ID MSS1_YEAST Reviewed; 526 AA. AC P32559; Q0PHA7; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 2. DT 10-JUN-2008, entry version 66. DE tRNA modification GTPase MSS1, mitochondrial precursor. GN Name=MSS1; Synonyms=PET53; OrderedLocusNames=YMR023C; GN ORFNames=YM9711.13C; OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; OC Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=93323132; PubMed=8392589; DOI=10.1006/jmbi.1993.1371; RA Decoster E., Vassal A., Faye G.; RT "MSS1, a nuclear-encoded mitochondrial GTPase involved in the RT expression of COX1 subunit of cytochrome c oxidase."; RL J. Mol. Biol. 232:79-88(1993). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Li X., Wang X., Guan M.-X.; RT "MSS1, a mitochondrial GTP-binding protein involved in mitochondrial RT tRNA modification."; RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204511 / S288c / AB972; RX MEDLINE=97313268; PubMed=9169872; RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., RA Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., RA Rice P., Skelton J., Walsh S.V., Whitehead S., Barrell B.G.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome RT XIII."; RL Nature 387:90-93(1997). RN [4] RP INTERACTION WITH MTO1. RX MEDLINE=98447639; PubMed=9774408; DOI=10.1074/jbc.273.43.27945; RA Colby G., Wu M., Tzagoloff A.; RT "MTO1 codes for a mitochondrial protein required for respiration in RT paromomycin-resistant mutants of Saccharomyces cerevisiae."; RL J. Biol. Chem. 273:27945-27952(1998). RN [5] RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. RX MEDLINE=22923954; PubMed=14562095; DOI=10.1038/nature02026; RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., RA Weissman J.S., O'Shea E.K.; RT "Global analysis of protein localization in budding yeast."; RL Nature 425:686-691(2003). RN [6] RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. RX MEDLINE=22923965; PubMed=14562106; DOI=10.1038/nature02046; RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., RA Dephoure N., O'Shea E.K., Weissman J.S.; RT "Global analysis of protein expression in yeast."; RL Nature 425:737-741(2003). RN [7] RP FUNCTION. RX PubMed=15509579; DOI=10.1074/jbc.M409306200; RA Umeda N., Suzuki T., Yukawa M., Ohya Y., Shindo H., Watanabe K., RA Suzuki T.; RT "Mitochondria-specific RNA-modifying enzymes responsible for the RT biosynthesis of the wobble base in mitochondrial tRNAs. Implications RT for the molecular pathogenesis of human mitochondrial diseases."; RL J. Biol. Chem. 280:1613-1624(2005). CC -!- FUNCTION: GTPase involved in the 5-carboxymethylaminomethyl CC modification (mnm(5)s(2)U34) of the wobble uridine base in CC mitochondrial tRNAs. Involved in the expression of cytochrome c CC oxidase subunit 1 (COX1). Works in association with the small CC subunit of mitoribosomes. CC -!- SUBUNIT: Forms an heterodimer with MTO1. CC -!- SUBCELLULAR LOCATION: Mitochondrion. CC -!- MISCELLANEOUS: Present with 768 molecules/cell in log phase SD CC medium. CC -!- SIMILARITY: Belongs to the era/trmE GTP-binding protein family. CC TrmE subfamily. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X69481; CAA49238.1; -; Genomic_DNA. DR EMBL; DQ834923; ABG77646.1; -; Genomic_DNA. DR EMBL; Z49211; CAA89126.1; -; Genomic_DNA. DR PIR; S54025; S54025. DR RefSeq; NP_013736.1; -. DR DIP; DIP:5882N; -. DR IntAct; P32559; -. DR Ensembl; YMR023C; Saccharomyces cerevisiae. DR GeneID; 855037; -. DR GenomeReviews; Z71257_GR; YMR023C. DR KEGG; sce:YMR023C; -. DR NMPDR; fig|4932.3.peg.4782; -. DR CYGD; YMR023c; -. DR SGD; S000004625; MSS1. DR HOGENOM; P32559; -. DR LinkHub; P32559; -. DR GermOnline; YMR023C; Saccharomyces cerevisiae. DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD. DR GO; GO:0006412; P:translation; IMP:SGD. DR GO; GO:0006400; P:tRNA modification; IMP:SGD. DR InterPro; IPR005289; GTP_bd. DR InterPro; IPR002917; MMR_HSR1_GTP_bd. DR InterPro; IPR001806; Ras_trnsfrmng. DR InterPro; IPR005225; Small_GTP_bd. DR InterPro; IPR004520; ThdF. DR Pfam; PF01926; MMR_HSR1; 1. DR PRINTS; PR00449; RASTRNSFRMNG. DR TIGRFAMs; TIGR00650; MG442; 1. DR TIGRFAMs; TIGR00450; mnmE_trmE_thdF; 1. DR TIGRFAMs; TIGR00231; small_GTP; 1. PE 1: Evidence at protein level; KW Complete proteome; GTP-binding; Mitochondrion; Nucleotide-binding; KW Transit peptide; tRNA processing. FT TRANSIT 1 19 Mitochondrion (Potential). FT CHAIN 20 526 tRNA modification GTPase MSS1. FT /FTId=PRO_0000035781. FT NP_BIND 281 288 GTP (Potential). FT NP_BIND 328 332 GTP (Potential). FT NP_BIND 394 397 GTP (Potential). FT CONFLICT 53 53 A -> R (in Ref. 1; CAA49238). SQ SEQUENCE 526 AA; 58352 MW; 8740A374CA1E637D CRC64; MNSASFLQSR LISRSFLVRR SLKRYSGLAK PYTFQQPTIY ALSTPANQTS AIAIIRISGT HAKYIYNRLV DSSTVPPIRK AILRNIYSPS SCSVKPHDQK ESKILLDTSL LLYFQAPYSF TGEDVLELHV HGGKAVVNSI LKAIGSLHDR SSGKDIRFAL PGDFSRRAFQ NGKFDLTQLE GIKDLIDSET ESQRRSALSS FNGDNKILFE NWRETIIENM AQLTAIIDFA DDNSQEIQNT DEIFHNVEKN IICLRDQIVT FMQKVEKSTI LQNGIKLVLL GAPNVGKSSL VNSLTNDDIS IVSDIPGTTR DSIDAMINVN GYKVIICDTA GIREKSSDKI EMLGIDRAKK KSVQSDLCLF IVDPTDLSKL LPEDILAHLS SKTFGNKRII IVVNKSDLVS DDEMTKVLNK LQTRLGSKYP ILSVSCKTKE GIESLISTLT SNFESLSQSS ADASPVIVSK RVSEILKNDV LYGLEEFFKS KDFHNDIVLA TENLRYASDG IAKITGQAIG IEEILDSVFS KFCIGK //