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UniProtKB/Swiss-Prot entry P32019


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name I5P2_HUMAN
Primary accession number P32019
Secondary accession numbers Q5VSG9 Q5VSH0 Q5VSH1 Q658Q5 Q6P6D4 Q6PD53 Q86YE1
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on February 15, 2005 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 80)
Name and origin of the protein
Protein name Type II inositol-1,4,5-trisphosphate 5-phosphatase [Precursor]
Synonyms EC 3.1.3.36
Phosphoinositide 5-phosphatase
5PTase
75 kDa inositol polyphosphate-5-phosphatase
Gene name
Name: INPP5B
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
DOI=10.1074/jbc.270.16.9370; PubMed=7721860 [NCBI, ExPASy, EBI, Israel, Japan]
Jefferson A.B., Majerus P.W.;
"Properties of type II inositol polyphosphate 5-phosphatase.";
J. Biol. Chem. 270:9370-9377(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3), AND VARIANT MET-745.
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
TISSUE=Lymph;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-178.
TISSUE=Stomach;
The German cDNA consortium;
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 284-954, AND PROTEIN SEQUENCE OF 321-339.
TISSUE=Placenta;
PubMed=1718960 [NCBI, ExPASy, EBI, Israel, Japan]
Ross T.S., Jefferson A.B., Mitchell C.A., Majerus P.W.;
"Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase.";
J. Biol. Chem. 266:20283-20289(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M74161; AAA79207.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL603790; CAH69926.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL929472; CAH69926.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL603790; CAH69928.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL929472; CAH69928.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL603790; CAH69929.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL929472; CAH69929.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL929472; CAH70076.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL603790; CAH70076.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL929472; CAH70079.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL603790; CAH70079.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL929472; CAH70080.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL603790; CAH70080.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC042529; AAH42529.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC058932; AAH58932.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL833055; CAH56301.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_005531.2; -.
UniGene Hs.449942
3D structure databases
HSSP O43001; 1I9Z. [HSSP ENTRY / PDB]
ModBase P32019.
PTM databases
PhosphoSite P32019; -.
Enzyme and pathway databases
Reactome REACT_11044; Signaling by Rho GTPases.
Organism-specific databases
H-InvDB HIX0000445; -.
HGNC HGNC:6077; INPP5B.
GenAtlas INPP5B.
MIM 147264; gene. [NCBI / EBI]
PharmGKB PA29885; -.
GeneCards P32019.
Gene expression databases
ArrayExpress P32019; -.
CleanEx HS_INPP5B; -.
GermOnline ENSG00000204084; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (non-traceable author statement from UniProtKB).
GO:0004445; Molecular function: inositol-polyphosphate 5-phosphatase activity (non-traceable author statement from UniProtKB).
GO:0004439; Molecular function: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (inferred from electronic annotation from EC).
GO:0007165; Biological process: signal transduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR005135; Endo/exonuclease/phosphatase.
IPR000300; IPPc.
IPR000198; RhoGAP.
Graphical view of domain structure.
Gene3D G3DSA:1.10.555.10; RhoGAP; 1.
Pfam PF03372; Exo_endo_phos; 1.
PF00620; RhoGAP; 1.
Pfam graphical view of domain structure.
SMART SM00128; IPPc; 1.
SM00324; RhoGAP; 1.
SMART graphical view of domain structure.
PROSITE PS50238; RHOGAP; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P32019.
ProtoNet P32019.
Genome annotation databases
Ensembl ENSG00000204084; Homo sapiens. [Contig view]
GeneID 3633; -.
KEGG hsa:3633; -.
Phylogenomic databases
HOVERGEN P32019; -.
Other
NextBio 14219; -.
SOURCE INPP5B; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Direct protein sequencing; Hydrolase; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
PROPEP   1   320  320      PRO_0000015639
CHAIN   321   993  673     Type II inositol-1,4,5-trisphosphate 5-phosphatase. PRO_0000015640
DOMAIN   821   993  173     Rho-GAP. 
VAR_SEQ   1   244        Missing (in isoform 3). VSP_012821
VAR_SEQ   178   257        Missing (in isoform 2). VSP_012820
VAR_SEQ   810   828        TLMPVWTGDDGSQLDSPME -> LAYLAAYCFETQLVTKSLI (in isoform 4). VSP_013902
VAR_SEQ   829   993        Missing (in isoform 4). VSP_013903
VARIANT   745   745  1     T -> M (in dbSNP:rs11488569 [NCBI]). VAR_028002 
CONFLICT   587   606        GSDDWDTSEKCRAPAWCDRI -> RALTTGIPVRSAVLLPGVIGF (in Ref. 5; AA sequence). 
CONFLICT   911   911        G -> P (in Ref. 5; AA sequence). 
Sequence information
Length: 993 AA [This is the length of the unprocessed precursor] Molecular weight: 112822 Da [This is the MW of the unprocessed precursor] CRC64: ADEE581CC8FD29D6 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDQSVAIQET LAEGEYCVIA VQGVLCEGDS RQSRLLGLVR YRLEHGGQEH ALFLYTHRRM 

        70         80         90        100        110        120 
AITGDDVSLD QIVPVSRDFT LEEVSPDGEL YILGSDVTVQ LDTAELSLVF QLPFGSQTRM 

       130        140        150        160        170        180 
FLHEVARACP GFDSATRDPE FLWLSRYRCA ELELEMPTPR GCNSALVTWP GYATIGGGRY 

       190        200        210        220        230        240 
PSRKKRWGLE EARPQGAGSV LFWGGAMEKT GFRLMERAHG GGFVWGRSAR DGRRDEELEE 

       250        260        270        280        290        300 
AGREMSAAAG SRERNTAGGS NFDGLRPNGK GVPMDQSSRG QDKPESLQPR QNKSKSEITD 

       310        320        330        340        350        360 
MVRSSTITVS DKAHILSMQK FGLRDTIVKS HLLQKEEDYT YIQNFRFFAG TYNVNGQSPK 

       370        380        390        400        410        420 
ECLRLWLSNG IQAPDVYCVG FQELDLSKEA FFFHDTPKEE EWFKAVSEGL HPDAKYAKVK 

       430        440        450        460        470        480 
LIRLVGIMLL LYVKQEHAAY ISEVEAETVG TGIMGRMGNK GGVAIRFQFH NTSICVVNSH 

       490        500        510        520        530        540 
LAAHIEEYER RNQDYKDICS RMQFCQPDPS LPPLTISNHD VILWLGDLNY RIEELDVEKV 

       550        560        570        580        590        600 
KKLIEEKDFQ MLYAYDQLKI QVAAKTVFEG FTEGELTFQP TYKYDTGSDD WDTSEKCRAP 

       610        620        630        640        650        660 
AWCDRILWKG KNITQLSYQS HMALKTSDHK PVSSVFDIGV RVVNDELYRK TLEEIVRSLD 

       670        680        690        700        710        720 
KMENANIPSV SLSKREFCFQ NVKYMQLKVE SFTIHNGQVP CHFEFINKPD EESYCKQWLN 

       730        740        750        760        770        780 
ANPSRGFLLP DSDVEIDLEL FVNKTTATKL NSGEDKIEDI LVLHLDRGKD YFLSVSGNYL 

       790        800        810        820        830        840 
PSCFGSPIHT LCYMREPILD LPLETISELT LMPVWTGDDG SQLDSPMEIP KELWMMVDYL 

       850        860        870        880        890        900 
YRNAVQQEDL FQQPGLRSEF EHIRDCLDTG MIDNLSASNH SVAEALLLFL ESLPEPVICY 

       910        920        930        940        950        960 
STYHNCLECS GNYTASKQVI STLPIFHKNV FHYLMAFLRE LLKNSAKNHL DENILASIFG 

       970        980        990 
SLLLRNPAGH QKLDMTEKKK AQEFIHQFLC NPL 

P32019 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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