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UniProtKB/Swiss-Prot entry P31946

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 1433B_HUMAN
Primary accession number P31946
Secondary accession numbers None
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    April 29, 2008 (Entry version 95)
Name and origin of the protein
Protein name 14-3-3 protein beta/alpha
Synonyms Protein kinase C inhibitor protein 1
KCIP-1
Protein 1054
Gene name
Name: YWHAB
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Keratinocyte;
DOI=10.1006/jmbi.1993.1346; PubMed=8515476 [NCBI, ExPASy, EBI, Israel, Japan]
Leffers H., Madsen P., Rasmussen H.H., Honore B., Andersen A.H., Walbum E., Vandekerckhove J., Celis J.E.;
"Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.";
J. Mol. Biol. 231:982-998(1993).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
 PROTEIN SEQUENCE OF 3-20.
TISSUE=Platelet;
DOI=10.1038/nbt810; PubMed=12665801 [NCBI, ExPASy, EBI, Israel, Japan]
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.;
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.";
Nat. Biotechnol. 21:566-569(2003).
[5]
 INTERACTION WITH CRTC2.
DOI=10.1016/j.cell.2004.09.015; PubMed=15454081 [NCBI, ExPASy, EBI, Israel, Japan]
Screaton R.A., Conkright M.D., Katoh Y., Best J.L., Canettieri G., Jeffries S., Guzman E., Niessen S., Yates J.R. III, Takemori H., Okamoto M., Montminy M.;
"The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.";
Cell 119:61-74(2004).
[6]
 INTERACTION WITH SSH1.
DOI=10.1083/jcb.200401136; PubMed=15159416 [NCBI, ExPASy, EBI, Israel, Japan]
Nagata-Ohashi K., Ohta Y., Goto K., Chiba S., Mori R., Nishita M., Ohashi K., Kousaka K., Iwamatsu A., Niwa R., Uemura T., Mizuno K.;
"A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.";
J. Cell Biol. 165:465-471(2004).
[7]
 SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
DOI=10.1021/pr060363j; PubMed=17081065 [NCBI, ExPASy, EBI, Israel, Japan]
Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F.;
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.";
J. Proteome Res. 5:3135-3144(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X57346; CAA40621.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL008725; CAA15497.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001359; AAH01359.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S34755; S34755.
RefSeq NP_003395.1; -.
NP_647539.1; -.
UniGene Hs.651212
3D structure databases
PDB
2BQ0; X-ray; 2.50 A; A/B=1-239.[ExPASy / RCSB / EBI]
2C23; X-ray; 2.65 A; A=1-239.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2BQ0; -.
2C23; -.
ModBase P31946.
Protein-protein interaction databases
DIP DIP:743N; -.
IntAct P31946; -.
PTM databases
PhosphoSite P31946; -.
Enzyme and pathway databases
Reactome REACT_578; Apoptosis.
2D gel databases
Cornea-2DPAGE P31946; -.
OGP P31946; -.
REPRODUCTION-2DPAGE IPI00216318; -.
Organism-specific databases
H-InvDB HIX0015846; -.
HGNC HGNC:12849; YWHAB.
GeneLynx YWHAB; Homo sapiens.
GenAtlas YWHAB.
HPA CAB003759; -.
MIM 601289; gene. [NCBI / EBI]
PharmGKB PA37438; -.
GeneCards P31946.
Gene expression databases
ArrayExpress P31946; -.
CleanEx HS_YWHAB; -.
GermOnline ENSG00000166913; Homo sapiens.
Ontologies
GO
GO:0048471; Cellular component: perinuclear region of cytoplasm (inferred from direct assay from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR000308; 14-3-3.
Graphical view of domain structure.
Gene3D G3DSA:1.20.190.20; 14-3-3; 1.
PANTHER PTHR18860; 14-3-3; 1.
Pfam PF00244; 14-3-3; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000868; 14-3-3; 1.
PRINTS PR00305; 1433ZETA.
ProDom PD000600; 14-3-3; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00101; 14_3_3; 1.
SMART graphical view of domain structure.
PROSITE PS00796; 1433_1; 1.
PS00797; 1433_2; 1.
BLOCKS P31946.
Genome annotation databases
Ensembl ENSG00000166913; Homo sapiens. [Contig view]
GeneID 7529; -.
KEGG hsa:7529; -.
Other
SOURCE YWHAB; Homo sapiens.
ProtoNet P31946.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Acetylation; Alternative initiation; Cytoplasm; Direct protein sequencing; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   246  245     14-3-3 protein beta/alpha. PRO_0000000003
MOD_RES   2     2        N-acetylthreonine (By similarity). 
MOD_RES   186   186        Phosphoserine (By similarity). 
VAR_SEQ   1     2        Missing (in isoform Short). VSP_018632
HELIX   5    17  13      
HELIX   21    32  12      
HELIX   40    67  28      
HELIX   75   105  31      
HELIX   107   110  4      
HELIX   114   133  20      
HELIX   138   161  24      
HELIX   167   182  16      
HELIX   187   202  16      
HELIX   203   207  5      
TURN   210   212  3      
HELIX   213   231  19      
Sequence information
Length: 246 AA [This is the length of the unprocessed precursor] Molecular weight: 28082 Da [This is the MW of the unprocessed precursor] CRC64: 6BE1A9BF97468017 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS 

        70         80         90        100        110        120 
WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL ELLDKYLIPN ATQPESKVFY 

       130        140        150        160        170        180 
LKMKGDYFRY LSEVASGDNK QTTVSNSQQA YQEAFEISKK EMQPTHPIRL GLALNFSVFY 

       190        200        210        220        230        240 
YEILNSPEKA CSLAKTAFDE AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD 


AGEGEN
P31946 in FASTA format

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