, AND MASS SPECTROMETRY.
DOI=10.1038/nbt849; PubMed=12872131 [NCBI, ExPASy, EBI, Israel, Japan]
Peng J.,
Schwartz D.,
Elias J.E.,
Thoreen C.C.,
Cheng D.,
Marsischky G.,
Roelofs J.,
Finley D.,
Gygi S.P.;
"A proteomics approach to understanding protein ubiquitination.";
Nat. Biotechnol. 21:921-926(2003).
|
[52]
|
UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-825, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.2135500100; PubMed=14557538 [NCBI, ExPASy, EBI, Israel, Japan]
Hitchcock A.L.,
Auld K.,
Gygi S.P.,
Silver P.A.;
"A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.";
Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003).
|
[53]
|
BIOTECHNOLOGY.
DOI=10.1016/S0887-2333(03)00129-2; PubMed=14599467 [NCBI, ExPASy, EBI, Israel, Japan]
Lichtenberg-Frate H.,
Schmitt M.,
Gellert G.,
Ludwig J.;
"A yeast-based method for the detection of cyto and genotoxicity.";
Toxicol. in Vitro 17:709-716(2003).
|
[54]
|
BIOTECHNOLOGY.
DOI=10.1128/AAC.48.4.1256-1271.2004; PubMed=15047528 [NCBI, ExPASy, EBI, Israel, Japan]
Niimi K.,
Harding D.R.,
Parshot R.,
King A.,
Lun D.J.,
Decottignies A.,
Niimi M.,
Lin S.,
Cannon R.D.,
Goffeau A.,
Monk B.C.;
"Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative.";
Antimicrob. Agents Chemother. 48:1256-1271(2004).
|
[55]
|
SUBSTRATES.
DOI=10.1111/j.1432-1033.2004.04018.x; PubMed=15009193 [NCBI, ExPASy, EBI, Israel, Japan]
Wehrschutz-Sigl E.,
Jungwirth H.,
Bergler H.,
Hogenauer G.;
"The transporters Pdr5p and Snq2p mediate diazaborine resistance and are under the control of the gain-of-function allele PDR1-12.";
Eur. J. Biochem. 271:1145-1152(2004).
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[56]
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FUNCTION.
DOI=10.1016/S0014-5793(04)00046-8; PubMed=14960317 [NCBI, ExPASy, EBI, Israel, Japan]
Mamnun Y.M.,
Schuller C.,
Kuchler K.;
"Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase.";
FEBS Lett. 559:111-117(2004).
|
[57]
|
INDUCTION.
DOI=10.1074/jbc.M406363200; PubMed=15294907 [NCBI, ExPASy, EBI, Israel, Japan]
Gao C.,
Wang L.,
Milgrom E.,
Shen W.C.;
"On the mechanism of constitutive Pdr1 activator-mediated PDR5 transcription in Saccharomyces cerevisiae: evidence for enhanced recruitment of coactivators and altered nucleosome structures.";
J. Biol. Chem. 279:42677-42686(2004).
|
[58]
|
INHIBITORS.
DOI=10.1016/j.bbrc.2005.01.075; PubMed=15707993 [NCBI, ExPASy, EBI, Israel, Japan]
Hiraga K.,
Yamamoto S.,
Fukuda H.,
Hamanaka N.,
Oda K.;
"Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae.";
Biochem. Biophys. Res. Commun. 328:1119-1125(2005).
|
[59]
|
INHIBITORS.
DOI=10.1016/j.bbrc.2005.03.009; PubMed=15796929 [NCBI, ExPASy, EBI, Israel, Japan]
Yamamoto S.,
Hiraga K.,
Abiko A.,
Hamanaka N.,
Oda K.;
"A new function of isonitrile as an inhibitor of the Pdr5p multidrug ABC transporter in Saccharomyces cerevisiae.";
Biochem. Biophys. Res. Commun. 330:622-628(2005).
|
[60]
|
SUBSTRATES.
DOI=10.1021/bi0502994; PubMed=16008355 [NCBI, ExPASy, EBI, Israel, Japan]
Hanson L.,
May L.,
Tuma P.,
Keeven J.,
Mehl P.,
Ferenz M.,
Ambudkar S.V.,
Golin J.;
"The role of hydrogen bond acceptor groups in the interaction of substrates with Pdr5p, a major yeast drug transporter.";
Biochemistry 44:9703-9713(2005).
|
[61]
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METABOLIC REGULATION.
DOI=10.1016/j.gene.2005.03.019; PubMed=15896930 [NCBI, ExPASy, EBI, Israel, Japan]
Moye-Rowley W.S.;
"Retrograde regulation of multidrug resistance in Saccharomyces cerevisiae.";
Gene 354:15-21(2005).
|
[62]
|
FUNCTION, AND MUTAGENESIS.
DOI=10.1111/j.1365-2443.2005.00847.x; PubMed=15836770 [NCBI, ExPASy, EBI, Israel, Japan]
Tutulan-Cunita A.C.,
Mikoshi M.,
Mizunuma M.,
Hirata D.,
Miyakawa T.;
"Mutational analysis of the yeast multidrug resistance ABC transporter Pdr5p with altered drug specificity.";
Genes Cells 10:409-420(2005).
|
[63]
|
INDUCTION.
