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UniProtKB/Swiss-Prot entry P32121

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARRB2_HUMAN
Primary accession number P32121
Secondary accession numbers Q0Z8D3 Q2PP19 Q6ICT3 Q8N7Y2 Q9UEQ6
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on March 5, 2002 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 80)
Name and origin of the protein
Protein name Beta-arrestin-2
Synonym Arrestin beta-2
Gene name
Name: ARRB2
Synonyms: ARB2, ARR2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Thyroid;
DOI=10.1016/0303-7207(92)90038-8; PubMed=1587386 [NCBI, ExPASy, EBI, Israel, Japan]
Rapoport B., Kaufman K.D., Chamenbalk G.D.;
"Cloning of a member of the arrestin family from a human thyroid cDNA library.";
Mol. Cell. Endocrinol. 84:R39-R43(1992).
[2]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
Yu Q.M., Zhou T.H., Wu Y.L., Cheng Z.J., Ma L., Pei G.;
"G-protein coupled receptor interaction with beta-arrestin 2 through specific agonist stimulation.";
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Sanchez-Laorden B.L., Jimenez-Cervantes C., Garcia-Borron J.C.;
"A new splice-variant of beta-arrestin 2 is involved in agonist-induced MC1R endocytosis.";
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
[4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
TISSUE=Testis;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[6]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NHLBI resequencing and genotyping service (RS&G);
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
[7]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Muscle, and Pancreas;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z11501; CAA77577.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF106941; AAC99468.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ664180; ABG47460.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK097542; BAC05094.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR450310; CAG29306.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ314866; ABC40725.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007427; AAH07427.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067368; AAH67368.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S18984; S18984.
RefSeq NP_004304.1; -.
NP_945355.1; -.
UniGene Hs.435811
3D structure databases
HSSP P17870; 1G4M. [HSSP ENTRY / PDB]
ModBase P32121.
Protein-protein interaction databases
IntAct P32121; -.
PTM databases
PhosphoSite P32121; -.
Organism-specific databases
HGNC HGNC:712; ARRB2.
GenAtlas ARRB2.
MIM 107941; gene. [NCBI / EBI]
PharmGKB PA60; -.
GeneCards P32121.
Gene expression databases
ArrayExpress P32121; -.
CleanEx HS_ARRB2; -.
GermOnline ENSG00000141480; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (traceable author statement from ProtInc).
GO:0005886; Cellular component: plasma membrane (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR000698; Arrestin.
IPR011022; Arrestin-like_C.
IPR011021; Arrestin-like_N.
IPR014752; Arrestin_C.
IPR014753; Arrestin_N.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.640; Arrestin_C; 1.
G3DSA:2.60.40.840; Arrestin_N; 1.
PANTHER PTHR11792; Arrestin; 1.
Pfam PF02752; Arrestin_C; 1.
PF00339; Arrestin_N; 1.
Pfam graphical view of domain structure.
PRINTS PR00309; ARRESTIN.
ProDom PD002099; Arrestin; 2.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00295; ARRESTINS; 1.
BLOCKS P32121.
Genome annotation databases
Ensembl ENSG00000141480; Homo sapiens. [Contig view]
GeneID 409; -.
KEGG hsa:409; -.
Phylogenomic databases
HOVERGEN P32121; -.
Other
SOURCE ARRB2; Homo sapiens.
ProtoNet P32121.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cytoplasm; Nucleus; Phosphoprotein; Sensory transduction.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   409  409     Beta-arrestin-2. PRO_0000205199
MOTIF   389   399  11     Nuclear export signal (By similarity). 
MOD_RES   48    48        Phosphotyrosine (By similarity). 
VAR_SEQ   39    53        Missing (in isoform 3). VSP_008194
VAR_SEQ   360   360        S -> SAPTPTPPLPVPP (in isoform 2 and isoform 3). VSP_008195
CONFLICT   189   189        R -> P (in Ref. 1; CAA77577). 
CONFLICT   190   190        H -> R (in Ref. 3; ABG47460). 
CONFLICT   192   192        L -> P (in Ref. 5; CAG29306). 
Sequence information
Length: 409 AA [This is the length of the unprocessed precursor] Molecular weight: 46106 Da [This is the MW of the unprocessed precursor] CRC64: DEEC507D4A7B84FF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC 

        70         80         90        100        110        120 
AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI 

       130        140        150        160        170        180 
PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG 

       190        200        210        220        230        240 
PQPSAETTRH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA 

       250        260        270        280        290        300 
DICLFSTAQY KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN 

       310        320        330        340        350        360 
LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH DHIPLPRPQS 

       370        380        390        400 
AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK DDDYDDQLC
P32121 in FASTA format

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