[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1006/viro.1993.1128; PubMed=8382399 [NCBI, ExPASy, EBI, Israel, Japan] Pena L., Yanez R.J., Revilla Y., Vinuela E., Salas M.L.; "African swine fever virus guanylyltransferase."; Virology 193:319-328(1993).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1006/viro.1995.1149; PubMed=11831707 [NCBI, ExPASy, EBI, Israel, Japan] Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C., Rodriguez J.F., Vinuela E.; "Analysis of the complete nucleotide sequence of African swine fever virus."; Virology 208:249-278(1995).

Comments

FUNCTION: Catalyzes the second reaction in the mRNA cap formation pathway (Probable).
CATALYTIC ACTIVITY: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA.
PATHWAY: mRNA processing; mRNA capping .
SIMILARITY: Belongs to the viral GTase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L07263; AAA42692.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U18466; AAA65330.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A45391; A45391.

RefSeq

NP_042794.1; -.

3D structure databases

ModBase

P32094.

Ontologies

GO:0004484;	Molecular function: mRNA guanylyltransferase activity (inferred from electronic annotation from InterPro).
GO:0006370;	Biological process: mRNA capping (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR001339; mRNA_cap_enzyme.
Graphical view of domain structure.

Pfam

PF01331; mRNA_cap_enzyme; 1.
Pfam graphical view of domain structure.

Genome annotation databases

GeneID

1488865; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

GTP-binding; mRNA capping; mRNA processing; Nucleotide-binding; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 868`	`868`	`Probable mRNA-capping enzyme.`	`PRO_0000210132`
`ACT_SITE`	`282 282`		`N6-GMP-lysine intermediate (Potential).`

Sequence information

Length: 868 AA [This is the length of the unprocessed precursor]

Molecular weight: 99969 Da [This is the MW of the unprocessed precursor]

CRC64: 7068ED099D38ADA2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASLDNLVAR YQRCFNDQSL KNSTIELEIR FQQINFLLFK TVYEALVAQE IPSTISHSIR 

        70         80         90        100        110        120 
CIKKVHHENH CREKILPSEN LYFKKQPLMF FKFSEPASLG CKVSLAIEQP IRKFILDSSV 

       130        140        150        160        170        180 
LVRLKNRTTF RVSELWKIEL TIVKQLMGSE VSAKLAAFKT LLFDTPEQQT TKNMMTLINP 

       190        200        210        220        230        240 
DDEYLYEIEI EYTGKPESLT AADVIKIKNT VLTLISPNHL MLTAYHQAIE FIASHILSSE 

       250        260        270        280        290        300 
ILLARIKSGK WGLKRLLPQV KSMTKADYMK FYPPVGYYVT DKADGIRGIA VIQDTQIYVV 

       310        320        330        340        350        360 
ADQLYSLGTT GIEPLKPTIL DGEFMPEKKE FYGFDVIMYE GNLLTQQGFE TRIESLSKGI 

       370        380        390        400        410        420 
KVLQAFNIKA EMKPFISLTS ADPNVLLKNF ESIFKKKTRP YSIDGIILVE PGNSYLNTNT 

       430        440        450        460        470        480 
FKWKPTWDNT LDFLVRKCPE SLNVPEYAPK KGFSLHLLFV GISGELFKKL ALNWCPGYTK 

       490        500        510        520        530        540 
LFPVTQRNQN YFPVQFQPSD FPLAFLYYHP DTSSFSNIDG KVLEMRCLKR EINYVRWEIV 

       550        560        570        580        590        600 
KIREDRQQDL KTGGYFGNDF KTAELTWLNY MDPFSFEELA KGPSGMYFAG AKTGIYRAQT 

       610        620        630        640        650        660 
ALISFIKQEI IQKISHQSWV IDLGIGKGQD LGRYLDAGVR HLVGIDKDQT ALAELVYRKF 

       670        680        690        700        710        720 
SHATTRQHKH ATNIYVLHQD LAEPAKEISE KVHQIYGFPK EGASSIVSNL FIHYLMKNTQ 

       730        740        750        760        770        780 
QVENLAVLCH KLLQPGGMVW FTTMLGEQVL ELLHENRIEL NEVWEARENE VVKFAIKRLF 

       790        800        810        820        830        840 
KEDILQETGQ EIGVLLPFSN GDFYNEYLVN TAFLIKIFKH HGFSLVQKQS FKDWIPEFQN 

       850        860 
FSKSLYKILT EADKTWTSLF GFICLRKN

P32094 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools