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UniProtKB/Swiss-Prot entry P33176


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KINH_HUMAN
Primary accession number P33176
Secondary accession numbers A0AVB2 Q5VZ85
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on October 1, 1993 (Sequence version 1)
Annotations were last modified on    June 10, 2008 (Entry version 79)
Name and origin of the protein
Protein name Kinesin-1 heavy chain
Synonyms Ubiquitous kinesin heavy chain
UKHC
Conventional kinesin heavy chain
Gene name
Name: KIF5B
Synonyms: KNS, KNS1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
DOI=10.1083/jcb.117.6.1263; PubMed=1607388 [NCBI, ExPASy, EBI, Israel, Japan]
Navone F., Niclas J., Hom-Booher N., Sparks L., Bernstein H.D., McCaffrey G., Vale R.D.;
"Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells.";
J. Cell Biol. 117:1263-1275(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02462; PubMed=15164054 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INTERACTION WITH SYBU.
DOI=10.1038/ncb1169; PubMed=15459722 [NCBI, ExPASy, EBI, Israel, Japan]
Su Q., Cai Q., Gerwin C., Smith C.L., Sheng Z.-H.;
"Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons.";
Nat. Cell Biol. 6:941-953(2004).
[5]
INTERACTION WITH JAKMIP1.
DOI=10.1016/j.mcn.2007.04.008; PubMed=17532644 [NCBI, ExPASy, EBI, Israel, Japan]
Vidal R.L., Ramirez O.A., Sandoval L., Koenig-Robert R., Haertel S., Couve A.;
"Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport.";
Mol. Cell. Neurosci. 35:501-512(2007).
[6]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1-349.
DOI=10.1038/380550a0; PubMed=8606779 [NCBI, ExPASy, EBI, Israel, Japan]
Kull F.J., Sablin E.P., Lau R., Fletterick R.J., Vale R.D.;
"Crystal structure of the kinesin motor domain reveals a structural similarity to myosin.";
Nature 380:550-555(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X65873; CAA46703.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL161932; CAH71618.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC126279; AAI26280.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC126281; AAI26282.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A41919; A41919.
RefSeq NP_004512.1; -.
UniGene Hs.644646
3D structure databases
PDB
1BG2; X-ray; 1.80 A; A=1-325.[ExPASy / RCSB / EBI]
1MKJ; X-ray; 2.70 A; A=1-349.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1BG2; -.
1MKJ; -.
ModBase P33176.
Protein-protein interaction databases
IntAct P33176; -.
PTM databases
PhosphoSite P33176; -.
Organism-specific databases
H-InvDB HIX0035368; -.
HGNC HGNC:6324; KIF5B.
GeneLynx KIF5B; Homo sapiens.
GenAtlas KIF5B.
MIM 602809; gene. [NCBI / EBI]
PharmGKB PA30108; -.
GeneCards P33176.
Gene expression databases
ArrayExpress P33176; -.
CleanEx HS_KIF5B; -.
GermOnline ENSG00000170759; Homo sapiens.
Ontologies
GO
GO:0005871; Cellular component: kinesin complex (traceable author statement from ProtInc).
GO:0048471; Cellular component: perinuclear region of cytoplasm (inferred from sequence or structural similarity from HGNC).
GO:0008017; Molecular function: microtubule binding (inferred from sequence or structural similarity from HGNC).
GO:0003777; Molecular function: microtubule motor activity (inferred from sequence or structural similarity from HGNC).
GO:0047496; Biological process: vesicle transport along microtubule (inferred from sequence or structural similarity from HGNC).
QuickGo view.
Family and domain databases
InterPro IPR001752; Kinesin_motor.
Graphical view of domain structure.
Gene3D G3DSA:3.40.850.10; kinesin_motor; 1.
Pfam PF00225; Kinesin; 1.
Pfam graphical view of domain structure.
PRINTS PR00380; KINESINHEAVY.
SMART SM00129; KISc; 1.
SMART graphical view of domain structure.
PROSITE PS00411; KINESIN_MOTOR_DOMAIN1; 1.
PS50067; KINESIN_MOTOR_DOMAIN2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P33176.
Genome annotation databases
Ensembl ENSG00000170759; Homo sapiens. [Contig view]
GeneID 3799; -.
KEGG hsa:3799; -.
Phylogenomic databases
HOGENOM P33176; -.
HOVERGEN P33176; -.
Other
LinkHub P33176; -.
SOURCE KIF5B; Homo sapiens.
ProtoNet P33176.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; ATP-binding; Coiled coil; Microtubule; Motor protein; Nucleotide-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   963  963     Kinesin-1 heavy chain. PRO_0000125351
DOMAIN   1   328  328     Kinesin-motor. 
NP_BIND   85    92  8     ATP (By similarity). 
REGION   915   963  49     Globular. 
COILED   329   914  586      
STRAND   8    15  8      
HELIX   20    25  6      
STRAND   32    34  3      
TURN   35    37  3      
STRAND   38    41  4      
STRAND   44    47  4      
STRAND   49    52  4      
HELIX   58    65  8      
HELIX   67    74  8      
STRAND   79    84  6      
HELIX   91    95  5      
TURN   102   104  3      
HELIX   107   122  16      
STRAND   124   138  15      
STRAND   141   146  6      
STRAND   155   157  3      
STRAND   163   165  3      
STRAND   171   173  3      
HELIX   176   189  14      
TURN   190   193  4      
HELIX   197   203  7      
STRAND   204   216  13      
TURN   217   219  3      
STRAND   222   231  10      
STRAND   242   244  3      
HELIX   256   269  14      
HELIX   277   279  3      
HELIX   281   285  5      
HELIX   286   288  3      
STRAND   290   293  4      
STRAND   295   302  8      
HELIX   306   308  3      
HELIX   309   320  12      
STRAND   326   329  4      
HELIX   337   348  12      
Sequence information
Length: 963 AA [This is the length of the unprocessed precursor] Molecular weight: 109685 Da [This is the MW of the unprocessed precursor] CRC64: A1FE5760C3250C8B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MADLAECNIK VMCRFRPLNE SEVNRGDKYI AKFQGEDTVV IASKPYAFDR VFQSSTSQEQ 

