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UniProtKB/Swiss-Prot entry P32789


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ALK2_YEAST
Primary accession number P32789
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on October 1, 1993 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 50)
Name and origin of the protein
Protein name Serine/threonine-protein kinase Haspin homolog ALK2
Synonym EC 2.7.11.1
Gene name
Name: ALK2
OrderedLocusNames: YBL009W
ORFNames: YBL0317
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=1441753 [NCBI, ExPASy, EBI, Israel, Japan]
Delaveau T., Jacq C., Perea J.;
"Sequence of a 12.7 kb segment of yeast chromosome II identifies a PDR-like gene and several new open reading frames.";
Yeast 8:761-768(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=7813418 [NCBI, ExPASy, EBI, Israel, Japan]
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.;
"Complete DNA sequence of yeast chromosome II.";
EMBO J. 13:5795-5809(1994).
[3]
FUNCTION, INDUCTION, PHOSPHORYLATION, DOMAINS, AND MUTAGENESIS OF 528-E--L-532.
PubMed=16855400 [NCBI, ExPASy, EBI, Israel, Japan]
Nespoli A., Vercillo R., di Nola L., Diani L., Giannattasio M., Plevani P., Muzi-Falconi M.;
"Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast.";
Cell Cycle 5:1464-1471(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z35770; CAA84828.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S47695; AAB23988.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S41217; S41217.
RefSeq NP_009544.1; -.
3D structure databases
ModBase P32789.
Protein-protein interaction databases
DIP DIP:5484N; -.
Organism-specific databases
CYGD YBL009w; -.
SGD S000000105; ALK2.
Yeast-GFP YBL009W.
Gene expression databases
ArrayExpress P32789; -.
GermOnline YBL009W; Saccharomyces cerevisiae.
Ontologies
GO
GO:0004672; Molecular function: protein kinase activity (inferred from direct assay from SGD).
GO:0007126; Biological process: meiosis (inferred from expression pattern from SGD).
GO:0007067; Biological process: mitosis (inferred from expression pattern from SGD).
GO:0006468; Biological process: protein amino acid phosphorylation (inferred from direct assay from SGD).
QuickGo view.
Family and domain databases
InterPro IPR000719; Prot_kinase_core.
Graphical view of domain structure.
PROSITE PS50011; PROTEIN_KINASE_DOM; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
BLOCKS P32789.
Genome annotation databases
Ensembl YBL009W; Saccharomyces cerevisiae. [Contig view]
GeneID 852274; -.
GenomeReviews Y13134_GR; YBL009W.
KEGG sce:YBL009W; -.
NMPDR fig|4932.3.peg.237; -.
Phylogenomic databases
HOGENOM P32789; -.
Other
LinkHub P32789; -.
ProtoNet P32789.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell cycle; Complete proteome; DNA damage; Kinase; Nucleotide-binding; Phosphoprotein; Serine/threonine-protein kinase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   676  676     Serine/threonine-protein kinase Haspin homolog ALK2. PRO_0000202464
DOMAIN   383   672  290     Protein kinase. 
NP_BIND   389   397  9     ATP (By similarity). 
MOTIF   116   118  3     KEN box. 
MOTIF   150   158  9     D box. 
COMPBIAS   29   309  281     Ser-rich. 
BINDING   430   430        ATP (By similarity). 
MUTAGEN   528   532        EHRNL->AAAAA: Reduces strongly kinase activity. 
Sequence information
Length: 676 AA [This is the length of the unprocessed precursor] Molecular weight: 76372 Da [This is the MW of the unprocessed precursor] CRC64: 0E7B84FC74142206 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNFDAVADQQ MTDRRYFALE VAESDDADSS LNSSSMGSPA VDVGRKVYKI TSHKGSAEDE 

        70         80         90        100        110        120 
SQSFFTSSDS PTSKTRPVGK TIENDDYYGK RSSTGSSLKQ LFNKININDT AHSSNKENVS 

       130        140        150        160        170        180 
QSVLSENKLL SPSKRLSKQG LTKVTNSKFR TPLRPISNQS TLSRDEPVKD FRSLKFRSGS 

       190        200        210        220        230        240 
DFKCWGDEKT SSHVHSSSVN SVNSFTSTTS SSKWKFWKND NLLSRSLSSR SVNDQDPNFV 

       250        260        270        280        290        300 
QPKPTNSLQK KSSISSFHNS IFGGGKHTEK KRNSGFIMPD HQSTKELNHK HSSSNLSFRS 

       310        320        330        340        350        360 
LKHKTSHSSL NKLKVRRKGN TQELNHPIKK TCQISLPVPD QVSKDKIQLK LKNSTSLASL 

       370        380        390        400        410        420 
SSEVTPINTL DYNDSILQQI LQLCDVKYIL HDLREAQSLG LFTLNTRSVQ LSHNFWQTYH 

       430        440        450        460        470        480 
SDMQTSLICK KVCLGALSDL TTSNLISLHE LKSLRLIQGT SGVANLLQAY VVPSNQCEND 

       490        500        510        520        530        540 
QNLILYLFFK YQGTPLSRCS NIDYSQALSI FWQCSSILYV AESKFQLEHR NLTLDHILID 

       550        560        570        580        590        600 
SKGNVTLIDM KCCRFLNIDN NKASYTRLDH HYFFQGRGTL QFEIYELMRS MLPQPISWAT 

       610        620        630        640        650        660 
FEPRTNLLWL YHLSSSLLKM AKKAVVSGAL NREENILIEL THLLDPARKH SKTIFKKELV 

       670 
IRTCGDLLSL KGEIMQ 

P32789 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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