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UniProtKB/Swiss-Prot entry P33051


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NTP2_VARV
Primary accession number P33051
Secondary accession numbers Q85378 Q89208 Q9QNJ4
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on October 1, 1993 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name Nucleoside triphosphatase II
Synonyms NTPase II
EC 3.6.1.15
Nucleoside triphosphate phosphohydrolase II
NPH II
RNA helicase I8
Gene name
Name: NPH2
ORFNames: I8R, K8R, L8R
From
Variola virus [TaxID: 10255] 
Taxonomy Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
Virus host Homo sapiens (Human) [TaxID: 9606]
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=India-1967 / Isolate Ind3;
DOI=10.1016/0168-1702(93)90093-3; PubMed=8109158 [NCBI, ExPASy, EBI, Israel, Japan]
Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V., Sandakhchiev L.S.;
"Analysis of the nucleotide sequence of a 43 kbp segment of the genome of variola virus India-1967 strain.";
Virus Res. 30:239-258(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=India-1967 / Isolate Ind3;
DOI=10.1016/0168-1702(93)90110-9; PubMed=8383392 [NCBI, ExPASy, EBI, Israel, Japan]
Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S., Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gytorov V.V., Gashikov P.V., Belanov E.F., Belavin P.A., Resenchuk S.M., Andzhaparidze O.G., Sandakhchiev L.S.;
"Nucleotide sequence analysis of variola virus HindIII M, L, I genome fragments.";
Virus Res. 27:25-35(1993).
[3]
COMPLETE GENOME.
STRAIN=India-1967 / Isolate Ind3;
Blinov V.M.;
Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Bangladesh-1975;
DOI=10.1038/366748a0; PubMed=8264798 [NCBI, ExPASy, EBI, Israel, Japan]
Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C., Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A., Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
"Potential virulence determinants in terminal regions of variola smallpox virus genome.";
Nature 366:748-751(1993).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Garcia-1966;
DOI=10.1006/viro.1999.0086; PubMed=10639322 [NCBI, ExPASy, EBI, Israel, Japan]
Shchelkunov S.N., Totmenin A.V., Loparev V.N., Safronov P.F., Gutorov V.V., Chizhikov V.E., Knight J.C., Parsons J.M., Massung R.F., Esposito J.J.;
"Alastrim smallpox variola minor virus genome DNA sequences.";
Virology 266:361-386(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X67119; CAA47562.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X69198; CAA49003.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L22579; AAA60810.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y16780; CAB54662.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X76267; CAA53867.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D72158; D72158.
F36843; F36843.
T28500; T28500.
RefSeq NP_042106.1; -.
3D structure databases
ModBase P33051.
Family and domain databases
InterPro IPR003593; AAA+_ATPase_core.
IPR014001; DEAD-like_N.
IPR001650; DNA/RNA_helicase_C.
IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
IPR002464; DNA/RNA_helicase_DEAH_CS.
IPR014021; Helicase_SF1/SF2_ATP-bd.
Graphical view of domain structure.
Pfam PF00270; DEAD; 1.
PF00271; Helicase_C; 1.
Pfam graphical view of domain structure.
SMART SM00382; AAA; 1.
SM00487; DEXDc; 1.
SM00490; HELICc; 1.
SMART graphical view of domain structure.
PROSITE PS00690; DEAH_ATP_HELICASE; 1.
PS51192; HELICASE_ATP_BIND_1; 1.
PS51194; HELICASE_CTER; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P33051.
Genome annotation databases
GeneID 1486463; -.
Other
ProtoNet P33051.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Transcription.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   676  676     Nucleoside triphosphatase II. PRO_0000055186
DOMAIN   172   347  176     Helicase ATP-binding. 
DOMAIN   366   542  177     Helicase C-terminal. 
NP_BIND   185   192  8     ATP (By similarity). 
MOTIF   296   299  4     DEXH box. 
VARIANT   33    33  1     M -> T (in strain: Garcia-1966). 
VARIANT   147   147  1     G -> A (in strain: Garcia-1966). 
VARIANT   450   450  1     A -> T (in strain: Bangladesh-1975 and Garcia-1966). 
VARIANT   595   595  1     E -> K (in strain: Garcia-1966). 
VARIANT   632   632  1     D -> DNDNDND (in strain: Garcia-1966). 
Sequence information
Length: 676 AA [This is the length of the unprocessed precursor] Molecular weight: 77545 Da [This is the MW of the unprocessed precursor] CRC64: 4D7589E5B012562F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEKNLPDIFF FPNCVNVFSY KYSQDEFSNM SNMERDSFSL AVFPVIKHRW HNAHVVKHKG 

        70         80         90        100        110        120 
IYKVSTEAHG KKVSPPSLGK PSHINLTAKQ YIYSEHTISF ECYSFLKCIT NAEINSFDEY 

       130        140        150        160        170        180 
ILRGLLEAGN SLQIFSNSVG KRTDTIGVLG NKYPFSKIPL ASLTPKAQRE IFSAWISHRP 

       190        200        210        220        230        240 
VVLTGGTGVG KTSQVPKLLL WFNYLFGGFS TLDKITDFHE RPVILSLPRI ALVRLHSNTI 

       250        260        270        280        290        300 
LKSLGFKVLD GSPISLRYGS IPEELINKQP KKYGIVFSTH KLSLTKLFSY GTLIIDEVHE 

       310        320        330        340        350        360 
HDQIGDIIIA VARKHHTKID SMFLMTATLE DDRERLKVFL PNPAFIHIPG DTLFKISEVF 

       370        380        390        400        410        420 
IHNKINPSSR MAYIEEEKRN LVTAIQMYTP PDGSSGIVFV ASVAQCHEYK SYLEKRLPYD 

       430        440        450        460        470        480 
MYIIHGKVLE IDKILEKVYS SPNVSIIISA PYLESSVTIH NVTHIYDMGR VFVPAPFGGS 

       490        500        510        520        530        540 
QQFISKSMRD QRKGRVGRVN PGTYVYFYDL SYMKSIQRIN SEFLHNYILY ANKFNLTLPE 

       550        560        570        580        590        600 
DLFIIPTNLD ILWRTKEYID SFDISTETWN KLLSNYYMKM IEYAKLYVLS PILAEELDNF 

       610        620        630        640        650        660 
ERTGELTSIV QEAILSLNLR IKILNFKHKD NDTYIHFCKI LFGVYNGTNA TIYYHRPLTG 

       670 
YMNMISDTIF VPVDNN 

P33051 in FASTA format

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