[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=8383238 [NCBI, ExPASy, EBI, Israel, Japan] Birkenbach M.P., Josefsen K., Yalamanchili R.R., Lenoir G.M., Kieff E.; "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors."; J. Virol. 67:2209-2220(1993).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. TISSUE=Placenta; DOI=10.1006/geno.1994.1553; PubMed=7851893 [NCBI, ExPASy, EBI, Israel, Japan] Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W.; "Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2."; Genomics 23:643-650(1994).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[5]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND MASS SPECTROMETRY. DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan] Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Anal. Sci. 24:161-166(2008).

Comments

FUNCTION: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
INDUCTION: By EBV.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].
WEB RESOURCE: Name=Wikipedia; Note=CC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CC_chemokine_receptors";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L08176; AAA58615.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L31584; AAA74230.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L31582; AAA74230.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L31583; AAA74230.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L31581; AAA74231.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY587876; AAT52232.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC035343; AAH35343.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00027687; -.

PIR

A45680; A45680.
B55735; B55735.

RefSeq

NP_001829.1; -.

UniGene

Hs.370036

3D structure databases

HSSP

P34996; 1DDD. [HSSP ENTRY / PDB]

ModBase

P32248.

Protein-protein interaction databases

DIP

DIP:5855N; -.

Protein family/group databases

GPCRDB

P32248; CCR7_HUMAN.

PTM databases

PhosphoSite

P32248; -.

Enzyme and pathway databases

Reactome

REACT_14797; Signaling by GPCR.

Organism-specific databases

GC17M035963; -.

HIX0027171; -.

HGNC:1608; CCR7.

CAB003796; -.

600242; gene. [NCBI / EBI]

PharmGKB

PA26172; -.

Gene expression databases

ArrayExpress

P32248; -.

Bgee

P32248; -.

CleanEx

HS_CCR7; -.
HS_EVI1; -.

GermOnline

ENSG00000126353; Homo sapiens.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0016493;	Molecular function: C-C chemokine receptor activity (inferred from electronic annotation from InterPro).
GO:0006935;	Biological process: chemotaxis (traceable author statement from ProtInc).
GO:0007204;	Biological process: elevation of cytosolic calcium ion concentration (traceable author statement from ProtInc).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0006954;	Biological process: inflammatory response (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR001718; CC_7_rcpt.
IPR000355; Chmkine_rcpt.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.

PANTHER

PTHR19264:SF209; CC_7_rcpt; 1.

Pfam

PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00657; CCCHEMOKINER.
PR00641; CHEMOKINER7.
PR00237; GPCRRHODOPSN.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

P32248; -.

Genome annotation databases

Ensembl

ENSG00000126353; Homo sapiens. [Contig view]

GeneID

1236; -.

KEGG

hsa:1236; -.

Phylogenomic databases

HOGENOM

P32248; -.

HOVERGEN

P32248; -.

OMA

P32248; GCLSQER.

Other

5049; -.

CCR7; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Signal; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 24`	`24`	`Potential.`
`CHAIN`	`25 378`	`354`	`C-C chemokine receptor type 7.`	`PRO_0000012735`
`TOPO_DOM`	`25 59`	`35`	`Extracellular (Potential).`
`TRANSMEM`	`60 86`	`27`	`1 (Potential).`
`TOPO_DOM`	`87 95`	`9`	`Cytoplasmic (Potential).`
`TRANSMEM`	`96 116`	`21`	`2 (Potential).`
`TOPO_DOM`	`117 130`	`14`	`Extracellular (Potential).`
`TRANSMEM`	`131 152`	`22`	`3 (Potential).`
`TOPO_DOM`	`153 170`	`18`	`Cytoplasmic (Potential).`
`TRANSMEM`	`171 191`	`21`	`4 (Potential).`
`TOPO_DOM`	`192 219`	`28`	`Extracellular (Potential).`
`TRANSMEM`	`220 247`	`28`	`5 (Potential).`
`TOPO_DOM`	`248 263`	`16`	`Cytoplasmic (Potential).`
`TRANSMEM`	`264 289`	`26`	`6 (Potential).`
`TOPO_DOM`	`290 313`	`24`	`Extracellular (Potential).`
`TRANSMEM`	`314 331`	`18`	`7 (Potential).`
`TOPO_DOM`	`332 378`	`47`	`Cytoplasmic (Potential).`
`MOD_RES`	`151 151`		`Phosphoserine.`
`CARBOHYD`	`36 36`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`129 210`		`By similarity.`
`VARIANT`	`7 7`	`1`	`M -> V (in dbSNP:rs45521932 [NCBI]).`	`VAR_049383`
`CONFLICT`	`182 183`		`IW -> SA (in Ref. 1; AAA58615).`
`CONFLICT`	`337 337`		`L -> I (in Ref. 1; AAA58615).`

Sequence information

Length: 378 AA [This is the length of the unprocessed precursor]

Molecular weight: 42874 Da [This is the MW of the unprocessed precursor]

CRC64: D4CB4213841A1BD4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF 

        70         80         90        100        110        120 
LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL AVADILFLLT LPFWAYSAAK 

       130        140        150        160        170        180 
SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV 

       190        200        210        220        230        240 
GIWILATVLS IPELLYSDLQ RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS 

       250        260        270        280        290        300 
FCYLVIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL 

       310        320        330        340        350        360 
SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE QLRQWSSCRH 

       370 
IRRSSMSVEA ETTTTFSP

P32248 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools