ID   3HIDH_RABIT             Reviewed;          35 AA.
AC   P32185;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-NOV-2008, entry version 47.
DE   RecName: Full=3-hydroxyisobutyrate dehydrogenase;
DE            Short=HIBADH;
DE            EC=1.1.1.31;
DE   Flags: Fragment;
GN   Name=HIBADH;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RX   MEDLINE=89174651; PubMed=2647728;
RA   Rougraff P.M., Zhang B., Kuntz M.J., Harris R.A., Crabb D.W.;
RT   "Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate
RT   dehydrogenase. Evidence for its evolutionary relationship to other
RT   pyridine nucleotide-dependent dehydrogenases.";
RL   J. Biol. Chem. 264:5899-5903(1989).
CC   -!- CATALYTIC ACTIVITY: 3-hydroxy-2-methylpropanoate + NAD(+) = 2-
CC       methyl-3-oxopropanoate + NADH.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyisobutyrate dehydrogenase
CC       family.
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DR   HOVERGEN; P32185; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxyla...; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
DR   GO; GO:0006573; P:valine metabolic process; IEA:InterPro.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DHase-rel_CS.
DR   InterPro; IPR015815; 3hydroxyacid_DHase/Rdtase.
DR   InterPro; IPR006115; 6PGDH_NAD-bd.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR22981; 3hydroxy_acid_DH; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase.
FT   CHAIN         1    >35       3-hydroxyisobutyrate dehydrogenase.
FT                                /FTId=PRO_0000173054.
FT   NP_BIND       4     33       NAD (By similarity).
FT   NON_TER      35     35
SQ   SEQUENCE   35 AA;  3796 MW;  C15D62589F84ED64 CRC64;
     ASKTPVGFIG LGNMGNPMAK NLMKHGYPLI IYDVF
//