        70         80         90        100        110        120 
VYNDCAKKIV KDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPEGMGIIPR IVQDIFNYIY 

       130        140        150        160        170        180 
SMDENLEFHI KVSYFEIYLD KIRDLLDVSK TNLSVHEDKN RVPYVKGCTE RFVCSPDEVM 

       190        200        210        220        230        240 
DTIDEGKSNR HVAVTNMNEH SSRSHSIFLI NVKQENTQTE QKLSGKLYLV DLAGSEKVSK 

       250        260        270        280        290        300 
TGAEGAVLDE AKNINKSLSA LGNVISALAE GSTYVPYRDS KMTRILQDSL GGNCRTTIVI 

       310        320        330        340        350        360 
CCSPSSYNES ETKSTLLFGQ RAKTIKNTVC VNVELTAEQW KKKYEKEKEK NKILRNTIQW 

       370        380        390        400        410        420 
LENELNRWRN GETVPIDEQF DKEKANLEAF TVDKDITLTN DKPATAIGVI GNFTDAERRK 

       430        440        450        460        470        480 
CEEEIAKLYK QLDDKDEEIN QQSQLVEKLK TQMLDQEELL ASTRRDQDNM QAELNRLQAE 

       490        500        510        520        530        540 
NDASKEEVKE VLQALEELAV NYDQKSQEVE DKTKEYELLS DELNQKSATL ASIDAELQKL 

       550        560        570        580        590        600 
KEMTNHQKKR AAEMMASLLK DLAEIGIAVG NNDVKQPEGT GMIDEEFTVA RLYISKMKSE 

       610        620        630        640        650        660 
VKTMVKRCKQ LESTQTESNK KMEENEKELA ACQLRISQHE AKIKSLTEYL QNVEQKKRQL 

       670        680        690        700        710        720 
EESVDALSEE LVQLRAQEKV HEMEKEHLNK VQTANEVKQA VEQQIQSHRE THQKQISSLR 

       730        740        750        760        770        780 
DEVEAKAKLI TDLQDQNQKM MLEQERLRVE HEKLKATDQE KSRKLHELTV MQDRREQARQ 

       790        800        810        820        830        840 
DLKGLEETVA KELQTLHNLR KLFVQDLATR VKKSAEIDSD DTGGSAAQKQ KISFLENNLE 

       850        860        870        880        890        900 
QLTKVHKQLV RDNADLRCEL PKLEKRLRAT AERVKALESA LKEAKENASR DRKRYQQEVD 

       910        920        930        940        950        960 
RIKEAVRSKN MARRGHSAQI AKPIRPGQHP AASPTHPSAI RGGGAFVQNS QPVAVRGGGG 


KQV 

P33176 in FASTA format

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View entry in raw text format (no links)
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