DOI=10.1016/j.biocel.2005.06.005; PubMed=16061415 [NCBI, ExPASy, EBI, Israel, Japan]
Malac J.,
Urbankova E.,
Sigler K.,
Gaskova D.;
"Activity of yeast multidrug resistance pumps during growth is controlled by carbon source and the composition of growth-depleted medium: DiS-C3(3) fluorescence assay.";
Int. J. Biochem. Cell Biol. 37:2536-2543(2005).
|
[64]
|
SUBSTRATES.
DOI=10.1074/jbc.M503147200; PubMed=16141212 [NCBI, ExPASy, EBI, Israel, Japan]
Sano T.,
Kihara A.,
Kurotsu F.,
Iwaki S.,
Igarashi Y.;
"Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants.";
J. Biol. Chem. 280:36674-36682(2005).
|
[65]
|
INDUCTION.
DOI=10.1128/MCB.25.5.1860-1868.2005; PubMed=15713640 [NCBI, ExPASy, EBI, Israel, Japan]
Lucau-Danila A.,
Lelandais G.,
Kozovska Z.,
Tanty V.,
Delaveau T.,
Devaux F.,
Jacq C.;
"Early expression of yeast genes affected by chemical stress.";
Mol. Cell. Biol. 25:1860-1868(2005).
|
[66]
|
INDUCTION.
DOI=10.1111/j.1567-1364.2006.00041.x; PubMed=16487346 [NCBI, ExPASy, EBI, Israel, Japan]
Teixeira M.C.,
Fernandes A.R.,
Mira N.P.,
Becker J.D.,
Sa-Correia I.;
"Early transcriptional response of Saccharomyces cerevisiae to stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid.";
FEMS Yeast Res. 6:230-248(2006).
|
[67]
|
INDUCTION.
DOI=10.1111/j.1567-1364.2006.00095.x; PubMed=17156010 [NCBI, ExPASy, EBI, Israel, Japan]
Alenquer M.,
Tenreiro S.,
Sa-Correia I.;
"Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinants TPO1 and PDR5.";
FEMS Yeast Res. 6:1130-1139(2006).
|
[68]
|
METABOLIC REGULATION, AND FUNCTION.
DOI=10.1534/genetics.106.057596; PubMed=16751665 [NCBI, ExPASy, EBI, Israel, Japan]
Souid A.K.,
Gao C.,
Wang L.,
Milgrom E.,
Shen W.C.;
"ELM1 is required for multidrug resistance in Saccharomyces cerevisiae.";
Genetics 173:1919-1937(2006).
|
[69]
|
TOPOLOGY [LARGE SCALE ANALYSIS].
DOI=10.1073/pnas.0604075103; PubMed=16847258 [NCBI, ExPASy, EBI, Israel, Japan]
Kim H.,
Melen K.,
Oesterberg M.,
von Heijne G.;
"A global topology map of the Saccharomyces cerevisiae membrane proteome.";
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
|
[70]
|
FUNCTION.
DOI=10.1016/j.bbrc.2007.02.011; PubMed=17316560 [NCBI, ExPASy, EBI, Israel, Japan]
Golin J.,
Ambudkar S.V.,
May L.;
"The yeast Pdr5p multidrug transporter: how does it recognize so many substrates?";
Biochem. Biophys. Res. Commun. 356:1-5(2007).
|
[71]
|
TRANSCRIPTION REGULATION.
DOI=10.1074/jbc.M610197200; PubMed=17158869 [NCBI, ExPASy, EBI, Israel, Japan]
Fardeau V.,
Lelandais G.,
Oldfield A.,
Salin H.,
Lemoine S.,
Garcia M.,
Tanty V.,
Le Crom S.,
Jacq C.,
Devaux F.;
"The central role of PDR1 in the foundation of yeast drug resistance.";
J. Biol. Chem. 282:5063-5074(2007).
|
[72]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-49; SER-54; SER-61; SER-837; SER-840; SER-841; SER-849; SER-850 AND SER-854, AND MASS SPECTROMETRY.
DOI=10.1021/pr060559j; PubMed=17330950 [NCBI, ExPASy, EBI, Israel, Japan]
Li X.,
Gerber S.A.,
Rudner A.D.,
Beausoleil S.A.,
Haas W.,
Villen J.,
Elias J.E.,
Gygi S.P.;
"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.";
J. Proteome Res. 6:1190-1197(2007).
|
[73]
|
TRAFFICKING.
DOI=10.1111/j.1365-2958.2006.05562.x; PubMed=17302805 [NCBI, ExPASy, EBI, Israel, Japan]
de Thozee C.P.,
Cronin S.,
Goj A.,
Golin J.,
Ghislain M.;
"Subcellular trafficking of the yeast plasma membrane ABC transporter, Pdr5, is impaired by a mutation in the N-terminal nucleotide-binding fold.";
Mol. Microbiol. 63:811-825(2007).
|
[74]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-837; SER-840 AND SER-841, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0607084104; PubMed=17287358 [NCBI, ExPASy, EBI, Israel, Japan]
Chi A.,
Huttenhower C.,
Geer L.Y.,
Coon J.J.,
Syka J.E.P.,
Bai D.L.,
Shabanowitz J.,
Burke D.J.,
Troyanskaya O.G.,
Hunt D.F.;
"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
|
[75]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-837; SER-840 AND SER-841, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0701622104; PubMed=17563356 [NCBI, ExPASy, EBI, Israel, Japan]
Smolka M.B.,
Albuquerque C.P.,
Chen S.H.,
Zhou H.;
"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.";
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
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