ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P33197

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name IDH_THET8
Primary accession number P33197
Secondary accession number Q5SI45
Integrated into Swiss-Prot on February 1, 1994
Sequence was last modified on March 29, 2005 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 59)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
OrderedLocusNames: TTHA1535
From
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [TaxID: 300852] [HAMAP proteome]
Taxonomy Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1539996 [NCBI, ExPASy, EBI, Israel, Japan]
Miyazaki K., Eguchi H., Yamagishi A., Wakagi T., Oshima T.;
"Molecular cloning of the isocitrate dehydrogenase gene of an extreme thermophile, Thermus thermophilus HB8.";
Appl. Environ. Microbiol. 58:93-98(1992).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
"Complete genome sequence of Thermus thermophilus HB8.";
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M94317; AAA27492.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP008226; BAD71358.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_144801.1; -.
3D structure databases
PDB
2D1C; X-ray; 1.80 A; A/B=1-496.[ExPASy / RCSB / EBI]
PDBsum 2D1C; -.
ModBase P33197.
Enzyme and pathway databases
BioCyc TTHE300852:TTHA1535-MON; -.
Family and domain databases
InterPro IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS P33197.
Genome annotation databases
GeneID 3168917; -.
GenomeReviews AP008226_GR; TTHA1535.
KEGG ttj:TTHA1535; -.
NMPDR fig|300852.3.peg.1847; -.
Phylogenomic databases
HOGENOM P33197; -.
Genome annotation databases
CMR P33197; TTHA1535.
Other
ProtoNet P33197.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Complete proteome; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   496  496     Isocitrate dehydrogenase [NADP]. PRO_0000083571
METAL   224   224        Magnesium or manganese (By similarity). 
METAL   248   248        Magnesium or manganese (By similarity). 
METAL   252   252        Magnesium or manganese (By similarity). 
BINDING   104   104        Substrate (By similarity). 
BINDING   114   114        Substrate (By similarity). 
BINDING   137   137        Substrate (By similarity). 
BINDING   224   224        Substrate (By similarity). 
SITE   144   144  1     Critical for catalysis (By similarity). 
SITE   191   191  1     Critical for catalysis (By similarity). 
MOD_RES   98    98        Phosphoserine (By similarity). 
CONFLICT   201   202        TL -> P (in Ref. 1; AAA27492). 
STRAND   3     5  3      
STRAND   11    14  4      
STRAND   20    25  6      
HELIX   31    44  14      
STRAND   49    53  5      
HELIX   58    61  4      
TURN   62    64  3      
HELIX   71    80  10      
STRAND   82    85  4      
STRAND   92    96  5      
HELIX   99   106  8      
STRAND   111   117  7      
TURN   125   128  4      
STRAND   132   138  7      
STRAND   140   142  3      
HELIX   143   145  3      
STRAND   148   152  5      
STRAND   155   163  9      
HELIX   164   180  17      
STRAND   185   190  6      
TURN   192   194  3      
HELIX   198   210  13      
STRAND   216   222  7      
HELIX   223   232  10      
HELIX   234   236  3      
STRAND   238   242  5      
HELIX   244   255  12      
TURN   256   259  4      
HELIX   261   263  3      
STRAND   265   269  5      
STRAND   274   280  7      
TURN   284   288  5      
HELIX   295   307  13      
HELIX   311   327  17      
HELIX   333   336  4      
TURN   338   340  3      
HELIX   344   353  10      
TURN   354   356  3      
STRAND   360   362  3      
HELIX   375   377  3      
STRAND   387   397  11      
HELIX   402   413  12      
STRAND   416   425  10      
STRAND   428   432  5      
STRAND   442   450  9      
STRAND   452   454  3      
HELIX   458   469  12      
STRAND   472   483  12      
STRAND   486   489  4      
Sequence information
Length: 496 AA [This is the length of the unprocessed precursor] Molecular weight: 54439 Da [This is the MW of the unprocessed precursor] CRC64: BF544C3F772E1AE9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPLITTETGK KMHVLEDGRK LITVIPGDGI GPECVEATLK VLEAAKAPLA YEVREAGASV 

        70         80         90        100        110        120 
FRRGIASGVP QETIESIRKT RVVLKGPLET PVGYGEKSAN VTLRKLFETY ANVRPVREFP 

       130        140        150        160        170        180 
NVPTPYAGRG IDLVVVRENV EDLYAGIEHM QTPSVAQTLK LISWKGSEKI VRFAFELARA 

       190        200        210        220        230        240 
EGRKKVHCAT KSNIMKLAEG TLKRAFEQVA QEYPDIEAVH IIVDNAAHQL VKRPEQFEVI 

       250        260        270        280        290        300 
VTTNMNGDIL SDLTSGLIGG LGFAPSANIG NEVAIFEAVH GSAPKYAGKN VINPTAVLLS 

       310        320        330        340        350        360 
AVMMLRYLEE FATADLIENA LLYTLEEGRV LTGDVVGYDR GAKTTEYTEA IIQNLGKTPR 

       370        380        390        400        410        420 
KTQVRGYKPF RLPQVDGAIA PIVPRSRRVV GVDVFVETNL LPEALGKALE DLAAGTPFRL 

       430        440        450        460        470        480 
KMISNRGTQV YPPTGGLTDL VDHYRCRFLY TGEGEAKDPE ILDLVSRVAS RFRWMHLEKL 

       490 
QEFDGEPGFT KAQGED
P33197 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ch flag SIB Switzerland Mirror sites: Australia Brazil Canada China Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!